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Gene Expression Data
Assay Details
Assay
Reference: J:331142 Han P, et al., Cbln1 regulates axon growth and guidance in multiple neural regions. PLoS Biol. 2022 Nov;20(11):e3001853
Assay type: RNA in situ
MGI Accession ID: MGI:7388445
Gene symbol: Cbln1
Gene name: cerebellin 1 precursor protein
Probe: Cbln1 probe4
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A E10.5: embryonic day 10.5 (more )
Structure Cell Type Level Pattern Image Note
TS17: neural tube floor plate Strong 1A E10.5 Strong expression in floor plate at E10.5.
TS17: future spinal cord commissural neuron Weak Regionally restricted 1A E10.5 Weak expression in dorsal commissural neurons.
Specimen 1A E11.5: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS19: neural tube floor plate Strong 1A E11.5 High level of expression maintained in floor plate.
TS19: future spinal cord commissural neuron Present Regionally restricted 1A E11.5 Expression increases in dorsal commissural neurons.
TS19: future spinal cord motor neuron Present Regionally restricted 1A E11.5 Expression appears in subpopulation of motor neurons.
Specimen 1A E12.5: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: spinal cord floor plate Strong 1A E12.5 High level of expression maintained in floor plate.
TS20: spinal cord commissural neuron Present Regionally restricted 1A E12.5 Expression increased in dorsal commissural neurons.
TS20: spinal cord motor neuron Present Regionally restricted 1A E12.5 Expression in subpopulation of motor neurons.
Specimen 2B Cbln1fl/fl: embryonic day 11.5; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj (more )
Structure Cell Type Level Pattern Image Note
TS19: future spinal cord commissural neuron Present Regionally restricted 2B Cbln1fl/fl Expression in dorsal commissural neurons.
Specimen 2B Wnt1-Cre: embryonic day 11.5; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: future spinal cord commissural neuron Absent 2B Wnt-Cre No expression in dorsal commissural neurons.
TS19: future spinal cord Present Regionally restricted 2B Wnt-Cre Expression in other parts of spinal cord was not affected.
Specimen 6A P4: postnatal day 4 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum internal granule cell layer cerebellar granule cell Strong Regionally restricted 6A P4 High and specific expression in granule cells, especially in internal granule layer.
Specimen 6A P8: postnatal day 8 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum internal granule cell layer cerebellar granule cell Strong Regionally restricted 6A P8 High and specific expression in granule cells, especially in internal granule layer.
Specimen 6C Cbln2fl/fl: postnatal day 8; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum internal granule cell layer cerebellar granule cell Strong Regionally restricted 6C Cbln1fl/fl High and specific expression in granule cells, especially in internal granule layer.
Specimen 6C Wnt1-Cre: postnatal day 8; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebellum internal granule cell layer Absent 6C Wnt-Cre Expression ablated in internal granule layer.
Specimen 7A: embryonic day 13.0 (more )
Structure Cell Type Level Pattern Image Note
TS21: retina retinal ganglion cell Absent 7A No expression in retinal ganglion cells.
Specimen 7B1: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: diencephalon floor plate Present Regionally restricted 7B1 Expression in floor of 3rd ventricle, adjacent to optic chiasm.
Specimen 7B2: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: diencephalon floor plate Present Regionally restricted 7B2 Expression in floor of 3rd ventricle, adjacent to optic chiasm.
Specimen 7F Cbln1fl/fl: embryonic day 13.0; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj (more )
Structure Level Pattern Image Note
TS21: diencephalon floor plate Present Regionally restricted 7F Cblnfl/fl Expression in floor of 3rd ventricle, adjacent to optic chiasm.
Specimen 7F Nes-Cre: embryonic day 13.0; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: diencephalon floor plate Absent 7F Nes-Cre Expression ablated in floor of 3rd ventricle.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory