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Gene Expression Data
Assay Details
Assay
Reference: J:183829 Correa SM, et al., Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7524456
Gene symbol: Fgfr2
Gene name: fibroblast growth factor receptor 2
Antibody: anti-FGFR2
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1G Wt1+/+ XX: embryonic day 13.5 (more )
Note: Double labeled: green - Fgfr2; red - Pdgfra (assay MGI:7524457).
Structure Level Pattern Image Note
TS21: ovary Present 1G Expressed on the surface of somatic cells.
Specimen 1H Wt1+/+ XY AKR: embryonic day 13.5 (more )
Note: Double labeled: green - Fgfr2; red - Pdgfra (assay MGI:7524457).
Structure Cell Type Level Pattern Image Note
TS21: Sertoli cell Sertoli cell Present 1H
Specimen 1I Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Morphologically ovarian but expressed testicular markers (20%). Double labeled: green - Fgfr2; red - Pdgfra (assay MGI:7524457).
Structure Level Pattern Image Note
TS21: gonad Present 1I Ovarian morphologically but contained many cells with positive nuclear localization (not organized into testicular cords).
Specimen 1J Sf1+/+ XX: embryonic day 13.5 (more )
Note: Double labeled: green - Fgfr2; red - Pdgfra (assay MGI:7524457).
Structure Level Pattern Image Note
TS21: ovary Present 1J Expressed on the surface of somatic cells.
Specimen 1K Sf1+/+ XY AKR: embryonic day 13.5 (more )
Note: Double labeled: green - Fgfr2; red - Pdgfra (assay MGI:7524457).
Structure Cell Type Level Pattern Image Note
TS21: Sertoli cell Sertoli cell Present 1K
Specimen 1L Sf1+/- XY AKR: embryonic day 13.5; Nr5a1tm1Klp/Nr5a1+ (more )
Note: Gonads differentiated as ovaries. Double labeled: green - Fgfr2; red - Pdgfra (assay MGI:7524457).
Structure Level Pattern Image Note
TS21: gonad Present 1L Expressed on the surface of somatic cells (ovarian pattern) but did not have cells with nuclear localization (testicular pattern).
Specimen not shown Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Gonads differentiated as ovaries.
Structure Level Pattern Image Note
TS21: gonad Present Expressed on the surface of somatic cells (ovarian pattern) but did not have cells with nuclear localization (testicular pattern).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory