obesity Disease Ontology Browser

Disease Ontology Browser

obesity (DOID:9970)
Alliance: disease page
Alt IDs: OMIM:601665, EFO:0001073, ICD10CM:E66.9, ICD9CM:278.00, MESH:D009765, NCI:C159658, UMLS_CUI:C0028754
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.

Term Browser
Genes (131)
Models (70)

Disease References using Mouse Models (85)

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Ar

Allelic Composition	Genetic Background	Reference	Phenotypes
Artm1Ska/Y Tg(CMV-cre)1Ipc/?	involves: C57BL/6 * CBA	J:85484	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Bbs4

Allelic Composition	Genetic Background	Reference	Phenotypes
Bbs4Gt1Nk/Bbs4Gt1Nk	involves: 129S7/SvEvBrd * C57BL/6J	J:92950	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Cpe

Allelic Composition	Genetic Background	Reference	Phenotypes
Cpefat/Cpefat	BKSChpLt.HRS-Cpe^fat/J	J:10872	View
Cpefat/Cpefat	involves: HRS/J	J:13651, J:10872	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Lepr

Allelic Composition	Genetic Background	Reference	Phenotypes
Leprtm1Mgmj/Leprtm1Mgmj	B6.129-Lepr^tm1Mgmj	J:82334	View
Leprdb-Pas/Leprdb-Pas	involves: DW/Pas	J:31095	View
Leprtm1Chua/Leprtm1Chua	involves: 129 * C57BL/6	J:94019	View
Leprtm1.1Chua/Leprtm1.1Chua	involves: 129 * C57BL/6	J:94019	View
Leprtm1.2Chua/Leprtm1.2Chua	involves: 129 * C57BL/6	J:94019	View
Leprdb-3J/Leprdb-3J	129P3/J-Lepr^db-3J/J	J:6337	View
LeprDb-Btlr/LeprDb-Btlr	C57BL/6J-Lepr^Db-Btlr	J:133632	View
LeprDb-2Btlr/LeprDb-2Btlr	C57BL/6J-Lepr^Db-2Btlr	J:133633	View
Leprm3Btlr/Leprm3Btlr	C57BL/6J-Lepr^m3Btlr	J:140985	View
Leprtm1Yli/Leprtm1Yli	B6.129-Lepr^tm1Yli	J:142218	View
Leprtm2Yli/Leprtm2Yli	B6.129-Lepr^tm2Yli	J:142218	View
Leprbrta/Leprbrta	C57BL/6JSfdAnu-Lepr^brta/Anu	J:104190	View
Leprdb-Nokl/Leprdb-Nokl	C57BL/6N-Lepr^db-Nokl	J:313303	View
Leprdb/Leprdb Tg(SHBG)4-aGlha/0	involves: C57BL/6 * C57BLKS/J * CBA	J:232827	View
Leprtm1.2Chua/Leprtm1.2Chua	involves: 129 * C57BL/6J * FVB/N	J:106354	View
Leprdb/Leprdb	B6.Cg-Dock7^m +/+ Lepr^db/J	J:18161, J:82234, J:103063	View
Leprdb/Leprdb	B6NTac.BKS(D)-Lepr^db	J:313303	View
Leprdb/Leprdb	BKS.Cg-Dock7^m +/+ Lepr^db/J	J:6323	View
Leprdb/Leprdb	FVB.BKS-Lepr^db	J:78850	View
Leprdb/Leprdb	involves: C57BLKS/J	J:96047, J:104790, J:106871	View
Leprdb/Leprdb-Nokl	B6NTac.Cg-Lepr^db Lepr^db-Nokl	J:313303	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Mc3r

Allelic Composition	Genetic Background	Reference	Phenotypes
Mc3rtm1Cone/Mc3rtm1Cone	involves: 129S4/SvJae * C57BL/6J	J:78132	View
Mc3rtm1Cone/Mc3r+	involves: 129S4/SvJae * C57BL/6J	J:78132	View
Mc3rtm1Lvp/Mc3rtm1Lvp Mc4rtm1Dhu/Mc4rtm1Dhu	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	J:64365	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Mc4r

