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Disease Ontology Browser
hereditary combined deficiency of vitamin K-dependent clotting factors (DOID:0112172)
Alliance: disease page
Synonyms: hereditary combined deficiency of factors II, VII, IX and X; VKCFD
Alt IDs: ORDO:98434, UMLS_CUI:C4510617
Definition: A blood coagulation disease characterized by reduced hepatic gamma-carboxylation of glutamic acid residues of all vitamin K-dependent blood coagulation factors and the anticoagulant factors protein C and protein S resulting in a bleeding tendency that is usually reversed by oral administration of vitamin K that has_material_basis_in a heritable mutation.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory