Parkinson's disease Disease Ontology Browser

Disease Ontology Browser

Parkinson's disease (DOID:14330)
Alliance: disease page
Synonyms: paralysis agitans; Parkinson disease
Alt IDs: ICD10CM:G20, ICD9CM:332, ICD9CM:332.0, KEGG:05012, MESH:D010300, NCI:C26845, OMIM:PS168600, ORDO:2828, UMLS_CUI:C0030567
Definition: A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.

Term Browser
Genes (115)
Models (93)

Disease References using Mouse Models (162)

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Adcy5

Allelic Composition	Genetic Background	Reference	Phenotypes
Adcy5tm1Yish/Adcy5tm1Yish	involves: 129X1/SvJ * C57BL/6	J:83301	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Adh7

Allelic Composition	Genetic Background	Reference	Phenotypes
Adh7tm1Gdu/Adh7tm1Gdu	B6.129(Cg)-Adh7^tm1Gdu	J:167234	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Atg7

Allelic Composition	Genetic Background	Reference	Phenotypes
Atg7tm1Tchi/Atg7tm1Tchi En1tm2(cre)Wrst/En1+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj	J:192452	View
Atg7tm1Tchi/Atg7tm1Tchi Slc6a3tm1(cre)Xz/Slc6a3+	involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj	J:192452	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Cox10

Allelic Composition	Genetic Background	Reference	Phenotypes
Cox10tm1Ctm/Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn/?	B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}	J:231810	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Drd2

Allelic Composition	Genetic Background	Reference	Phenotypes
Drd2tm1Ebo/Drd2tm1Ebo	involves: 129S2/SvPas * C57BL/6	J:29045	View

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
Drd2tm1Low/Drd2tm1Low	B6.129S2-Drd2^tm1Low	J:47001	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Kcnn2

Allelic Composition	Genetic Background	Reference	Phenotypes
Kcnn2fri/Kcnn2fri	involves: C3H	J:70213	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Minar2

Allelic Composition	Genetic Background	Reference	Phenotypes
Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi	C57BL/6N-Minar2^{tm1b(KOMP)Wtsi}/Wtsi	J:298983	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: nm3

Allelic Composition	Genetic Background	Reference	Phenotypes
nm3/nm3	involves: RIIIS/J	J:88298	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Pitx3

Allelic Composition	Genetic Background	Reference	Phenotypes
Pitx3eyl/Pitx3eyl	involves: C3H/He * C57BL/6	J:156878	View
Pitx3tm1.1Cai/Pitx3+ Tg(tetO-SNCA*A53T)E2Cai/0	involves: 129 * C57BL/6J * FVB/N	J:185958	View
Pitx3ak/Pitx3ak	involves: 129S1/Sv * C57BL/6 * C57BLKS/J	J:98209	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Rrn3

Allelic Composition	Genetic Background	Reference	Phenotypes
Rrn3tm1.1Igt/Rrn3tm1.1Igt Tg(Slc6a3-icre)9190Gsc/0	involves: 129/Sv * C57BL/6 * FVB/N	J:168232	View
Rrn3tm1.1Igt/Rrn3tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0	involves: 129/Sv * C57BL/6	J:168232, J:242309	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Spr

Allelic Composition	Genetic Background	Reference	Phenotypes
Sprtm1Lex/Sprtm1Lex	involves: 129S/SvEvBrd * C57BL/6J	J:131376	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Twnk

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Th-Twnk*,-EGFP)2Gcor/0	involves: C57BL/6J	J:188914	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: En1

Allelic Composition	Genetic Background	Reference	Phenotypes
En1tm2Alj/En1+ Tg(Th-EGFP)6-7Okn/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J * OF1	J:214073	View
Atg7tm1Tchi/Atg7tm1Tchi En1tm2(cre)Wrst/En1+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj	J:192452	View
En1tm1Gld/En1+ En2tm1Alj/En2tm1Alj	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster	J:115270	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Nr4a2

Allelic Composition	Genetic Background	Reference	Phenotypes
Nr4a2tm1Omc/Nr4a2+	involves: 129S7/SvEvBrd * C57BL/6	J:104902	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Ppargc1a

Allelic Composition	Genetic Background	Reference	Phenotypes
Ppargc1atm1Dpk/Ppargc1atm1Dpk	B6.129X1-Ppargc1a^tm1Dpk/J	J:298664	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Tfam