Allelic Composition	Genetic Background	Reference	Phenotypes
Mc4rtm1Dhu/Mc4rtm1Dhu	involves: 129S4/SvJae * C57BL/6J	J:38224	View
Mc3rtm1Lvp/Mc3rtm1Lvp Mc4rtm1Dhu/Mc4rtm1Dhu	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	J:64365	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Mkks

Allelic Composition	Genetic Background	Reference	Phenotypes
Mkkstm1Vcs/Mkkstm1Vcs	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	J:99276	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Pcsk1

Allelic Composition	Genetic Background	Reference	Phenotypes
Pcsk1N222D/Pcsk1N222D	C57BL/6-Pcsk1^N222D	J:109531	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Pomc

Allelic Composition	Genetic Background	Reference	Phenotypes
Pomctm1Sora/Pomctm1Sora	involves: 129S2/SvHsd * 129S6/SvEvTac	J:89244	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Sim1

Allelic Composition	Genetic Background	Reference	Phenotypes
Sim1tm1Fan/Sim1+ Sim2tm1Fan/Sim2+	involves: 129/Sv * C57BL/6	J:76787	View
Sim1tm1Fan/Sim1+	involves: 129/Sv * C57BL/6	J:70586	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: a

Allelic Composition	Genetic Background	Reference	Phenotypes
Aiy/Aiy	C3H/HeJ-A^iy	J:30922	View
Aiy/A	C3H/HeJ-A^iy	J:30922	View
Ay/A	involves: C57BL/6	J:131039	View
Avy/a	involves: C3H/HeJ * C57BL/6	J:13142, J:117156	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Alms1

Allelic Composition	Genetic Background	Reference	Phenotypes
Alms1Gt(XH152)Byg/Alms1Gt(XH152)Byg	involves: 129P2/OlaHsd * C57BL/6J	J:100403	View
Alms1bbb/Alms1bbb	C57BL/6JSfdAnu-Alms1^bbb/Anu	J:104190	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Angptl6

Allelic Composition	Genetic Background	Reference	Phenotypes
Angptl6tm1Yo/Angptl6tm1Yo	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:97552	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Ankrd26

Allelic Composition	Genetic Background	Reference	Phenotypes
Ankrd26Gt(XK525)Byg/Ankrd26Gt(XK525)Byg	involves: 129P2/OlaHsd * C57BL/6	J:130984	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Bbs1

Allelic Composition	Genetic Background	Reference	Phenotypes
Bbs1Gt1Nk/Bbs1Gt1Nk	involves: 129S7/SvEvBrd * C57BL/6J	J:92950	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Gpr12

Allelic Composition	Genetic Background	Reference	Phenotypes
Gpr12tm1Dgen/Gpr12tm1Dgen	B6.129P2-Gpr12^tm1Dgen	J:111942	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Gucy2c

Allelic Composition	Genetic Background	Reference	Phenotypes
Gucy2ctm1Gar/Gucy2ctm1Gar	B6.129S6-Gucy2c^tm1Gar	J:178241	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Hlb228

Allelic Composition	Genetic Background	Reference	Phenotypes
Hlb228/?	involves: 129 * C57BL/6	J:82961	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Kdm3a

Allelic Composition	Genetic Background	Reference	Phenotypes
Kdm3atm1.1Yzha/Kdm3atm1.1Yzha	B6.129P2-Kdm3a^tm1.1Yzha	J:147295	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Lep

Allelic Composition	Genetic Background	Reference	Phenotypes
Lepm1Btlr/Lepm1Btlr	C57BL/6J-Lep^m1Btlr	J:189953	View
Lepob/Lepob	B6.Cg-Lep^ob/J	J:103063, J:104171	View
Lepob/Lepob	D2.Cg-Lep^ob/Chua	J:78850	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Ncoa1

