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Gene Expression Data
Assay Details
Assay
Reference: J:339076 Meng H, et al., Evidence for developmental vascular-associated necroptosis and its contribution to venous-lymphatic endothelial differentiation. Front Cell Dev Biol. 2023;11:1229788
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643484
Gene symbol: Prox1
Gene name: prospero homeobox 1
Antibody: PROX1 antibody [EPR19273] (ab199359)
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 3E WT: postnatal day 7 (more )
Note: Double labeled: magenta - Prox1; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS28: cerebral cortex Present Regionally restricted 3E WT Expressed in cells localized at the upper layers.
Specimen 3E KO: postnatal day 7; Mlklem1Jhan/Mlklem1Jhan (more )
Note: Double labeled: magenta - Prox1; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS28: cerebral cortex Present 3E KO A much deeper distribution and bigger number of positive cells were observed.
Specimen 4E WT: postnatal day 7 (more )
Note: Double labeled: magenta - Prox1; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS28: epidermis Present 4E WT Positive cells localized mainly in the epidermal layer.
Specimen 4E KO: postnatal day 7; Mlklem1Jhan/Mlklem1Jhan (more )
Note: Double labeled: magenta - Prox1; green - Pecam1 (assay MGI:7643480).
Structure Level Pattern Image Note
TS28: skin Present 4E KO Positive cells expanded beyond epidermal layer and even into mesenchyme layers.
TS28: epidermis Present 4E KO More positive cells compared with the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory