Parkinson's disease 1 Disease Ontology Browser

Disease Ontology Browser

Parkinson's disease 1 (DOID:0060367)
Alliance: disease page
Synonyms: autosomal dominant Parkinson disease 1; autosomal dominant Parkinson's disease 1
Alt IDs: OMIM:168601
Definition: A late onset Parkinson's disease that has_material_basis_in mutation in the alpha-synuclein gene on chromosome 4q22.1.

Term Browser
Genes (2)
Models (26)

Disease References using Mouse Models (63)

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Gene: Snca

Allelic Composition	Genetic Background	Reference	Phenotypes
Sncatm1Nbm/Sncatm1Nbm Tg(SNCAA30P)1Nbm/Tg(SNCAA30P)1Nbm Tg(SNCAA30P)2Nbm/Tg(SNCAA30P)2Nbm	involves: 129S6/SvEvTac * FVB/N	J:156741	View
Sncatm1Nbm/Sncatm1Nbm Tg(SNCAA53T)1Nbm/Tg(SNCAA53T)1Nbm Tg(SNCAA53T)2Nbm/Tg(SNCAA53T)2Nbm	involves: 129S6/SvEvTac * FVB/N	J:156741	View
Sncatm1.1Koks/Snca+	either: B6.129P2-Snca^tm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6)	J:201391	View
Sncatm1Rosl/Sncatm1Rosl Tg(SNCA*A30P)192Rwm/0	B6.Cg-Snca^tm1Rosl Tg(SNCA*A30P)#Rwm	J:201961	View
Sncatm1Rosl/Sncatm1Rosl Tg(SNCA)OVX37Rwm/0	B6.Cg-Tg(SNCA)OVX37Rwm Snca^tm1Rosl	J:201991	View
Sncatm1Rosl/Sncatm1Rosl	involves: 129X1/SvJ * C57BL/6	J:60151	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(PDGFB-SNCA)4Ema

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(PDGFB-SNCA)4Ema/0	involves: C57BL/6 * DBA/2	J:60638, J:166985	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(PDGFB-SNCA*A53T)8Ema

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(PDGFB-SNCA*A53T)8Ema/0	Not Specified	J:226922	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(PDGFB-SNCA/EGFP)78Ema

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(PDGFB-SNCA/EGFP)78Ema/0	involves: C57BL/6 * DBA/2	J:238692	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(Prnp-SNCA*A53T)25Mkle

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-SNCA*A53T)25Mkle/0	involves: C3H/HeJ * C57BL/6J	J:77344	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(Prnp-SNCA*A53T)83Vle

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-SNCAA53T)83Vle/Tg(Prnp-SNCAA53T)83Vle	involves: C3H * C57BL/6	J:76657	View
Tg(Prnp-SNCA*A53T)83Vle/0	involves: C3H * C57BL/6	J:76657	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(Prnp-SNCA*A53T)AAub

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-SNCAA53T)AAub/Tg(Prnp-SNCAA53T)AAub	involves: FVB/N	J:181820, J:185489	View
Tg(Prnp-SNCA*A53T)AAub/?	involves: FVB/N	J:216589	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(SNCA)ARyot

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(SNCA)ARyot/0	C57BL/6J-Tg(SNCA)ARyot	J:185434	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(SNCA*E46K)3Elan

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(SNCA*E46K)3Elan/?	involves: C57BL/6 * SJL	J:200740	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(Snca-SNCA)#Galt

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Snca-SNCA)#Galt/?	involves: C57BL/6 * DBA/2	J:199939	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(Th-SNCA*)1702Yosh

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Th-SNCA*)1702Yosh/0	involves: C3H * C57BL/6J	J:125149	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(Thy1-SNCA)61Ema

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-SNCA)61Ema/0	involves: C57BL/6 * DBA/2	J:137490	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(Thy1-SNCA*)#Ztzh

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-SNCA*)#Ztzh/0	involves: C57BL/6J	J:313970	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(Thy1-SNCA*A30P)18Pjk

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-SNCAA30P)18Pjk/Tg(Thy1-SNCAA30P)18Pjk	involves: C57BL/6	J:80181	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(THY1-SNCA*A53T)M53Sud

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(THY1-SNCA*A53T)M53Sud/0	B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J	J:212732	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1
Associated Mouse Transgene: Tg(Thy1-SNCA*E57K)16Ema

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-SNCA*E57K)16Ema/0	involves: C57BL/6 * DBA/2	J:236596	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1

Allelic Composition	Genetic Background	Reference	Phenotypes
Gt(ROSA)26Sortm2(SNCA119)Djmo/Gt(ROSA)26Sortm2(SNCA119)Djmo 7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+	involves: 129 * C57BL/6	J:150777	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1

Allelic Composition	Genetic Background	Reference	Phenotypes
Gt(ROSA)26Sortm2(SNCA119)Djmo/Gt(ROSA)26Sortm2(SNCA119)Djmo 7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+	involves: 129 * C57BL/6 * SJL	J:150777	View

Mouse Models

Human Disease Modeled: Parkinson's disease 1

Allelic Composition	Genetic Background	Reference	Phenotypes
2310039L15RikTg(Prnp-SNCA*A53T)23Mkle/2310039L15Rik+	involves: C3H/HeJ * C57BL/6J	J:77344	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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