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Gene Expression Data
Assay Details
Assay
Reference: J:198274 Mikelis CM, et al., PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem. 2013 Apr 26;288(17):12232-43
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7545300
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 2B Prg+/+ Larg+/+: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: head blood vessel Present 2B Prg+/+ Larg+/+ (upper) , 2B Prg+/+ Larg+/+ (lower)
Specimen 2B Prg-/- Larg+/+: embryonic day 10.0; Arhgef11tm1Sgkd/Arhgef11tm1Sgkd (more )
Structure Level Pattern Image Note
TS16: head blood vessel Present 2B Prg-/- Larg+/+ (lower) , 2B Prg-/- Larg+/+ (upper)
Specimen 2B Prg-/- Larg-/-: embryonic day 10.0; Arhgef11tm1Sgkd/Arhgef11tm1Sgkd, Arhgef12tm1Sgkd/Arhgef12tm1Sgkd (more )
Structure Level Pattern Image Note
TS16: head blood vessel Present Regionally restricted 2B Prg-/- Larg-/- (lower) , 2B Prg-/- Larg-/- (upper) Authors report partial branching failure in two of six cranial vessels, resulting in less overall vessel branching in the head.
Specimen 2C Prg+/+ Larg+/+: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: trunk blood vessel Present 2C Prg+/+ Larg+/+
Specimen 2C Prg-/- Larg+/+: embryonic day 10.0; Arhgef11tm1Sgkd/Arhgef11tm1Sgkd (more )
Structure Level Pattern Image Note
TS16: trunk blood vessel Present 2C Prg-/- Larg+/+
Specimen 2C Prg-/- Larg-/-: embryonic day 10.0; Arhgef11tm1Sgkd/Arhgef11tm1Sgkd, Arhgef12tm1Sgkd/Arhgef12tm1Sgkd (more )
Structure Level Pattern Image Note
TS16: trunk blood vessel Present 2C Prg-/- Larg-/- No obvious abnormality in trunk blood vessels.
Specimen 3B Prg-/- Larg+/+: embryonic day 10.0; Arhgef11tm1Sgkd/Arhgef11tm1Sgkd (more )
Structure Level Pattern Image Note
TS16: yolk sac blood vessel Present 3B Prg-/- Larg+/+
Specimen 3B Prg-/- Larg-/-: embryonic day 10.0; Arhgef11tm1Sgkd/Arhgef11tm1Sgkd, Arhgef12tm1Sgkd/Arhgef12tm1Sgkd (more )
Structure Level Pattern Image Note
TS16: yolk sac blood vessel Present Regionally restricted 3B Prg-/- Larg-/- Vascular plexus is disorganized and less developed, with dilated and not well oriented vessels.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory