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Gene Expression Data
Assay Details
Assay
Reference: J:183829 Correa SM, et al., Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7524455
Gene symbol: Amh
Gene name: anti-Mullerian hormone
Antibody: anti-AMH
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 1A Wt1+/+ XX: embryonic day 13.5 (more )
Note: Double labeled: red - Amh; green - Foxl2 (assay MGI:7524449).
Structure Level Pattern Image Note
TS21: ovary Absent 1A
Specimen 1B Wt1+/+ XY AKR: embryonic day 13.5 (more )
Note: Double labeled: red - Amh; green - Foxl2 (assay MGI:7524449).
Structure Cell Type Level Pattern Image Note
TS21: Sertoli cell Sertoli cell Present 1B
Specimen 1C Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Gonads differentiated as ovotestes. Double labeled: red - Amh; green - Foxl2 (assay MGI:7524449).
Structure Level Pattern Image Note
TS21: gonad Present Regionally restricted 1C Expressed in the central region containing testicular cords but not at poles that lacked cords.
Specimen 1D Sf1+/+ XX: embryonic day 13.5 (more )
Note: Double labeled: red - Amh; green - Foxl2 (assay MGI:7524449).
Structure Level Pattern Image Note
TS21: ovary Absent 1D
Specimen 1E Sf1+/+ XY AKR: embryonic day 13.5 (more )
Note: Double labeled: red - Amh; green - Foxl2 (assay MGI:7524449).
Structure Cell Type Level Pattern Image Note
TS21: Sertoli cell Sertoli cell Strong 1E
Specimen 1F Sf1+/- XY AKR: embryonic day 13.5; Nr5a1tm1Klp/Nr5a1+ (more )
Note: Gonads differentiated as ovaries. Double labeled: red - Amh; green - Foxl2 (assay MGI:7524449).
Structure Level Pattern Image Note
TS21: gonad Absent 1F Developed as ovaries, similar to XX ovaries.
Specimen S2A left: embryonic day 13.5; X/SryAKR/JSryRIII (more )
Note: Triple labeled: red - Amh; green - Foxl2 (assay MGI:7524449); blue - Pecam1 (assay MGI:7525435).
Structure Cell Type Level Pattern Image Note
TS21: Sertoli cell Sertoli cell Present S2A left
Specimen S2A right: embryonic day 13.5; X/SryAKR/JSryRIII (more )
Note: Triple labeled: red - Amh; green - Foxl2 (assay MGI:7524449); blue - Pecam1 (assay MGI:7525435).
Structure Cell Type Level Pattern Image Note
TS21: Sertoli cell Sertoli cell Present S2A right
Specimen not shown Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Gonads differentiated as ovaries.
Structure Level Pattern Image Note
TS21: gonad Absent Developed as ovaries, similar to XX ovaries.
Specimen not shown Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Morphologically ovarian but expressed testicular markers (20%).
Structure Level Pattern Image Note
TS21: gonad Present Ovarian morphologically but contained positive cells.
Specimen not shown Sf1+/- XY AKR: embryonic day 13.5; Nr5a1tm1Klp/Nr5a1+ (more )
Note: Morphologically ovarian but expressed testicular markers (20%).
Structure Level Pattern Image Note
TS21: gonad Present Ovarian morphologically but contained positive cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory