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Gene Expression Data
Assay Details
Assay
Reference: J:309492 Yaba A, et al., Expression of CCM2 and CCM3 during mouse gonadogenesis. J Assist Reprod Genet. 2015 Oct;32(10):1497-507
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7532723
Gene symbol: Ccm2
Gene name: cerebral cavernous malformation 2
Antibody: anti-CCM2
Detection system: Biotinylated secondary antibody/[Strept]avidin
Results
Specimen 1a: embryonic day 13.5 (more )
Structure Cell Type Level Pattern Image Note
TS21: interstitium of the testis interstitial cell Present 1a
TS21: germ cell of testis Absent 1a
TS21: Sertoli cell Sertoli cell Absent 1a

Specimen 1b: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: interstitium of the testis interstitial cell Present 1b
TS22: germ cell of testis Present 1b
TS22: Sertoli cell Sertoli cell Present 1b

Specimen 1c: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: seminiferous cord Present 1c Increased expression.
TS23: interstitium of the testis interstitial cell Moderate 1c Moderate nuclear expression in interstitial cells around the cords.
TS23: germ cell of testis Moderate 1c Moderate nuclear expression in some gonocytes.

Specimen 1d: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: germ cell of testis Present 1d
TS25: Sertoli cell Sertoli cell Absent 1d
TS25: interstitium of the testis interstitial cell Present 1d

Specimen 1e: postnatal day 0.5 (more )
Structure Cell Type Level Pattern Image Note
TS27: germ cell of testis Absent 1e
TS27: interstitium of the testis interstitial cell Present 1e Some of the interstitial cells expressed in the nuclei and cytoplasm.

Specimen 1f: postnatal day 3 (more )
Structure Cell Type Level Pattern Image Note
TS27: interstitium of the testis interstitial cell Present 1f Some of the interstitial cells expressed in the nuclei and cytoplasm.
TS27: germ cell of testis Present Regionally restricted 1f Expressed in the cytoplasm of some gonocytes in the basal side of the tubule.

Specimen 1g: postnatal day 5 (more )
Structure Cell Type Level Pattern Image Note
TS28: interstitium of the testis interstitial cell Present 1g Cytoplasmic expression.
TS28: spermatocyte Present Regionally restricted 1g Cytoplasmic expression in gonocytes located at the center of the seminiferous cords.
TS28: spermatogonium Absent 1g Not expressed in the spermatogonial cells at the basal side.

Specimen 1h: postnatal day 9 (more )
Structure Cell Type Level Pattern Image Note
TS28: primary spermatocyte Present 1h Expressed in the nuclei of pachytene spermatocytes.
TS28: spermatid Present 1h Round spermatids also showed nuclear expression in different seminiferous tubules.
TS28: interstitium of the testis interstitial cell Present 1h Nuclear and cytoplasmic staining in different areas.

Specimen 1i: postnatal day 15 (more )
Structure Level Pattern Image Note
TS28: primary spermatocyte Present 1i Expressed in the nuclei of preleptotene and pachytene spermatocytes.

Specimen 1j: postnatal day 20 (more )
Structure Level Pattern Image Note
TS28: spermatid Present 1j Cytoplasmic expression in round spermatids.

Specimen 1k: postnatal adult (more )
Structure Level Pattern Image Note
TS28: spermatocyte Present 1k Nuclear and cytoplasmic expression in elongated spermatocytes at stages II-III, IX, and X.

Specimen 3a: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: oocyte Present 3a

Specimen 3c: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: oocyte Present 3c

Specimen 3e: postnatal day 5 (more )
Structure Cell Type Level Pattern Image Note
TS28: oocyte Present 3e Expressed in the oocyte nuclei of primordial follicles and growing transient follicles.
TS28: follicle cell of primordial follicle Present 3e Expressed in pregranulosa cells.
TS28: follicle cell of primary follicle granulosa cell Present 3e
TS28: follicle cell of secondary follicle granulosa cell Present 3e
TS28: oocyte of primary follicle Strong 3e Nuclear expression.

Specimen 3g: postnatal day 9 (more )
Structure Cell Type Level Pattern Image Note
TS28: oocyte Present 3g Nuclear expression.
TS28: follicle cell of primary follicle granulosa cell Present 3g
TS28: follicle cell of secondary follicle granulosa cell Present 3g

Specimen 3i: postnatal week 12 (more )
Structure Cell Type Level Pattern Image Note
TS28: oocyte of antral follicle Absent 3i Not expressed in grown oocytes in further-developed follicles.
TS28: ovary follicle cell granulosa cell Present 3i Cytoplasmic expression.
TS28: corpus luteum luteal cell Present 3i Cytoplasmic expression.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory