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Gene Expression Data
Assay Details
Assay
Reference: J:183829 Correa SM, et al., Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7524457
Gene symbol: Pdgfra
Gene name: platelet derived growth factor receptor, alpha polypeptide
Antibody: anti-PDGFRa
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 1G Wt1+/+ XX: embryonic day 13.5 (more )
Note: Double labeled: red - Pdgfra; green - Fgfr2 (assay MGI:7524456).
Structure Level Pattern Image Note
TS21: mesenchymal stroma of ovary Present 1G Expressed at lower levels in interstitial cells.
Specimen 1H Wt1+/+ XY AKR: embryonic day 13.5 (more )
Note: Double labeled: red - Pdgfra; green - Fgfr2 (assay MGI:7524456).
Structure Level Pattern Image Note
TS21: coelomic epithelium of testis Strong 1H
TS21: interstitium of the testis Present 1H Expressed at lower levels in interstitial cells.
Specimen 1I Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Morphologically ovarian but expressed testicular markers (20%). Double labeled: red - Pdgfra; green - Fgfr2 (assay MGI:7524456).
Structure Level Pattern Image Note
TS21: gonad Present 1I Expressed in a testis-like pattern in the masculinized ovary.
Specimen 1J Sf1+/+ XX: embryonic day 13.5 (more )
Note: Double labeled: red - Pdgfra; green - Fgfr2 (assay MGI:7524456).
Structure Level Pattern Image Note
TS21: mesenchymal stroma of ovary Present 1J Expressed at lower levels in interstitial cells.
Specimen 1K Sf1+/+ XY AKR: embryonic day 13.5 (more )
Note: Double labeled: red - Pdgfra; green - Fgfr2 (assay MGI:7524456).
Structure Level Pattern Image Note
TS21: coelomic epithelium of testis Strong 1K
TS21: interstitium of the testis Present 1K Expressed at lower levels in interstitial cells.
Specimen 1L Sf1+/- XY AKR: embryonic day 13.5; Nr5a1tm1Klp/Nr5a1+ (more )
Note: Gonads differentiated as ovaries. Double labeled: red - Pdgfra; green - Fgfr2 (assay MGI:7524456).
Structure Level Pattern Image Note
TS21: gonad Present 1L Expressed in a pattern similar to XX ovaries.
Specimen not shown Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Gonads differentiated as ovotestes.
Structure Level Pattern Image Note
TS21: gonad Strong Regionally restricted Expressed at high levels in the coelomic epithelium of regions containing cords and at lower levels in regions without cords.
Specimen not shown Sf1+/- XY AKR: embryonic day 13.5; Nr5a1tm1Klp/Nr5a1+ (more )
Note: Gonads differentiated as ovotestes.
Structure Level Pattern Image Note
TS21: gonad Strong Regionally restricted Expressed at high levels in the coelomic epithelium of regions containing cords and at lower levels in regions without cords.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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