Allelic Composition	Genetic Background	Reference	Phenotypes
Ncoa1tm1.1Hkaw/Ncoa1tm1.1Hkaw	B6.Cg-Ncoa1^tm1.1Hkaw	J:111490	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Neil1

Allelic Composition	Genetic Background	Reference	Phenotypes
Neil1tm1Rsld/Neil1+	either: B6.129S1-Neil1^tm1Rsld or (involves: 129S1/Sv * C57BL/6)	J:106077	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Nmf15

Allelic Composition	Genetic Background	Reference	Phenotypes
Nmf15/Nmf15+	C57BL/6J-Nmf15/J	J:82238	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Npy1r

Allelic Composition	Genetic Background	Reference	Phenotypes
Npy1rtm1Tped/Npy1rtm1Tped	B6.129P2-Npy1r^tm1Tped	J:87424	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Plscr3

Allelic Composition	Genetic Background	Reference	Phenotypes
Plscr3tm1Sims/Plscr3tm1Sims	involves: 129S/SvEvBrd * C57BL/6J	J:92404	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Prkci

Allelic Composition	Genetic Background	Reference	Phenotypes
Prkcitm1Rfar/Prkci+ Tg(Ckmm-cre)5Khn/?	involves: 129P2/OlaHsd * C57BL/6 * FVB	J:123964	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Prlh

Allelic Composition	Genetic Background	Reference	Phenotypes
Prlhtm1Taon/Prlhtm1Taon	B6N.129X1-Prlh^tm1Taon	J:144729	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Prox1

Allelic Composition	Genetic Background	Reference	Phenotypes
Prox1tm1Gco/Prox1+	involves: 129S1/Sv * 129X1/SvJ * NMRI	J:102652	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Rsc1a1

Allelic Composition	Genetic Background	Reference	Phenotypes
Rsc1a1tm1Koep/Rsc1a1tm1Koep	B6.129-Rsc1a1^tm1Koep	J:95148	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Snap25

Allelic Composition	Genetic Background	Reference	Phenotypes
Snap25tm1.1Bark/Snap25tm1.1Bark	Not Specified	J:226064	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Tub

Allelic Composition	Genetic Background	Reference	Phenotypes
Tubtub/Tubtub	B6(AU)-Tub^tub/J	J:32415	View
Tubtub/Tubtub	C57BL/6J-Tub^tub	J:13772	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Gene: Tyk2

Allelic Composition	Genetic Background	Reference	Phenotypes
Tyk2tm1Shmd/Tyk2tm1Shmd	either: (involves: 129 * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	J:195099	View

Mouse Models

Human Disease Modeled: obesity

Allelic Composition	Genetic Background	Reference	Phenotypes
Adrb1tm1Bkk/Adrb1tm1Bkk Adrb2tm1Bkk/Adrb2tm1Bkk Adrb3tm1Lowl/Adrb3tm1Lowl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N	J:79309	View

Mouse Models

Human Disease Modeled: obesity

Allelic Composition	Genetic Background	Reference	Phenotypes
Adrb1tm1Bkk/Adrb1tm1Bkk Adrb2tm1Bkk/Adrb2tm1Bkk Adrb3tm1Lowl/Adrb3tm1Lowl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N	J:79309	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Transgene: Tg(Crh)227.1Pbl

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Crh)227.1Pbl/0	involves: C57BL/6 * SJL	J:92996	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Transgene: Tg(Fabp4-Phb)#Smis

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Fabp4-Phb)#Smis/0	involves: CD-1	J:230172	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Transgene: Tg(Fabp4-Phb*Y114F)#Smis

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Fabp4-Phb*Y114F)#Smis/0	Not Specified	J:227976	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Transgene: Tg(RP11-578M14)5Mkru

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(RP11-578M14)5Mkru/0	involves: FVB/N	J:256501	View

Mouse Models

Human Disease Modeled: obesity
Associated Mouse Other Genome Feature: Timo

Allelic Composition	Genetic Background	Reference	Phenotypes
Timo/Timo	either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ)	J:127183	View
Timo/Timo+	either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ)	J:127183	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24