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Gene Expression Data
Assay Details
Assay
Reference: J:344830 Tsutsumi-Arai C, et al., A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2. J Dent Res. 2024 Jan;103(1):91-100
Assay type: RNA in situ
MGI Accession ID: MGI:7645407
Gene symbol: Col10a1
Gene name: collagen, type X, alpha 1
Probe: Mm-Col10a1 (426181)
Probe preparation: Antisense
Assay notes: RNAscope assay (Opal520).
Results
Specimen 1D: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Multi-labeled: green - Col10a1; red - Pthlh reporter (assay MGI:7645376); blue - Runx2 (assay MGI:7645408); magenta - Sox9 (assay MGI:7645405).
Structure Cell Type Level Pattern Image Note
TS27: mandible condylar process hypertrophic chondrocyte Present Regionally restricted 1D , 1d2 Expression is in the upper hypertrophic layer.
Specimen 4A Control E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: green - Col10a1; red - Pthlh reporter (assay MGI:7645376).
Structure Cell Type Level Pattern Image Note
TS23: mandible condylar process hypertrophic chondrocyte Present Regionally restricted 4A E15.5 Control Expression is in hypertrophic chondrocytes.
Specimen 4A KO E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: green - Col10a1; red - Pthlh reporter (assay MGI:7645376).
Structure Cell Type Level Pattern Image Note
TS23: mandible condylar process hypertrophic chondrocyte Present Regionally restricted 4A E15.5 KO The expression domain has expanded in this mutant compared to controls.
Specimen 4A Control E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: green - Col10a1; red - Pthlh reporter (assay MGI:7645376).
Structure Cell Type Level Pattern Image Note
TS26: mandible condylar process hypertrophic chondrocyte Present Regionally restricted 4A E18.5 Control Expression is in hypertrophic chondrocytes.
Specimen 4A KO E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: green - Col10a1; red - Pthlh reporter (assay MGI:7645376).
Structure Cell Type Level Pattern Image Note
TS26: mandible condylar process hypertrophic chondrocyte Present Regionally restricted 4A E18.5 KO The expression domain is reduced in this mutant compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/22/2024
MGI 6.24 		The Jackson Laboratory