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Gene Expression Data
Assay Details
Assay
Reference: J:171508 Ikegami D, et al., Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7287526
Gene symbol: Pten
Gene name: phosphatase and tensin homolog
Antibody: Anti-Pten (138G6; #9559L)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5D Sox9flox/+; Ptenflox/+: embryonic day 14.5; Ptentm2Mak/Pten+, Sox9tm2Crm/Sox9+ (more )
Note: Metaphyseal region of the humerus.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted 5D Anti-Pten Sox9flox/+;Ptenflox/+ Expression was detected in proliferative chondrocytes.
Specimen 5D 11Prom-Cre; Sox9flox/flox; Pten+/+: embryonic day 14.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant. Metaphyseal region of the humerus.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted 5D Anti-Pten 11Prom-Cre;Sox9flox/flox;Pten+/+ Expression was detected in proliferative chondrocytes.
Specimen 5D 11Prom-Cre; Sox9flox/flox; Ptenflox/flox: embryonic day 14.5; Ptentm2Mak/Ptentm2Mak, Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant. Metaphyseal region of the humerus.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Weak Regionally restricted 5D Anti-Pten 11Prom-Cre;Sox9flox/flox;Ptenflox/flox Expression was decreased in proliferative chondrocytes of the 11Prom-Cre; Sox9<flox/flox>; Pten<flox/flox> conditional mutant.
Specimen S6 Sox9flox/+; Ptenflox/+: embryonic day 14.5; Ptentm2Mak/Pten+, Sox9tm2Crm/Sox9+ (more )
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted S6_Anti-Pten Sox9flox/+;Ptenflox/+ Expression was detected in proliferative chondrocytes.
Specimen S6 11Prom-Cre; Sox9flox/flox; Pten+/+: embryonic day 14.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted S6_Anti-Pten 11Prom-Cre;Sox9flox/flox;Pten+/+ Expression was detected in proliferative chondrocytes.
Specimen S6 11Prom-Cre; Sox9flox/flox; Ptenflox/flox: embryonic day 14.5; Ptentm2Mak/Ptentm2Mak, Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Weak Regionally restricted S6_Anti-Pten 11Prom-Cre;Sox9flox/flox;Ptenflox/flox Expression was reduced in the Sox9-deleted proliferative chondrocytes in the 11Prom-Cre; Sox9<flox/flox>; Pten<flox/flox> conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/09/2024
MGI 6.24 		The Jackson Laboratory