Krt6 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:238698 Kasparek P, et al., KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype. PLoS Genet. 2017 Jan;13(1):e1006566
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7484321
Gene symbol:	Krt6
Gene name:	keratin 6

Antibody:	anti-Keratin6
Detection system:	Secondary antibody

Results

5B Krt6 wt ©

Specimen 5B Krt6 wt: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: epidermis	Present		5B Krt6 wt

Specimen 5B Krt6 A135X/A135X: embryonic day 18.5; Spink5^em1Rase/Spink5^em1Rase (more

)

Structure	Level	Pattern	Image	Note
TS26: epidermis	Strong		5B Krt6 A135X/A135X	Expression increased compared to wild type.

Specimen 5B Krt6 Klk5-/-;A135X/A135X: embryonic day 18.5; Klk5^tm1Rase/Klk5^tm1Rase, Spink5^em1Rase/Spink5^em1Rase (more

)

Structure	Level	Pattern	Image	Note
TS26: epidermis	Present		5B Krt6 Klk5-/-;A135X/A135X	Expression not altered compared to wild type

Specimen 5B Krt6 Klk7-/-;A135X/A135X: embryonic day 18.5; Klk7^em1Rase/Klk7^em1Rase, Spink5^em1Rase/Spink5^em1Rase (more

)

Structure	Level	Pattern	Image	Note
TS26: epidermis	Present		5B Krt6 Klk7-/-;A135X/A135X	Expression not altered compared to wild type

Specimen 5B Krt6 Klk5-/-;Klk7-/-;A135X/A135X: embryonic day 18.5; Klk5^tm1Rase/Klk5^tm1Rase, Klk7^em1Rase/Klk7^em1Rase, Spink5^em1Rase/Spink5^em1Rase (more

)

Structure	Level	Pattern	Image	Note
TS26: epidermis	Present	Regionally restricted	5B Krt6 Klk5-/-;Klk7-/-;A135X/A135X	Expression not altered compared to wild type

6B wt ©

Specimen 6B wt: postnatal day 5 (more

)

Structure	Level	Pattern	Image	Note
TS28: epidermis	Present		6B wt

Specimen 6B Klk5-/-;A135X/A135X: postnatal day 5; Klk5^tm1Rase/Klk5^tm1Rase, Spink5^em1Rase/Spink5^em1Rase (more

)

Structure	Level	Pattern	Image	Note
TS28: epidermis	Strong		6B Klk5-/-;A135X/A135X	Expression increased compared to wild type.

Specimen 6B Klk5-/-;Klk7-/-;A135X/A135X: postnatal day 5; Klk5^tm1Rase/Klk5^tm1Rase, Klk7^em1Rase/Klk7^em1Rase, Spink5^em1Rase/Spink5^em1Rase (more

)

Structure	Level	Pattern	Image	Note
TS28: epidermis	Present		6B Klk5-/-;Klk7-/-;A135X/A135X	Authors report rescue.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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