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Gene Expression Data
Assay Details
Assay
Reference: J:264015 Roy AR, et al., The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells. J Biol Chem. 2018 Jun 1;293(22):8449-8461
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7624266
Gene symbol: Iscu
Gene name: iron-sulfur cluster assembly enzyme
Results
Specimen 6I Ctcf fl/+; Tie2-Cre; Rosa mT/mG/+: embryonic day 10.5; Ctcftm2Gal/Ctcf+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Tg(Tek-cre)#Rwng/0 (more )
Note: Conditional mutant. Double labeled: red - Iscu; green - Pecam1 (assay MGI:7624263).
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone blood vessel endothelial cell Present 6I Ctcf fl/+ (upper) , 6I Ctcf fl/+ (lower)
Specimen 6I Ctcf fl/fl; Tie2-Cre; Rosa mT/mG/+: embryonic day 10.5; Ctcftm2Gal/Ctcftm2Gal, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Tg(Tek-cre)#Rwng/0 (more )
Note: Conditional mutant. Double labeled: red - Iscu; green - Pecam1 (assay MGI:7624263).
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone blood vessel endothelial cell Weak 6I Ctcf fl/fl (lower) , 6I Ctcf fl/fl (upper) Decreased expression in endothelial cell nuclei compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory