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Gene Expression Data
Assay Details
Assay
Reference: J:312371 Da Silva F, et al., Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J. 2021 Oct 1;40(19):e108041
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643183
Gene symbol: Sox4
Gene name: SRY (sex determining region Y)-box 4
Antibody: SOX4 Antibody (C15310129)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5B Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Double labeled: green - Sox4; red - pHH3.
Structure Level Pattern Image Note
TS21: neocortex Present 5B Co Sox4 , 5B Co merge
Specimen 5B DKO: embryonic day 13.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Note: Double labeled: green - Sox4; red - pHH3.
Structure Level Pattern Image Note
TS21: neocortex Present 5B DKO Sox4 , 5B DKO merge Expression was greatly reduced in pHH3+ cells.
Specimen Ev5 D: embryonic day 13.5 (more )
Note: Triple labeled: green - Sox4; red - Eomes (assay MGI:7643180); magenta - pHH3.
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present EV5_D left , EV5_D right , EV5_D middle Expression was concentrated in mitotic basal progenitors.
TS21: cerebral cortex ventricular layer neural progenitor cell Present EV5_D middle , EV5_D right , EV5_D left Expression was enriched in mitotic apical progenitors.
Specimen not shown Co: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Note: Quantified in Ev5 E.
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present Expressed in basal progenitors.
Specimen not shown DKO: embryonic day 13.5; Ccnytm1.1Smoc/Ccnytm1.1Smoc, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi (more )
Note: Quantified in Ev5 E.
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex subventricular zone neural progenitor cell Present Expression in non-mitotic basal progenitors was similar as in the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory