| Disease Term | Human Homologs | Mouse Homologs | Mouse Models | Homology Source | |||
 | acute lymphoblastic leukemia | EZH2 | Ezh2* | 2 models | Alliance of Genome Resources | ||
| acute lymphoblastic leukemia | KMT2A | Kmt2a* | 1 model | Alliance of Genome Resources | |||
| acute lymphoblastic leukemia | LMO2 | Lmo2* | 1 model | Alliance of Genome Resources | |||
| acute lymphoblastic leukemia | NOTCH3 | Notch3* | 1 model | Alliance of Genome Resources | |||
| acute lymphoblastic leukemia | PTEN | Pten* | 1 model | Alliance of Genome Resources | |||
| lymphoid leukemia | TAL1 | Tal1* | 1 model | Alliance of Genome Resources | |||
| T-cell acute lymphoblastic leukemia | HMGA1 | Hmga1*, Hmga1b | 1 model | Alliance of Genome Resources | |||
| T-cell acute lymphoblastic leukemia | NBN | Nbn* | 1 model | Alliance of Genome Resources | |||
| T-cell adult acute lymphocytic leukemia | ZEB2 | Zeb2* | 2 models | Alliance of Genome Resources | |||
| T-cell adult acute lymphocytic leukemia | CNTN2 | Cntn2* | 1 model | Alliance of Genome Resources | |||
 | acute biphenotypic leukemia | DOT1L* | Dot1l | Alliance of Genome Resources | |||
| acute lymphoblastic leukemia | CREBBP* | Crebbp | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | CSF3* | Csf3 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | CYP1A1* | Cyp1a1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | CYP2D6*, CYP2D7 | Cyp2d9, Cyp2d10, Cyp2d11, Cyp2d12, Cyp2d22, Cyp2d26, Cyp2d34, Cyp2d40 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | CYP3A5*, CYP3A4, CYP3A7, CYP3A7-CYP3A51P, CYP3A43 | Cyp3a11, Cyp3a13, Cyp3a16, Cyp3a25, Cyp3a41a, Cyp3a41b, Cyp3a44, Cyp3a57, Cyp3a59 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | DHFR*, DHFR2, DHFRP1 | Dhfr | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | DNMT3A* | Dnmt3a | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | DPYD* | Dpyd | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | EPHX1* | Ephx1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | ERCC1* | Ercc1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | ERCC2* | Ercc2 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | FLT3* | Flt3 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | GH1*, CSH1, CSH2, CSHL1, GH2 | Gh | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | GNB1* | Gnb1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | GPX1* | Gpx1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | GSTM1*, GSTM5 | Gstm1, Gstm2, Gstm3, Gstm6 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | GSTP1* | Gstp1, Gstp2, Gstp3, Gstp-ps | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | GSTT1* | Gstt1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | H1-2* | H1f2 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | HLA-DQA1*, HLA-DQA2 | H2-Aa | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | HLA-DQB1*, HLA-DQB2 | H2-Ab1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | HFE* | Hfe | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | HK1* | Hk1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | IFNG* | Ifng | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | IKZF1* | Ikzf1 | 1 model | Alliance of Genome Resources | |||
| acute lymphoblastic leukemia | IRF4* | Irf4 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | ITPA* | Itpa | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | KDM6A* | Kdm6a | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | KRAS* | Kras | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | MEFV* | Mefv | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | MTHFR* | Mthfr | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | MTR* | Mtr | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | MTRR* | Mtrr | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | NAT2*, NAT1 | Nat1, Nat2, Nat3 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | NBN* | Nbn | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | NOS3* | Nos3 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | NQO1* | Nqo1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | NRAS* | Nras | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | NUP214* | Nup214 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | PAX5* | Pax5 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | PON1* | Pon1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | TAL1* | Tal1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | TAL2* | Tal2 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | TERT* | Tert | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | TPMT* | Tpmt | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | TTC12* | Ttc12 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | TYMS* | Tyms | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | XRCC1* | Xrcc1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | ABCB1* | Abcb1a, Abcb1b | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | ABCC2* | Abcc2 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | ABO* | Abo | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | BAX* | Bax | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | BCL2L1* | Bcl2l1 | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | BCR* | Bcr | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | CDKN2A* | Cdkn2a | Alliance of Genome Resources | ||||
