About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7529723
Gene symbol: Calca
Gene name: calcitonin/calcitonin-related polypeptide, alpha
Antibody: anti-CGRP
Results
Specimen 2C CGRP Control: postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted 2C CGRP Control Expression in cutaneous innervation of mystacial pads.
Specimen 2C CGRP cKO-Nes: postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Weak Regionally restricted 2C CGRP cKO-Nes Number of terminal axonal branches reduced compared to control.
Specimen 3A CGRP Control: postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: spinal cord Present Regionally restricted 3A CGRP Control Expression in small-caliber nociceptive axons entering dorsal spinal lamina.
Specimen 3A CGRP cKO-Nes: postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: spinal cord Present Regionally restricted 3A CGRP cKO-Nes Axons entered dorsal spinal lamina in a normal pattern.
Specimen 3E CGRP Control: postnatal day 1; Smad1tm1Abr/Smad1+ (more )
Structure Cell Type Level Pattern Image Note
TS27: thoracic dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 3E CGRP Control Expression in differentiated sensory neurons.
Specimen 3E CGRP cKO-Nes: postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: spinal cord sensory neuron of dorsal root ganglion Present Regionally restricted 3E CGRP cKO-Nes No change in central branch innervation compared to control.
Specimen S3E CGRP Control: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: spinal nerve dorsal root sensory neuron of spinal nerve Present Regionally restricted S3E CGRP Control Expression in cental axon projections of dorsal root ganglion sensory neurons into spinal cord.
Specimen S3E CGRP cKO-Wnt1: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1tm1.1Abr (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: spinal nerve dorsal root sensory neuron of spinal nerve Present Regionally restricted S3E CGRP cKO-Wnt1 No change in central branch innervation compared to control.
Specimen S3I CGRP Control: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted S3I CGRP Control Expression in differentiated sensory neurons.
Specimen S3I GCRP cKO-Wnt1: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1tm1.1Abr (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted S3I CGRP cKO-Wnt1 No change in differentiation compare to control
Specimen S6C CGRP +/+: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: spinal cord Present Regionally restricted S6C CGRP +/+ Expression in differentiated sensory neurons.
Specimen S6C CGRP L/L: postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Level Pattern Image Note
TS27: spinal cord Present Regionally restricted S6C CGRP L/L Expression unaffected compared to control.
Specimen S6E CGRP +/+: postnatal day 1 (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted S6E CGRP +/+ Expression in differentiated sensory neurons.
Specimen S6E CGRP L/L: postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present S6E CGRP L/L No significant difference in percentage of differentiated neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory