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Gene Expression Data
Assay Details
Assay
Reference: J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7529725
Gene symbol: Pvalb
Gene name: parvalbumin
Results
Specimen 3A PV Control: postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: spinal cord Present 3A PV Control Expression in large caliber proprioceptive afferent axons.
Specimen 3A PV cKO-Nes: postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: spinal cord Present 3A PV cKO-Nes Axons projected toward ventral motor pools in normal fashion.
Specimen 3E PV Control: postnatal day 1; Smad1tm1Abr/Smad1+ (more )
Structure Cell Type Level Pattern Image Note
TS27: thoracic dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 3E PV Control Expression in differentiated sensory neurons.
Specimen 3E PV cKO-Nes: postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: thoracic dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 3E PV cKO-Nes Total number of expressing-neurons similar to control.
Specimen S3E PV Control: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: spinal nerve dorsal root sensory neuron of spinal nerve Present Regionally restricted S3E PV Control Expression in central axon projections of dorsal root ganglion sensory neurons into spinal cord.
Specimen S3E PV cKO-Wnt1: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1tm1.1Abr (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: spinal nerve dorsal root sensory neuron of spinal nerve Present Regionally restricted S3E PV cKO-Wnt1 No changes in central branch innervation compared to control.
Specimen S3I PV Control: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted S3I PV Control Expression in differentiated sensory neurons.
Specimen S3I PV cKO-Wnt1: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1tm1.1Abr (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted S3I PV cKO-Wnt1 No changes in differentiation compared to control.
Specimen S6C PV +/+: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: spinal cord Present Regionally restricted S6C PV +/+ Expression in differentiated neurons.
Specimen S6C PV L/L: postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Level Pattern Image Note
TS27: spinal cord Present Regionally restricted S6C PV L/L Expression unaffected compared to control.
Specimen S6E PV +/+: postnatal day 1 (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present S6E PV +/+ Expression in differentiated neurons.
Specimen S6E PV L/L: postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present S6E PV L/L No significant difference in percentage of differentiated neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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