| acute lymphoblastic leukemia | CFB* | Cfb | Alliance of Genome Resources | ||||
| adult T-cell leukemia/lymphoma | TLX1* | Tlx1 | Alliance of Genome Resources | ||||
| adult T-cell leukemia/lymphoma | TAL2* | Tal2 | Alliance of Genome Resources | ||||
| adult T-cell leukemia/lymphoma | FAS* | Fas | Alliance of Genome Resources | ||||
| adult T-cell leukemia/lymphoma | JAK3* | Jak3 | Alliance of Genome Resources | ||||
| adult T-cell leukemia/lymphoma | NOTCH1* | Notch1 | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | TFPI* | Tfpi | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | IKZF1* | Ikzf1 | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | CYP3A5*, CYP3A4, CYP3A7, CYP3A7-CYP3A51P, CYP3A43 | Cyp3a11, Cyp3a13, Cyp3a16, Cyp3a25, Cyp3a41a, Cyp3a41b, Cyp3a44, Cyp3a57, Cyp3a59 | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | CDKN2A* | Cdkn2a | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | AKR1C3*, AKR1C1, AKR1C2, AKR1C4 | Akr1c6, Akr1c12, Akr1c13, Akr1c14, Akr1c18, Akr1c19, Akr1c20, Akr1c21, Akr1cl | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | BRD2* | Brd2 | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | ABL1* | Abl1 | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | F3* | F3 | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | TP53* | Trp53 | Alliance of Genome Resources | ||||
| B-lymphoblastic leukemia/lymphoma | TNFSF13* | Tnfsf13 | Alliance of Genome Resources | ||||
| chronic lymphocytic leukemia | CD79B* | Cd79b | Alliance of Genome Resources | ||||
| chronic lymphocytic leukemia | CD86* | Cd86 | Alliance of Genome Resources | ||||
| chronic lymphocytic leukemia | IRF4* | Irf4 | Alliance of Genome Resources | ||||
| chronic lymphocytic leukemia | PON1* | Pon1 | Alliance of Genome Resources | ||||
| chronic lymphocytic leukemia | PTPN22* | Ptpn22 | Alliance of Genome Resources | ||||
| hairy cell leukemia | GPX1* | Gpx1 | Alliance of Genome Resources | ||||
| lymphoid leukemia | ETV6* | Etv6 | Alliance of Genome Resources | ||||
| lymphoid leukemia | FCGR2A*, FCGR2B*, FCGR2C | Fcgr2b, Fcgr3 | Alliance of Genome Resources | ||||
| lymphoid leukemia | BCL2L1* | Bcl2l1 | Alliance of Genome Resources | ||||
| lymphoid leukemia | GSTT1* | Gstt1 | Alliance of Genome Resources | ||||
| lymphoid leukemia | GSTP1* | Gstp1, Gstp2, Gstp3, Gstp-ps | Alliance of Genome Resources | ||||
| lymphoid leukemia | GSTM1*, GSTM5 | Gstm1, Gstm2, Gstm3, Gstm6 | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | PDGFRA* | Pdgfra | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | RPL5* | Rpl5 | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | RPL11* | Rpl11 | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | AKR1C3*, AKR1C1, AKR1C2, AKR1C4 | Akr1c6, Akr1c12, Akr1c13, Akr1c14, Akr1c18, Akr1c19, Akr1c20, Akr1c21, Akr1cl | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | LYL1* | Lyl1 | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | JAK3* | Jak3 | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | JAK1* | Jak1 | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | DNMT3A* | Dnmt3a | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | CXCR4* | Cxcr4 | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | CDKN2A* | Cdkn2a | Alliance of Genome Resources | ||||
| T-cell acute lymphoblastic leukemia | NUP98* | Nup98 | Alliance of Genome Resources | ||||
| T-cell prolymphocytic leukemia | JAK3* | Jak3 | Alliance of Genome Resources | ||||
Excel File
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Transgenes and other genome features developed in mice to model this disease.
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| Disease Term | Transgenes and Other Genome Features | Mouse Models | |
| acute leukemia | Tg(Ly6a-SET/NUP214)2969Gcg | 1 model | |
| acute lymphoblastic leukemia | Tg(CD2-Lmo2)#Thr | 1 model | |
| acute lymphoblastic leukemia | Tg(Igh-HMGA2)#Cro | 1 model | |
| acute lymphoblastic leukemia | Tg(Lck-Notch3)#Issc | 1 model | |
| chronic lymphocytic leukemia | Del(14Trim13-Rnaseh2b)6Rdf | 2 models | |
| chronic lymphocytic leukemia | Del(14Trim13-Dleu2)4Rdf | 2 models | |
| chronic lymphocytic leukemia | Mirc30 | 6 models | |
| chronic lymphocytic leukemia | Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro | 2 models | |
| chronic lymphocytic leukemia | Tg(Igh-ROR1)1Kip | 2 models | |
| chronic lymphocytic leukemia | Tg(Igh-TCL1A)1Ypek | 1 model | |
| chronic lymphocytic leukemia | Tg(Igh-V186.2-TCL1A)3Cro | 4 models | |
| chronic lymphocytic leukemia | Tg(Lck-TNFSF13)3919Mhah | 1 model | |
| lymphoid leukemia | Tg(Lck-Tal1)4709Led | 1 model | |
| T-cell acute lymphoblastic leukemia | Tg(H2-K-Hmga1)#Lmsr | 1 model | |
| T-cell adult acute lymphocytic leukemia | Tg(Lck-Tax)53Hall | 1 model | |