| Disease Term | Human Homologs | Mouse Homologs | Mouse Models | Homology Source | |||
  | cardiofaciocutaneous syndrome | BRAF* | Braf* | 6 models | Alliance of Genome Resources | ||
| Costello syndrome | HRAS* | Hras* | 2 models | Alliance of Genome Resources | |||
| neurofibromatosis 1 | NF1* | Nf1* | 17 models | Alliance of Genome Resources | |||
| Noonan syndrome 1 | PTPN11* | Ptpn11* | 3 models | Alliance of Genome Resources | |||
| Noonan syndrome 10 | LZTR1* | Lztr1* | 1 model | Alliance of Genome Resources | |||
| Noonan syndrome 3 | KRAS* | Kras* | 1 model | Alliance of Genome Resources | |||
| Noonan syndrome 4 | SOS1* | Sos1* | 2 models | Alliance of Genome Resources | |||
| Noonan syndrome 5 | RAF1* | Raf1* | 2 models | Alliance of Genome Resources | |||
| Noonan syndrome 8 | RIT1* | Rit1* | 1 model | Alliance of Genome Resources | |||
| vestibular schwannomatosis | NF2* | Nf2* | 1 model | Alliance of Genome Resources | |||
| | cardiofaciocutaneous syndrome | MAP2K1 | Map2k1* | 1 model | Alliance of Genome Resources | ||
| Noonan syndrome | APAF1 | Apaf1* | 1 model | Alliance of Genome Resources | |||
| Noonan syndrome | KAT6B | Kat6b* | 1 model | Alliance of Genome Resources | |||
| Noonan syndrome with multiple lentigines | PTPN11 | Ptpn11* | 3 models | Alliance of Genome Resources | |||
| RASopathy | RREB1 | Rreb1* | 1 model | Alliance of Genome Resources | |||
| | cardiofaciocutaneous syndrome | KRAS* | Kras | Alliance of Genome Resources | |||
| cardiofaciocutaneous syndrome 1 | BRAF* | Braf | Alliance of Genome Resources | ||||
| cardiofaciocutaneous syndrome 2 | KRAS* | Kras | Alliance of Genome Resources | ||||
| cardiofaciocutaneous syndrome 3 | MAP2K1* | Map2k1 | Alliance of Genome Resources | ||||
| cardiofaciocutaneous syndrome 4 | MAP2K2* | Map2k2 | Alliance of Genome Resources | ||||
| Legius syndrome | SPRED1* | Spred1 | Alliance of Genome Resources | ||||
| neurofibromatosis-Noonan syndrome | NF1* | Nf1 | Alliance of Genome Resources | ||||
| Noonan syndrome | PTPN11* | Ptpn11 | Alliance of Genome Resources | ||||
| Noonan syndrome | KRAS* | Kras | Alliance of Genome Resources | ||||
| Noonan syndrome | LZTR1* | Lztr1 | Alliance of Genome Resources | ||||
| Noonan syndrome | RAF1* | Raf1 | Alliance of Genome Resources | ||||
| Noonan syndrome | SPRED2* | Spred2 | Alliance of Genome Resources | ||||
| Noonan syndrome | SOS1* | Sos1 | Alliance of Genome Resources | ||||
| Noonan syndrome | RIT1* | Rit1 | Alliance of Genome Resources | ||||
| Noonan syndrome | RASA2* | Rasa2 | Alliance of Genome Resources | ||||
| Noonan syndrome 11 | MRAS* | Mras | Alliance of Genome Resources | ||||
| Noonan syndrome 12 | RRAS2* | Rras2 | Alliance of Genome Resources | ||||
| Noonan syndrome 13 | MAPK1* | Mapk1 | Alliance of Genome Resources | ||||
| Noonan syndrome 2 | LZTR1* | Lztr1 | Alliance of Genome Resources | ||||
| Noonan syndrome 6 | NRAS* | Nras | Alliance of Genome Resources | ||||
| Noonan syndrome 7 | BRAF* | Braf | Alliance of Genome Resources | ||||
| Noonan syndrome 9 | SOS2* | Sos2 | Alliance of Genome Resources | ||||
| Noonan syndrome-like disorder with loose anagen hair 1 | SHOC2* | Shoc2 | Alliance of Genome Resources | ||||
| Noonan syndrome-like disorder with loose anagen hair 2 | PPP1CB* | Ppp1cb | Alliance of Genome Resources | ||||
| Noonan syndrome with multiple lentigines 1 | PTPN11* | Ptpn11 | Alliance of Genome Resources | ||||
| Noonan syndrome with multiple lentigines 2 | RAF1* | Raf1 | Alliance of Genome Resources | ||||
| Noonan syndrome with multiple lentigines 3 | BRAF* | Braf | Alliance of Genome Resources | ||||
| RASopathy | RIT1* | Rit1 | Alliance of Genome Resources | ||||
| schwannomatosis | LZTR1* | Lztr1 | Alliance of Genome Resources | ||||
| schwannomatosis | SMARCB1* | Smarcb1 | Alliance of Genome Resources | ||||
| schwannomatosis 1 | SMARCB1* | Smarcb1 | Alliance of Genome Resources | ||||
| schwannomatosis 2 | LZTR1* | Lztr1 | Alliance of Genome Resources | ||||
| spinal neurofibromatosis | NF1* | Nf1 | Alliance of Genome Resources | ||||
| vestibular schwannomatosis | SMARCB1* | Smarcb1 | Alliance of Genome Resources | ||||
| vestibular schwannomatosis | VEGFA* | Vegfa | Alliance of Genome Resources | ||||
| Watson syndrome | NF1* | Nf1 | Alliance of Genome Resources | ||||
Excel File
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Transgenes and other genome features developed in mice to model this disease.
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| Disease Term | Transgenes and Other Genome Features | Mouse Models | |
| Noonan syndrome 1 | Tg(CAG-cat,-Ptpn11*Q97R)1Rbns | 2 models | |
| Noonan syndrome 1 | Tg(Myh7-Ptpn11*Q79R)11Rbns | 1 model | |
| Noonan syndrome with multiple lentigines | Tg(Myh7-Ptpn11*Q510E)#Krnz | 1 model | |
| Noonan syndrome with multiple lentigines | Tg(CAG-cat,-Ptpn11*Q510E)#Krnz | 1 model | |