Allelic Composition	Genetic Background	Reference	Phenotypes
Slc6a3tm1(cre)Lrsn/Slc6a3+ Tfamtm1Lrsn/Tfamtm1Lrsn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	J:119515	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Gene: Vps35

Allelic Composition	Genetic Background	Reference	Phenotypes
Vps35tm1.1Mjff/Vps35tm1.1Mjff	B6.Cg-Vps35^tm1.1Mjff	J:303283	View

Mouse Models

Human Disease Modeled: Parkinson's disease

Allelic Composition	Genetic Background	Reference	Phenotypes
Pink1tm1.1Wrst/Pink1tm1.1Wrst Tg(Prnp-SNCA*A53T)AAub/?	involves: 129S2/SvPas * C57BL/6J * FVB/N	J:242309	View
Pink1tm1Aub/Pink1tm1Aub Tg(Prnp-SNCAA53T)AAub/Tg(Prnp-SNCAA53T)AAub	involves: 129S/SvEv * FVB/N	J:214065	View

Mouse Models

Human Disease Modeled: Parkinson's disease

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-Snca)1S13Putt/0 Uchl1tm1Dgen/Uchl1tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	J:207278	View

Mouse Models

Human Disease Modeled: Parkinson's disease

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-Snca)1S13Putt/0 Uchl1tm1Dgen/Uchl1tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	J:207278	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(CAG-SNCA*)1.1Ccs

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CAG-SNCA*)1.1Ccs/?	involves: C57BL/6	J:168847	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(DBH-SNCA)#Dwei

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(DBH-SNCA)#Dwei/0	C57BL/6N-Tg(DBH-SNCA)#Dwei	J:296218	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/0	involves: C57BL/6	J:132679	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(PDGF-S100B)36Cqin

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(PDGF-S100B)36Cqin/0	C57BL/6-Tg(PDGF-S100B)36Cqin	J:173682	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(Snca-SNCA/GFP)#Jyl

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Snca-SNCA/GFP)#Jyl/Tg(Snca-SNCA/GFP)#Jyl	involves: C57BL/6	J:197984	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(tetO-HMOX1)6Hyms

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(GFAP-tTA)6Hyms/0 Tg(tetO-HMOX1)6Hyms/0	involves: FVB/N	J:190573	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(tetO-SNCA)0Olri

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-SNCA)0Olri/0	involves: C57BL/6	J:132774	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(Th-SNCA)5Eric

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Th-SNCA)5Eric/Tg(Th-SNCA)5Eric	involves: C57BL/6	J:140907	View
Tg(Th-SNCA)5Eric/0	involves: C57BL/6 * C57BL/6J	J:96494	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(Th-SNCA*)1.2Ccs

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Th-SNCA*)1.2Ccs/?	involves: C57BL/6	J:168847	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(Th-SNCA*A30P*A53T)39Eric

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Th-SNCAA30PA53T)39Eric/0	involves: C57BL/6 * C57BL/6J	J:96494	View

Mouse Models

Human Disease Modeled: Parkinson's disease
Associated Mouse Transgene: Tg(Th-Twnk*,-EGFP)2Gcor

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Th-Twnk*,-EGFP)2Gcor/0	involves: C57BL/6J	J:188914	View

Mouse Models

Human Disease Modeled: Parkinson's disease

Allelic Composition	Genetic Background	Reference	Phenotypes
Slc6a3tm2(tTA)Xz/Slc6a3+ Tg(tetO-COX8A/PstI*)1Ctm/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL	J:178139	View

Mouse Models

Human Disease Modeled: Parkinson's disease

Allelic Composition	Genetic Background	Reference	Phenotypes
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+ Mfn2tm3Dcc/Mfn2tm3Dcc Slc6a3tm1.1(cre)Bkmn/Slc6a3+	involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J	J:188347	View

Mouse Models

Human Disease Modeled: Parkinson's disease

Allelic Composition	Genetic Background	Reference	Phenotypes
Lmx1atm1Tpe/Lmx1atm1Tpe Lmx1btm1Zfc/Lmx1btm1Zfc Slc6a3tm1(cre)Lrsn/Slc6a3+	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	J:222854	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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