type 2 diabetes mellitus Disease Ontology Browser

Disease Ontology Browser

type 2 diabetes mellitus (DOID:9352)
Alliance: disease page
Synonyms: insulin resistance; NIDDM; non-insulin-dependent diabetes mellitus; type 2 diabetes; type II diabetes mellitus
Alt IDs: OMIM:125853, OMIM:601283, OMIM:601407, OMIM:603694, OMIM:608036, ICD10CM:E11, KEGG:04930, MESH:D003924, NCI:C26747, UMLS_CUI:C0011860
Definition: A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.

Term Browser
Genes (209)
Models (52)

Disease References using Mouse Models (141)

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Akt2

Allelic Composition	Genetic Background	Reference	Phenotypes
Akt2tm1.1Mbb/Akt2tm1.1Mbb	involves: 129P2/OlaHsd * C57BL/6	J:71491	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Cdkal1

Allelic Composition	Genetic Background	Reference	Phenotypes
Cdkal1tm1.1Tomik/Cdkal1tm1.1Tomik Tg(Ins2-cre)25Mgn/0	B6.Cg-Cdkal1^tm1.1Tomik Tg(Ins2-cre)25Mgn	J:178248	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Cyb5r4

Allelic Composition	Genetic Background	Reference	Phenotypes
Cyb5r4tm1Hfb/Cyb5r4tm1Hfb	involves: 129S4/SvJae * BALB/cAnN	J:91486	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Gck

Allelic Composition	Genetic Background	Reference	Phenotypes
Gcktm1Tka/Gcktm1Tka	involves: 129X1/SvJ * ICR	J:30334	View
Gcktm1Tka/Gck+ Irs1tm1Tka/Irs1tm1Tka	involves: 129X1/SvJ * C57BL/6 * CBA * ICR	J:38899	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Hmga1

Allelic Composition	Genetic Background	Reference	Phenotypes
Hmga1tm1Brun/Hmga1tm1Brun	Not Specified	J:99652	View
Hmga1tm1Brun/Hmga1+	Not Specified	J:99652	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Hnf1a

Allelic Composition	Genetic Background	Reference	Phenotypes
Hnf1atm1.1Ylee/Hnf1atm1.1Ylee	involves: 129X1/SvJ * C57BL/6J	J:47008	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Iapp

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Ins2-IAPP)L13Gjsc/0	FVB/N-Tg(Ins2-IAPP)L13Gjsc	J:142009	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Ins2

Allelic Composition	Genetic Background	Reference	Phenotypes
Ins2Akita/?	involves: C57BL/6NSlc	J:130021	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Irs1

Allelic Composition	Genetic Background	Reference	Phenotypes
Irs1tm1Tka/Irs1tm1Tka	Not Specified	J:21373	View
Gcktm1Tka/Gck+ Irs1tm1Tka/Irs1tm1Tka	involves: 129X1/SvJ * C57BL/6 * CBA * ICR	J:38899	View
Irs1tm1Jos/Irs1+ Irs2tm2Mfw/Irs2tm2Mfw Tg(Ins2-cre)25Mgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:93415	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Irs2

Allelic Composition	Genetic Background	Reference	Phenotypes
Irs2tm1Tka/Irs2tm1Tka	involves: C57BL/6 * CBA	J:65485	View
Irs2tm1Mfw/Irs2tm1Mfw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	J:46134	View
Irs1tm1Jos/Irs1+ Irs2tm2Mfw/Irs2tm2Mfw Tg(Ins2-cre)25Mgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:93415	View
Irs2tm2Mfw/Irs2tm2Mfw Tg(Ins2-cre)25Mgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:93415	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Lep

Allelic Composition	Genetic Background	Reference	Phenotypes
Lepob/Lepob	BTBR.Cg-Lep^ob/WiscJ	J:106121	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Lepr

Allelic Composition	Genetic Background	Reference	Phenotypes
LeprTg(Mth11)1Aig/LeprTg(Mth11)1Aig	involves: Him:OF1	J:61119	View
Leprbrta/Leprbrta	C57BL/6JSfdAnu-Lepr^brta/Anu	J:104190	View
Leprtm1Jke/Leprtm1Jke	involves: 129X1/SvJ	J:216393	View
Leprdb/Leprdb	BKS.Cg-Dock7^m +/+ Lepr^db	J:346348	View
Leprdb/Leprdb	BKS.Cg-Dock7^m +/+ Lepr^db/J	J:185546	View
Leprdb/Leprdb	involves: C57BLKS/J	J:104790	View
Leprdb/Lepr+ Tg(APPswe,PSEN1dE9)85Dbo/0	involves: C3H * C57BL/6 * C57BLKS/J	J:186924	View
Leprdb/Leprdb Nos3tm1Unc/Nos3tm1Unc	BKS.Cg-Lepr^db Nos3^tm1Unc	J:135864	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Ppard

Allelic Composition	Genetic Background	Reference	Phenotypes
Ppardtm1Dsvg/Ppardtm1Dsvg	involves: 129S2/SvPas * C57BL/6	J:219677	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Ppp1r3a

Allelic Composition	Genetic Background	Reference	Phenotypes
Ppp1r3atm1Ptwc/Ppp1r3atm1Ptwc	involves: 129P2/OlaHsd * C57BL/6J	J:82422	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Slc2a2

Allelic Composition	Genetic Background	Reference	Phenotypes
Slc2a2tm1Thor/Slc2a2tm1Thor	involves: 129P2/OlaHsd * C57BL/6J	J:43839	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Slc2a4

Allelic Composition	Genetic Background	Reference	Phenotypes
Slc2a4tm1Mch/Slc2a4+	involves: 129/Sv * C57BL/6J * CD-1 * SJL	J:43650	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: a

Allelic Composition	Genetic Background	Reference	Phenotypes
Ay/a	involves: KK	J:26460	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Ar

Allelic Composition	Genetic Background	Reference	Phenotypes
Artm1Verh/Y Tg(Fabp4-cre)1Rev/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:196857	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Ctf1

Allelic Composition	Genetic Background	Reference	Phenotypes
Ctf1tm1Msd/Ctf1tm1Msd	B6.Cg-Ctf1^tm1Msd	J:176727	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Fem1b

Allelic Composition	Genetic Background	Reference	Phenotypes
Fem1btm1Jfma/Fem1btm1Jfma	involves: 129X1/SvJ * C57BL/6	J:100017	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Foxm1

Allelic Composition	Genetic Background	Reference	Phenotypes
Foxm1tm1Rhc/Foxm1tm1Rhc Tg(Pdx1-cre)89.1Dam/0	involves: 129X1/SvJ * C57BL/6 * CBA	J:111026	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Gadd45gip1

Allelic Composition	Genetic Background	Reference	Phenotypes
Gadd45gip1tm2Kong/Gadd45gip1tm2Kong Tg(Ins2-cre)25Mgn/0	involves: 129P2/OlaHsd * C57BL/6 * DBA	J:220742	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Htr2c

Allelic Composition	Genetic Background	Reference	Phenotypes
Htr2ctm1Jul/Y	B6.129S-Htr2c^tm1Jul	J:50262	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Madd

Allelic Composition	Genetic Background	Reference	Phenotypes
Maddtm1Bpra/Maddtm1Bpra Tg(Ins2-cre/ERT)1Dam/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	J:225256	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Mafa

Allelic Composition	Genetic Background	Reference	Phenotypes
Mafatm1Staka/Mafatm1Staka	involves: ICR	J:99126	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Nfe2l1

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Mafg-Nfe2l1)1Mym/0	involves: C57BL/6J * DBA/2	J:230118	View
Tg(Mafg-Nfe2l1)6Mym/0	involves: C57BL/6J * DBA/2	J:230118	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Phox2a

Allelic Composition	Genetic Background	Reference	Phenotypes
Phox2a/Inppl1tm1Ssch/Phox2a/Inppl1tm1Ssch	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:96443	View
Phox2a/Inppl1tm1Ssch/Phox2a+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:96443	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Ppp1r3c

Allelic Composition	Genetic Background	Reference	Phenotypes
Ppp1r3ctm1Ars/Ppp1r3c+	B6.129-Ppp1r3c^tm1Ars	J:83297	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Prkci

Allelic Composition	Genetic Background	Reference	Phenotypes
Prkcitm1Rfar/Prkci+ Tg(Ckmm-cre)5Khn/?	involves: 129P2/OlaHsd * C57BL/6 * FVB	J:123964	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Sdhb

Allelic Composition	Genetic Background	Reference	Phenotypes
Sdhbtm1c(EUCOMM)Hmgu/Sdhbtm1c(EUCOMM)Hmgu Tg(Ins2-cre)23Herr/0	involves: C57BL/6J * C57BL/6N * CBA/J	J:326592	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Gene: Snap25

Allelic Composition	Genetic Background	Reference	Phenotypes
Snap25tm1.1Bark/Snap25tm1.1Bark	Not Specified	J:226064	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus

Allelic Composition	Genetic Background	Reference	Phenotypes
Insrtm1Dac/Insr+ Ppp2r2aigt10/Ppp2r2a+	involves: 129S4/SvJae * C3H/HeH * C57BL/6J	J:246319	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus

Allelic Composition	Genetic Background	Reference	Phenotypes
Pdx1tm1Cvw/Pdx1+ Pbx1tm1Mlc/Pbx1+	involves: 129S6/SvEvTac * C57BL/6	J:75811	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Transgene: Tg(aP2-SREBF1c)9884Reh

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(aP2-SREBF1c)9884Reh/0	involves: C57BL/6J * SJL	J:50770	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Transgene: Tg(Ckm-IGF1R*K1003R)1Dlr

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Ckm-IGF1R*K1003R)1Dlr/0	FVB/N-Tg(Ckm-IGF1R*K1003R)1Dlr	J:71205, J:210518	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Transgene: Tg(Ins2-IAPP)L13Gjsc

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Ins2-IAPP)L13Gjsc/0	FVB/N-Tg(Ins2-IAPP)L13Gjsc	J:142009	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Transgene: Tg(Mafg-Nfe2l1)1Mym

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Mafg-Nfe2l1)1Mym/0	involves: C57BL/6J * DBA/2	J:230118	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Transgene: Tg(Mafg-Nfe2l1)6Mym

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Mafg-Nfe2l1)6Mym/0	involves: C57BL/6J * DBA/2	J:230118	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Transgene: Tg(UcpDta)1Kz

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(APOB)11Rub/0 Tg(UcpDta)1Kz/0	involves: C57BL/6J * FVB/N	J:78211	View
Tg(UcpDta)1Kz/?	involves: FVB/N	J:78211	View

Mouse Models

Human Disease Modeled: type 2 diabetes mellitus
Associated Mouse Other Genome Feature: Timo

Allelic Composition	Genetic Background	Reference	Phenotypes
Timo/Timo	either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ)	J:127183	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24