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Disease Ontology Browser
malignant hyperthermia (DOID:8545)
Alliance: disease page
Synonyms: anesthesia related hyperthermia; malignant hyperpyrexia due to anesthesia
Alt IDs: ICD10CM:T88.3, ICD9CM:995.86, MESH:D008305, NCI:C84869, OMIM:PS145600, ORDO:423, UMLS_CUI:C0024591
Definition: A muscle tissue disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature and that has_material_basis_in heterozygous mutation in the ryanodine receptor gene (RYR1) on chromosome 19q13. Manifestations of malignant hyperthermia (MH) are precipitated by certain volatile anesthetics (i.e., halothane, isoflurane, sevoflurane, desflurane, enflurane), either alone or in conjunction with a depolarizing muscle relaxant (specifically, succinylcholine).

Disease References using Mouse Models (4)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory