Atf4 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:321836 Zhao K, et al., LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development. Development. 2022 Mar 15;149(6):dev200458
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7711996
Gene symbol:	Atf4
Gene name:	activating transcription factor 4

Antibody:	anti-ATF4 (11815)
Detection system:	Secondary antibody

Results

5E1 ©

5E2 ©

5E E9.5 ATF4 Ctrl ©

Specimen 5E E9.5 Ctrl: embryonic day 9.5 (more

)

Structure	Level	Pattern	Image	Note
TS15: cardiac muscle tissue	Present		5E2 , 5E1 , 5E E9.5 ATF4 Ctrl

5E5 ©

5E6 ©

5E E10.5 ATF4 Ctrl ©

Specimen 5E E10.5 Ctrl: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: heart	Present		5E E10.5 ATF4 Ctrl , 5E6 , 5E5

5E9 ©

5E10 ©

5E E12.5 ATF4 Ctrl ©

Specimen 5E E12.5 Ctrl: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: heart	Present		5E9 , 5E E12.5 ATF4 Ctrl , 5E10

5E3 ©

5E4 ©

5E E9.5 ATF4 cKO ©

Specimen 5E E9.5 cKO: embryonic day 9.5; Lonp1^tm1.1Zzy/Lonp1^tm1.1Zzy, Tg(Tnnt2-cre)5Blh/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS15: heart	Present		5E E9.5 ATF4 cKO , 5E3 , 5E4

5E7 ©

5E8 ©

5E E10.5 ATF4 cKO ©

Specimen 5E E10.5 cKO: embryonic day 10.5; Lonp1^tm1.1Zzy/Lonp1^tm1.1Zzy, Tg(Tnnt2-cre)5Blh/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS17: heart	Present		5E8 , 5E7 , 5E E10.5 ATF4 cKO	Increased expression in both the nucleus and cytoplasm, compared with the control.

5E11 ©

5E12 ©

Specimen 5E E12.5 cKO: embryonic day 12.5; Lonp1^tm1.1Zzy/Lonp1^tm1.1Zzy, Tg(Tnnt2-cre)5Blh/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: heart	Present		5E12 , 5E11 , 5E E12.5 ATF4 cKO	Increased expression in both the nucleus and cytoplasm, compared with the control.

S5A Ctrl ©

S5A' ©

Specimen S5A Ctrl: embryonic day 14.5 (more

)
Note: Double labeled: green - Atf4; red - Tnnt2 (assay MGI:7711946).

Structure	Level	Pattern	Image	Note
TS22: heart right ventricle	Present		S5A' , S5A Ctrl

S5A cKO ©

S5A" ©

Specimen S5A cKO: embryonic day 14.5; Lonp1^tm1.1Zzy/Lonp1^tm1.1Zzy, Tg(Mef2c-cre)2Blk/0 (more

)
Note: Conditional mutant. Double labeled: green - Atf4; red - Tnnt2 (assay MGI:7711946).

Structure	Level	Pattern	Image	Note
TS22: heart right ventricle	Present		S5A cKO , S5A"	Increased expression in both the nucleus and cytoplasm, compared with the control.

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