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Gene Expression Data
Assay Details
Assay
Reference: J:324720 Zhao Q, et al., Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. J Cell Sci. 2022 Feb 15;135(4):jcs258956
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7467166
Gene symbol: Dnm1l
Gene name: dynamin 1-like
Results
Specimen S1 ctrl DRP1: embryonic day 9.5; Dnm1ltm1.1Hise/? (more )
Note: Double labeled: red - Drp1 (Dnm1l); green - MLC2A (Myl7 assay MGI:7467167).
Structure Level Pattern Image Note
TS15: common atrial chamber Present S1_ctrl merge , S1_ctrl DRP1
TS15: outflow tract Present S1_ctrl merge , S1_ctrl DRP1
TS15: primitive ventricle Present S1_ctrl merge , S1_ctrl DRP1
Specimen S1 mut DRP1: embryonic day 9.5; Dnm1ltm1.1Hise/Dnm1ltm1.1Hise, Tg(Mef2c-cre)2Blk/0 (more )
Note: Conditional mutant. Double labeled: red - Drp1 (Dnm1l); green - MLC2A (Myl7 assay MGI:7467167).
Structure Cell Type Level Pattern Image Note
TS15: outflow tract Weak S1_mut DRP1 , S1_mut merge Reduced expression in outflow tract.
TS15: primitive ventricle cardiac muscle cell Present Regionally restricted S1_mut DRP1 , S1_mut merge Reduced expression in half of right ventricle adjacent to outflow tract. Strong expression in other half of right ventricle. Expression in ~50% of cardiomyocytes.
TS15: common atrial chamber Present S1_mut DRP1 , S1_mut merge Expression in common atria unchanged compared to control.
Specimen 1A Ctrl (left) DRP1: embryonic day 10.5; Dnm1ltm1.1Hise/? (more )
Note: Double labeled: red - Drp1 (Dnm1l); green - MLC2A (Myl7 assay MGI:7467167).
Structure Level Pattern Image Note
TS17: outflow tract Present 1A Ctrl (left) DRP1 , 1A Ctrl (left) merge
Specimen 1A Mut (left) DRP1: embryonic day 10.5; Dnm1ltm1.1Hise/Dnm1ltm1.1Hise, Tg(Mef2c-cre)2Blk/0 (more )
Note: Conditional mutant. Double labeled: red - Drp1 (Dnm1l); green - MLC2A (Myl7 assay MGI:7467167).
Structure Cell Type Level Pattern Image Note
TS17: outflow tract cardiac muscle cell Trace 1A Mut (left) merge , 1A Mut (left) DRP1 Expression efficiently inactivated in outflow tract. Expression in very few cardiomyocytes.
Specimen 1A Ctrl (right) DRP1: embryonic day 10.5; Dnm1ltm1.1Hise/? (more )
Note: Double labeled: red - Drp1 (Dnm1l); green - MLC2A (Myl7 assay MGI:7467167).
Structure Level Pattern Image Note
TS17: atrioventricular canal Present 1A Ctrl (right) merge , 1A Ctrl (right) DRP1
TS17: common atrial chamber Present 1A Ctrl (right) merge , 1A Ctrl (right) DRP1
TS17: primitive ventricle Present 1A Ctrl (right) merge , 1A Ctrl (right) DRP1
Specimen 1A Mut (right) DRP1: embryonic day 10.5; Dnm1ltm1.1Hise/Dnm1ltm1.1Hise, Tg(Mef2c-cre)2Blk/0 (more )
Note: Conditional mutant. Double labeled: red - Drp1 (Dnm1l); green - MLC2A (Myl7 assay MGI:7467167).
Structure Cell Type Level Pattern Image Note
TS17: primitive ventricle cardiac muscle cell Present Regionally restricted 1A Mut (right) merge , 1A Mut (right) DRP1 Expression efficiently inactivated in right ventricle but not in other areas. Expression in very few cardiomyocytes in right ventricle
TS17: atrioventricular canal Present 1A Mut (right) merge , 1A Mut (right) DRP1 Expression in common atria and atioventricular canal regions unchanged compared to control.
TS17: common atrial chamber Present 1A Mut (right) merge , 1A Mut (right) DRP1 Expression in common atria and atioventricular canal regions unchanged compared to control.
Specimen 4B Ctrl DRP1: embryonic day 10.5; Dnm1ltm1.1Hise/? (more )
Note: Double labeled: red - Drp1 (Dnm1l); green - TOM20 (Tomm20 assay MGI:7467170).
Structure Level Pattern Image Note
TS17: primitive ventricle Present 4B Ctr
Specimen 4B Mut DRP1: embryonic day 10.5; Dnm1ltm1.1Hise/? (more )
Note: Double labeled: red - Drp1 (Dnm1l); green - TOM20 (Tomm20 assay MGI:7467170).
Structure Level Pattern Image Note
TS17: primitive ventricle Present 4B Mut
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
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