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Gene Expression Data
Assay Details
Assay
Reference: J:195264 Vincentz JW, et al., Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest. PLoS Genet. 2013 Mar;9(3):e1003405
Assay type: RNA in situ
MGI Accession ID: MGI:7643410
Gene symbol: Smad6
Gene name: SMAD family member 6
Probe: Smad6 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen S2C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: outflow tract endocardial cushion Present Regionally restricted S2C Expression was detected in aorticopulmonary cushion mesenchyme.
Specimen S2D: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/0, Twist1tm1Bhr/Twist1tm2Bhr (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: outflow tract endocardial cushion Present Regionally restricted S2D Conditional ablation of Twist1 produces abnormal cellular aggregates. Expression of Smad6 was absent from the aggregates, but was expressed in surrounding ecto-mesenchyme.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory