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Gene Expression Data
Assay Details
Assay
Reference: J:331142 Han P, et al., Cbln1 regulates axon growth and guidance in multiple neural regions. PLoS Biol. 2022 Nov;20(11):e3001853
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7388462
Gene symbol: Robo3
Gene name: roundabout guidance receptor 3
Antibody: anti-Robo3
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2C Cbln1fl/fl: embryonic day 10.5; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj (more )
Structure Cell Type Level Pattern Image Note
TS17: future spinal cord commissural neuron Present Regionally restricted 2C' , 2C Cbln1fl/fl Expression in commissural axons.
Specimen 2C Wnt1-Cre: embryonic day 10.5; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS17: future spinal cord commissural neuron Present Regionally restricted 2C Wnt-Cre , 2C'' Lengths of commissural axons were shorter and numbers were fewer compared with controls.
Specimen S2I Cbln1fl/fl: embryonic day 12.0; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj (more )
Structure Cell Type Level Pattern Image Note
TS20: spinal cord commissural neuron Present Regionally restricted S2I Cbln1fl/fl Expression in commissural axons.
Specimen S2I Wnt1-Cre: embryonic day 12.0; Cbln1tm1.1Sjj/Cbln1tm1.1Sjj, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord commissural neuron Present Regionally restricted S2I Wnt1-Cre Almost all commissural axons reached floor plate. No difference in axon length or number compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory