| Disease Term | Human Homologs | Mouse Homologs | Mouse Models | Homology Source | |||
  | essential thrombocythemia | JAK2* | Jak2* | 2 models | Alliance of Genome Resources | ||
| juvenile myelomonocytic leukemia | NF1* | Nf1* | 2 models | Alliance of Genome Resources | |||
| juvenile myelomonocytic leukemia | PTPN11* | Ptpn11* | 1 model | Alliance of Genome Resources | |||
| myelofibrosis | JAK2* | Jak2* | 2 models | Alliance of Genome Resources | |||
| myeloproliferative neoplasm | PDGFRB* | Pdgfrb* | 1 model | Alliance of Genome Resources | |||
| polycythemia vera | JAK2* | Jak2* | 6 models | Alliance of Genome Resources | |||
| | essential thrombocythemia | MYB | Myb* | 1 model | Alliance of Genome Resources | ||
| juvenile myelomonocytic leukemia | FLT3 | Flt3* | 2 models | Alliance of Genome Resources | |||
| juvenile myelomonocytic leukemia | KRAS | Kras* | 3 models | Alliance of Genome Resources | |||
| multiple myeloma | MAF | Maf* | 2 models | Alliance of Genome Resources | |||
| myelodysplastic/myeloproliferative neoplasm | DIDO1 | Dido1* | 1 model | Alliance of Genome Resources | |||
| myelofibrosis | NCOR2 | Ncor2* | 1 model | Alliance of Genome Resources | |||
| myelofibrosis | MYB | Myb* | 1 model | Alliance of Genome Resources | |||
| myelofibrosis | GATA1 | Gata1* | 2 models | Alliance of Genome Resources | |||
| myeloproliferative neoplasm | JAK2 | Jak2* | 1 model | Alliance of Genome Resources | |||
| myeloproliferative neoplasm | ASXL1 | Asxl1* | 1 model | Alliance of Genome Resources | |||
| | atypical chronic myeloid leukemia, BCR-ABL1 negative | FGFR1* | Fgfr1 | Alliance of Genome Resources | |||
| essential thrombocythemia | SH2B3* | Sh2b3 | Alliance of Genome Resources | ||||
| essential thrombocythemia | MPL* | Mpl | Alliance of Genome Resources | ||||
| essential thrombocythemia | CALR* | Calr | Alliance of Genome Resources | ||||
| essential thrombocythemia | THPO* | Thpo | Alliance of Genome Resources | ||||
| essential thrombocythemia | VWF* | Vwf | Alliance of Genome Resources | ||||
| juvenile myelomonocytic leukemia | CBL* | Cbl | Alliance of Genome Resources | ||||
| juvenile myelomonocytic leukemia | JAK3* | Jak3 | Alliance of Genome Resources | ||||
| juvenile myelomonocytic leukemia | AKAP12* | Akap12 | Alliance of Genome Resources | ||||
| juvenile myelomonocytic leukemia | ARHGAP26* | Arhgap26 | Alliance of Genome Resources | ||||
| juvenile myelomonocytic leukemia | CSF2* | Csf2 | Alliance of Genome Resources | ||||
| multiple myeloma | SOD2* | Sod2 | Alliance of Genome Resources | ||||
| multiple myeloma | KRAS* | Kras | Alliance of Genome Resources | ||||
| multiple myeloma | LIG4* | Lig4 | Alliance of Genome Resources | ||||
| multiple myeloma | MEFV* | Mefv | Alliance of Genome Resources | ||||
| multiple myeloma | MET* | Met | Alliance of Genome Resources | ||||
| multiple myeloma | MIR320A* | Mir320 | Alliance of Genome Resources | ||||
| multiple myeloma | MTHFR* | Mthfr | Alliance of Genome Resources | ||||
| multiple myeloma | MTR* | Mtr | Alliance of Genome Resources | ||||
| multiple myeloma | MTRR* | Mtrr | Alliance of Genome Resources | ||||
| multiple myeloma | NFKBIA* | Nfkbia | Alliance of Genome Resources | ||||
| multiple myeloma | NQO1* | Nqo1 | Alliance of Genome Resources | ||||
| multiple myeloma | NRAS* | Nras | Alliance of Genome Resources | ||||
| multiple myeloma | PF4*, PF4V1 | Pf4 | Alliance of Genome Resources | ||||
| multiple myeloma | POLR1G* | Polr1g | Alliance of Genome Resources | ||||
| multiple myeloma | PON1* | Pon1 | Alliance of Genome Resources | ||||
| multiple myeloma | RBP1* | Rbp1 | Alliance of Genome Resources | ||||
| multiple myeloma | ROBO1* | Robo1 | Alliance of Genome Resources | ||||
| multiple myeloma | SPARC* | Sparc | Alliance of Genome Resources | ||||
| multiple myeloma | SPP1* | Spp1 | Alliance of Genome Resources | ||||
| multiple myeloma | TFRC* | Tfrc | Alliance of Genome Resources | ||||
| multiple myeloma | TGFB1* | Tgfb1 | Alliance of Genome Resources | ||||
| multiple myeloma | TNF* | Tnf | Alliance of Genome Resources | ||||
| multiple myeloma | TNFRSF10A*, TNFRSF10B, TNFRSF10C, TNFRSF10D | Tnfrsf10b | Alliance of Genome Resources | ||||
| multiple myeloma | TNFRSF17* | Tnfrsf17 | Alliance of Genome Resources | ||||
| multiple myeloma | TP53* | Trp53 | Alliance of Genome Resources | ||||
| multiple myeloma | TYMS* | Tyms | Alliance of Genome Resources | ||||
| multiple myeloma | VEGFA* | Vegfa | Alliance of Genome Resources | ||||
| multiple myeloma | XPO5* | Xpo5 | Alliance of Genome Resources | ||||
| multiple myeloma | XRCC3* | Xrcc3 | Alliance of Genome Resources | ||||
| multiple myeloma | XRCC4* | Xrcc4 | Alliance of Genome Resources | ||||
| multiple myeloma | XRCC5* | Xrcc5 | Alliance of Genome Resources | ||||
| multiple myeloma | ABCG2* | Abcg2, Abcg3 | Alliance of Genome Resources | ||||
| multiple myeloma | ACE* | Ace | Alliance of Genome Resources | ||||
| multiple myeloma | APOE* | Apoe | Alliance of Genome Resources | ||||
| multiple myeloma | BCL2L10* | Bcl2l10 | Alliance of Genome Resources | ||||
| multiple myeloma | CBX7* | Cbx7 | Alliance of Genome Resources | ||||
| multiple myeloma | CCND1* | Ccnd1 | Alliance of Genome Resources | ||||
| multiple myeloma | CD40* | Cd40 | Alliance of Genome Resources | ||||
| multiple myeloma | CD40LG* | Cd40lg | Alliance of Genome Resources | ||||
| multiple myeloma | CDKN2A* | Cdkn2a | Alliance of Genome Resources | ||||
| multiple myeloma | CFHR1*, CFHR2 | Cfhr1 | Alliance of Genome Resources | ||||
| multiple myeloma | CTLA4* | Ctla4 | Alliance of Genome Resources | ||||
| multiple myeloma | CYP1A1* | Cyp1a1 | Alliance of Genome Resources | ||||
| multiple myeloma | CYP2C19*, CYP2C8, CYP2C9, CYP2C18 | Cyp2c29, Cyp2c37, Cyp2c38, Cyp2c39, Cyp2c50, Cyp2c55, Cyp2c65, Cyp2c66 | Alliance of Genome Resources | ||||
| multiple myeloma | EPHX1* | Ephx1 | Alliance of Genome Resources | ||||
| multiple myeloma | ERCC1* | Ercc1 | Alliance of Genome Resources | ||||
| multiple myeloma | ERCC2* | Ercc2 | Alliance of Genome Resources | ||||
| multiple myeloma | FCGR2A*, FCGR2B, FCGR2C | Fcgr2b, Fcgr3 | Alliance of Genome Resources | ||||
| multiple myeloma | FGG* | Fgg | Alliance of Genome Resources | ||||
| multiple myeloma | GPX1* | Gpx1 | Alliance of Genome Resources | ||||
| multiple myeloma | GPX3* | Gpx3 | Alliance of Genome Resources | ||||
| multiple myeloma | GSTM1*, GSTM5 | Gstm1, Gstm2, Gstm3, Gstm6 | Alliance of Genome Resources | ||||
| multiple myeloma | GSTP1* | Gstp1, Gstp2, Gstp3, Gstp-ps | Alliance of Genome Resources | ||||
| multiple myeloma | GSTT1* | Gstt1 | Alliance of Genome Resources | ||||
| multiple myeloma | HFE* | Hfe | Alliance of Genome Resources | ||||
| multiple myeloma | HK1* | Hk1 | Alliance of Genome Resources | ||||
| multiple myeloma | ICAM1* | Icam1 | Alliance of Genome Resources | ||||
| multiple myeloma | IL1A* | Il1a | Alliance of Genome Resources | ||||
| multiple myeloma | IL1B* | Il1b | Alliance of Genome Resources | ||||
| multiple myeloma | IL1RN* | Il1rn | Alliance of Genome Resources | ||||
| multiple myeloma | IL4R* | Il4ra | Alliance of Genome Resources | ||||
| multiple myeloma | IL10* | Il10 | Alliance of Genome Resources | ||||
| multiple myeloma | IRF4* | Irf4 | Alliance of Genome Resources | ||||
| multiple myeloma | IRF8* | Irf8 | Alliance of Genome Resources | ||||
| myelofibrosis | EZH2* | Ezh2 | Alliance of Genome Resources | ||||
| myelofibrosis | ASXL1* | Asxl1 | Alliance of Genome Resources | ||||
| myelofibrosis | CALR* | Calr | Alliance of Genome Resources | ||||
| myelofibrosis | HFE* | Hfe | Alliance of Genome Resources | ||||
| myelofibrosis | KMT2A* | Kmt2a | Alliance of Genome Resources | ||||
| myelofibrosis | MPL* | Mpl | Alliance of Genome Resources | ||||
| myelofibrosis | SH2B3* | Sh2b3 | Alliance of Genome Resources | ||||
| myeloid neoplasm | MTHFR* | Mthfr | Alliance of Genome Resources | ||||
| myeloid neoplasm | JAK2* | Jak2 | Alliance of Genome Resources | ||||
| myeloid neoplasm | ETV6* | Etv6 | Alliance of Genome Resources | ||||
| myeloid neoplasm | FGFR1* | Fgfr1 | Alliance of Genome Resources | ||||
| myeloid neoplasm | GPX1* | Gpx1 | Alliance of Genome Resources | ||||
| myeloid neoplasm | CBL* | Cbl | Alliance of Genome Resources | ||||
| myeloid neoplasm | MECOM* | Mecom | Alliance of Genome Resources | ||||
| myeloproliferative disorder with eosinophilia | PDGFRB* | Pdgfrb | Alliance of Genome Resources | ||||
| myeloproliferative neoplasm | DDX41* | Ddx41 | Alliance of Genome Resources | ||||
| myeloproliferative neoplasm | TET2* | Tet2 | Alliance of Genome Resources | ||||
| myeloproliferative neoplasm | ETV6* | Etv6 | Alliance of Genome Resources | ||||
| polycythemia vera | HFE* | Hfe | Alliance of Genome Resources | ||||
| polycythemia vera | GSTM1*, GSTM5 | Gstm1, Gstm2, Gstm3, Gstm6 | Alliance of Genome Resources | ||||
| transient myeloproliferative syndrome | GATA1* | Gata1 | 2 models | Alliance of Genome Resources | |||
Excel File
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Transgenes and other genome features developed in mice to model this disease.
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| Disease Term | Transgenes and Other Genome Features | Mouse Models | |
| essential thrombocythemia | Tg(Vav1-JAK2*V617F)AZjz | 1 model | |
| essential thrombocythemia | Tg(JAK2*V617F)FF1Rsko | 1 model | |
| multiple myeloma | Tg(Cd4-NPM/ALK)N1Ingh | 1 model | |
| multiple myeloma | Tg(Igh-Maf)68Staka | 1 model | |
| multiple myeloma | Tg(Igh-Maf)524Staka | 1 model | |
| multiple myeloma | Tg(Igkv3-5*-MYC)24Plbe | 1 model | |
| myelofibrosis | Tg(H2-Kb-Jak2*V617F)2Shmd | 1 model | |
| myelofibrosis | Tg(Vav1-JAK2*V617F)AZjz | 1 model | |
| myeloproliferative neoplasm | Tg(Vav1-Asxl1*Y588X)#Fcy | 1 model | |
| polycythemia vera | Tg(Vav1-JAK2*V617F)AZjz | 1 model | |
| polycythemia vera | Tg(JAK2*V617F)FF1Rsko | 1 model | |