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Gene Expression Data
Assay Details
Assay
Reference: J:183829 Correa SM, et al., Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7524459
Gene symbol: Nr5a1
Gene name: nuclear receptor subfamily 5, group A, member 1
Antibody: Anti-Ad4bp/SF-1
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1M Wt1+/+ XX: embryonic day 13.5 (more )
Note: Double labeled: green - Nr5a1; red - Pecam1 (assay MGI:7524458).
Structure Level Pattern Image Note
TS21: ovary Present Uniform 1M Expressed at fairly equal levels in all somatic cells.
Specimen 1N Wt1+/+ XY AKR: embryonic day 13.5 (more )
Note: Double labeled: green - Nr5a1; red - Pecam1 (assay MGI:7524458).
Structure Cell Type Level Pattern Image Note
TS21: interstitium of the testis Present 1N Expression was up-regulated in Sertoli cells within testis cords and in specific interstitial cells, while down-regulated in most other interstitial cells.
TS21: Sertoli cell Sertoli cell Present 1N Expression was up-regulated in Sertoli cells within testis cords and in specific interstitial cells, while down-regulated in most other interstitial cells.
Specimen 1O Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Gonads differentiated as ovaries. Double labeled: green - Nr5a1; red - Pecam1 (assay MGI:7524458).
Structure Level Pattern Image Note
TS21: gonad Present Uniform 1O Expression was uniform in all somatic cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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