About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:195264 Vincentz JW, et al., Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest. PLoS Genet. 2013 Mar;9(3):e1003405
Assay type: RNA in situ
MGI Accession ID: MGI:7643416
Gene symbol: Hand1
Gene name: heart and neural crest derivatives expressed 1
Probe: Hand1 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2A: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS19: outflow tract endocardial cushion neural crest cell Present 2A
Specimen 2B: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/0, Twist1tm1Bhr/Twist1tm2Bhr (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: outflow tract endocardial cushion neural crest cell Present Regionally restricted 2B Conditional ablation of Twist1 produces abnormal cellular aggregates. Expression of Hand1 was detected in the aggregates.
Specimen 4E: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS19: sympathetic ganglion sympathetic neuron Present 4E1 , 4E
TS19: outflow tract endocardial cushion Ambiguous 4E , 4E2
Specimen 4F: embryonic day 11.5; Hand2tm1Cse/Hand2+, Twist1tm1Bhr/Twist1tm2Bhr, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: sympathetic ganglion sympathetic neuron Present 4F , 4F1
TS19: outflow tract endocardial cushion Strong Regionally restricted 4F2 , 4F Expression was detected in ectopic sympathetic-like neurons.
Specimen 4G: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/0, Hand2tm1Cse/Hand2tm1Dsr, Twist1tm2Bhr/Twist1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: sympathetic ganglion sympathetic neuron Absent 4G1 , 4G
TS19: outflow tract endocardial cushion Ambiguous 4G , 4G2
Specimen 4H: embryonic day 11.5; Hand2tm1Cse/Hand2tm1Dsr, Twist1tm1Bhr/Twist1tm2Bhr, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: sympathetic ganglion sympathetic neuron Absent 4H1 , 4H
TS19: outflow tract endocardial cushion Strong Regionally restricted 4H , 4H2 Expression was detected in ectopic sympathetic-like neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory