Lewy body dementia Disease Ontology Browser

Disease Ontology Browser

Lewy body dementia (DOID:12217)
Alliance: disease page
Synonyms: Dementia with Lewy bodies; Diffuse Lewy body disease; Lewy body disease; Senile dementia of the Lewy body type
Alt IDs: OMIM:127750, ICD10CM:G31.83, ICD9CM_2006:331.82, ICD9CM:331.82, MESH:D020961, NCI:C84826, UMLS_CUI:C0752347
Definition: A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities that has_material_basis_in accumulation of alpha-synuclein, SCNA, (protein). The causal mutation might be in SCNA or SCNB or some other gene(s) but the end result is always accumulation of SCNA in Lewy bodies.

Disease References using Mouse Models (8)

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Camk2a-SNCA*)2Mgsp/0 Del(6Snca)1Slab/Del(6Snca)1Slab	B6JOlaHsd.Cg-Tg(Camk2a-SNCA*)2Mgsp	J:219640	View

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(PDGFB-SNCA)4Ema/0	involves: C57BL/6 * DBA/2	J:60638, J:137490, J:166985	View

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(PDGFB-SNCA/EGFP)78Ema/0	involves: C57BL/6 * DBA/2	J:238692	View

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-SNCA*A53T)33Vle/0	involves: C3H/HeH * C57BL/6	J:174555	View

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-SNCA*E57K)16Ema/0	involves: C57BL/6 * DBA/2	J:236596	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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