psoriasis Disease Ontology Browser

Disease Ontology Browser

psoriasis (DOID:8893)
Alliance: disease page
Alt IDs: EFO:0000676, ICD10CM:L40, MESH:D011565, NCI:C3346, OMIM:PS177900, UMLS_CUI:C0033860
Definition: A skin disease that is characterized by patches of thick red skin and silvery scales.

Term Browser
Genes (47)
Models (42)

Disease References using Mouse Models (32)

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Gene: Stat3

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(KRT5-Stat3A661CN663C)1Jdg/0	involves: FVB	J:95458	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Gene: Vegfa

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(KRT14-Vegfa)3Dtm/0	FVB/N-Tg(KRT14-Vegfa)3Dtm	J:92643	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Gene: Arpc4

Allelic Composition	Genetic Background	Reference	Phenotypes
Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm/Krt14+	B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm	J:253986	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Gene: Itgb2

Allelic Composition	Genetic Background	Reference	Phenotypes
Itgb2tm1Bay/Itgb2tm1Bay	involves: 129S7/SvEvBrd * C57BL/6J * PL/J	J:32126, J:84126	View
Itgb2tm1Bay/Itgb2tm1Bay	involves: 129S7/SvEvBrd * PL/J	J:32126, J:109598	View
Itgb2tm2Bay/Itgb2tm2Bay	involves: 129S7/SvEvBrd * PL/J	J:84126	View
Itgb2tm1Bay/Itgb2tm2Bay	involves: 129S7/SvEvBrd * C57BL/6J * PL/J	J:84126	View
Itgb2tm1Bay/Itgb2tm2Bay	PL.129S7-Itgb2^tm1Bay Itgb2^tm2Bay	J:84126	View

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
Itgb2tm1Bay/Itgb2tm2Bay	B6.129S7-Itgb2^tm1Bay Itgb2^tm2Bay	J:84126	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Gene: S100a7a

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(KRT5-rtTA)#Glk/0 Tg(tetO-S100a7a)#Yus/0	involves: FVB/N	J:168000	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Gene: Sptlc2

Allelic Composition	Genetic Background	Reference	Phenotypes
Sptlc2tm1Yhir/Sptlc2tm1Yhir Tg(KRT5-cre)1Tak/0	involves: C3H * C57BL/6	J:202388	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Gene: Ttc7

Allelic Composition	Genetic Background	Reference	Phenotypes
Ttc7fsn/Ttc7fsn	involves: A/J * BALB/cByJ	J:14506	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(CAG-Lyn*)#Paau

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CAG-Lyn*)#Paau/0	B6.Cg-Tg(CAG-Lyn*)#Paau	J:151886	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(CYP1A1-PPARD)#Jfoe

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CYP1A1-PPARD)#Jfoe/0	involves: C57BL/6J * CBA	J:158907	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(ITGB1)0840Fmw

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(ITGB1)0840Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA2)1070Fmw/0 Tg(ITGB1)0840Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA2)1075Fmw/0 Tg(ITGB1)0840Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA2)1067Fmw/0 Tg(ITGB1)0840Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA5)0844Fmw/0 Tg(ITGB1)0840Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA5)0858Fmw/0 Tg(ITGB1)0840Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA5)0794Fmw/0 Tg(ITGB1)0840Fmw/0	involves: C57BL/10 * CBA	J:30249	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(ITGB1)0869Fmw

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(ITGB1)0869Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA2)1070Fmw/0 Tg(ITGB1)0869Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA2)1075Fmw/0 Tg(ITGB1)0869Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA2)1067Fmw/0 Tg(ITGB1)0869Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA5)0844Fmw/0 Tg(ITGB1)0869Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA5)0858Fmw/0 Tg(ITGB1)0869Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA5)0794Fmw/0 Tg(ITGB1)0869Fmw/0	involves: C57BL/10 * CBA	J:30249	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(ITGB1)0870Fmw

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(ITGB1)0870Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA2)1070Fmw/0 Tg(ITGB1)0870Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA2)1075Fmw/0 Tg(ITGB1)0870Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA2)1067Fmw/0 Tg(ITGB1)0870Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA5)0844Fmw/0 Tg(ITGB1)0870Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA5)0858Fmw/0 Tg(ITGB1)0870Fmw/0	involves: C57BL/10 * CBA	J:30249	View
Tg(ITGA5)0794Fmw/0 Tg(ITGB1)0870Fmw/0	involves: C57BL/10 * CBA	J:30249	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(KRT5-Stat3*A661C*N663C)1Jdg

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(KRT5-Stat3A661CN663C)1Jdg/0	involves: FVB	J:95458	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(KRT5-TGFB1)F2020Xjw

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(KRT5-TGFB1)F2020Xjw/0	involves: C57BL/6 * DBA/2 * ICR	J:90118	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(Krt14-Rac1*G12V)#Mrnk

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Krt14-Rac1*G12V)#Mrnk/0	either: B6.CBACa-Tg(Krt14-Rac1G12V)#Mrnk or C.CBACa-Tg(Krt14-Rac1G12V)#Mrnk	J:237134	View
Tg(Krt14-Rac1*G12V)#Mrnk/0	involves: CBA/CaJ	J:237134	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(KRT14-Vegfa)3Dtm

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(KRT14-Vegfa)3Dtm/0	FVB/N-Tg(KRT14-Vegfa)3Dtm	J:92643	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(tetO-S100a7a)#Yus

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(KRT5-rtTA)#Glk/0 Tg(tetO-S100a7a)#Yus/0	involves: FVB/N	J:168000	View

Mouse Models

Human Disease Modeled: psoriasis
Associated Mouse Transgene: Tg(tetO-Tek)1Dmt

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Tek-tTA)1Dmt/0 Tg(tetO-Tek)1Dmt/0	involves: CD-1	J:96718	View
Tg(KRT5-tTA)1216Glk/0 Tg(tetO-Tek)1Dmt/0	involves: CD-1 * FVB/N	J:147438	View

Mouse Models

Human Disease Modeled: psoriasis

Allelic Composition	Genetic Background	Reference	Phenotypes
Juntm4Wag/Juntm4Wag Junbtm3Wag/Junbtm3Wag Tg(Krt1-5-cre/ERT)1Ipc/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	J:116380	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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