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Gene Expression Data
Assay Details
Assay
Reference: J:183829 Correa SM, et al., Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7524449
Gene symbol: Foxl2
Gene name: forkhead box L2
Antibody: Anti-Foxl2 (C terminus)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1A Wt1+/+ XX: embryonic day 13.5 (more )
Note: Double labeled: green - Foxl2; red - Amh (assay MGI:7524455).
Structure Cell Type Level Pattern Image Note
TS21: mesenchymal stroma of ovary granulosa cell Present 1A
Specimen 1B Wt1+/+ XY AKR: embryonic day 13.5 (more )
Note: Double labeled: green - Foxl2; red - Amh (assay MGI:7524455).
Structure Level Pattern Image Note
TS21: gonad Present Single cells 1B Expressed in isolated cells within regions containing testicular cords.
Specimen 1C Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Gonads differentiated as ovotestes. Double labeled: green - Foxl2; red - Amh (assay MGI:7524455).
Structure Cell Type Level Pattern Image Note
TS21: gonad granulosa cell Present Regionally restricted 1C Expressed at the poles.
Specimen 1D Sf1+/+ XX: embryonic day 13.5 (more )
Note: Double labeled: green - Foxl2; red - Amh (assay MGI:7524455).
Structure Cell Type Level Pattern Image Note
TS21: mesenchymal stroma of ovary granulosa cell Present 1D
Specimen 1E Sf1+/+ XY AKR: embryonic day 13.5 (more )
Note: Double labeled: green - Foxl2; red - Amh (assay MGI:7524455).
Structure Level Pattern Image Note
TS21: gonad Present Scattered 1E Expressed in isolated cells within regions containing testicular cords.
Specimen 1F Sf1+/- XY AKR: embryonic day 13.5; Nr5a1tm1Klp/Nr5a1+ (more )
Note: Gonads differentiated as ovaries. Double labeled: green - Foxl2; red - Amh (assay MGI:7524455).
Structure Level Pattern Image Note
TS21: gonad Strong 1F Developed as ovaries, in a pattern similar to XX ovaries.
Specimen S2A left: embryonic day 13.5; X/SryAKR/JSryRIII (more )
Note: Triple labeled: green - Foxl2; red - Amh (assay MGI:7524455); blue - Pecam1 (assay MGI:7525435).
Structure Level Pattern Image Note
TS21: gonad Present Regionally restricted S2A left Expressed in the poles.
Specimen S2A right: embryonic day 13.5; X/SryAKR/JSryRIII (more )
Note: Triple labeled: green - Foxl2; red - Amh (assay MGI:7524455); blue - Pecam1 (assay MGI:7525435).
Structure Level Pattern Image Note
TS21: gonad Present Single cells S2A right Expressed in isolated cells within regions containing testicular cords.
Specimen not shown Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Gonads differentiated as ovaries.
Structure Level Pattern Image Note
TS21: gonad Strong Developed as ovaries, in a pattern similar to XX ovaries.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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