| Disease Term | Human Homologs | Mouse Homologs | Mouse Models | Homology Source | |||
  | osteoarthritis | GDF5* | Gdf5* | 1 model | Alliance of Genome Resources | ||
| osteoarthritis | MATN3* | Matn3* | 1 model | Alliance of Genome Resources | |||
| rheumatoid arthritis | TNF* | Tnf* | 6 models | Alliance of Genome Resources | |||
| | chronic recurrent multifocal osteomyelitis | PSTPIP2 | Pstpip2* | 1 model | Alliance of Genome Resources | ||
| osteoarthritis | ATP7A | Atp7a* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | BMP7 | Bmp7* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | BMPR1A | Bmpr1a* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | COL9A1 | Col9a1* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | COL11A1 | Col11a1* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | ENPP1 | Enpp1* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | ERG | Erg* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | ERRFI1 | Errfi1* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | MYL3 | Myl3* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | SMAD3 | Smad3* | 1 model | Alliance of Genome Resources | |||
| osteoarthritis | TGFBR1 | Tgfbr1* | 1 model | Alliance of Genome Resources | |||
| rheumatoid arthritis | ZFP36 | Zfp36* | 1 model | Alliance of Genome Resources | |||
| rheumatoid arthritis | ZAP70 | Zap70* | 1 model | Alliance of Genome Resources | |||
| rheumatoid arthritis | MMP14 | Mmp14* | 1 model | Alliance of Genome Resources | |||
| rheumatoid arthritis | DNASE2 | Dnase2a* | 2 models | Alliance of Genome Resources | |||
| rheumatoid arthritis | IL6ST | Il6st* | 1 model | Alliance of Genome Resources | |||
| | ankylosing spondylitis | IL23R* | Il23r | Alliance of Genome Resources | |||
| ankylosing spondylitis | IRAK1* | Irak1 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | JAK2* | Jak2 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | KDM5A* | Kdm5a | Alliance of Genome Resources | ||||
| ankylosing spondylitis | MTHFR* | Mthfr | Alliance of Genome Resources | ||||
| ankylosing spondylitis | PSMB9* | Psmb9 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | PTGER4* | Ptger4 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | TAP1* | Tap1 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | TAP2* | Tap2 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | TNFRSF1B* | Tnfrsf1b | Alliance of Genome Resources | ||||
| ankylosing spondylitis | ACE* | Ace | Alliance of Genome Resources | ||||
| ankylosing spondylitis | ANO6* | Ano6 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | ASPN* | Aspn | Alliance of Genome Resources | ||||
| ankylosing spondylitis | CYP1A1* | Cyp1a1 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | HLA-DQA1*, HLA-DQA2 | H2-Aa | Alliance of Genome Resources | ||||
| ankylosing spondylitis | HLA-DQB1*, HLA-DQB2 | H2-Ab1 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | HLA-B*, HLA-A, HLA-C, HLA-E, HLA-F, HLA-G, HLA-H | H2-D1, H2-K1, H2-L, H2-M1, H2-M2, H2-M3, H2-M5, H2-M9, H2-M10.1, H2-M10.2, H2-M10.3, H2-M10.4, H2-M10.5, H2-M10.6, H2-M11, H2-Q1, H2-Q2, H2-Q4, H2-Q6, H2-Q7, H2-Q8, H2-Q10, H2-T3, H2-T10, H2-T22, H2-T23 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | HLA-DRB1*, HLA-DRB3, HLA-DRB4, HLA-DRB5 | H2-Eb1, H2-Eb2 | Alliance of Genome Resources | ||||
| ankylosing spondylitis | IL17A* | Il17a | Alliance of Genome Resources | ||||
| arthritis | FCGR3A*, FCGR3B | Fcgr4 | Alliance of Genome Resources | ||||
| arthritis | IL23R* | Il23r | Alliance of Genome Resources | ||||
| arthritis | HLA-DQA1*, HLA-DQA2 | H2-Aa | Alliance of Genome Resources | ||||
| arthritis | GC* | Gc | Alliance of Genome Resources | ||||
| arthritis | CD40* | Cd40 | Alliance of Genome Resources | ||||
| arthritis | PARP1* | Parp1 | Alliance of Genome Resources | ||||
| arthritis | TLR4* | Tlr4 | Alliance of Genome Resources | ||||
| arthritis | B2M* | B2m | Alliance of Genome Resources | ||||
| arthritis | HLA-DQB1*, HLA-DQB2 | H2-Ab1 | Alliance of Genome Resources | ||||
| Beukes hip dysplasia | UFSP2* | Ufsp2 | Alliance of Genome Resources | ||||
| Caffey disease | COL1A1* | Col1a1 | Alliance of Genome Resources | ||||
| chondrocalcinosis | ANKH* | Ank | Alliance of Genome Resources | ||||
| chronic recurrent multifocal osteomyelitis | LPIN2* | Lpin2 | Alliance of Genome Resources | ||||
| chronic recurrent multifocal osteomyelitis | IL1R1* | Il1r1 | Alliance of Genome Resources | ||||
| chronic recurrent multifocal osteomyelitis | IL1RN* | Il1rn | Alliance of Genome Resources | ||||
| gout | HP*, HPR | Hp | Alliance of Genome Resources | ||||
| gout | ADRB3* | Adrb3 | Alliance of Genome Resources | ||||
| gout | ABCG2* | Abcg2, Abcg3 | Alliance of Genome Resources | ||||
| gout | SLC17A3* | Slc17a3 | Alliance of Genome Resources | ||||
| gout | A1CF* | A1cf | Alliance of Genome Resources | ||||
| gout | PRPS1* | Prps1 | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | PTPN22* | Ptpn22 | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | SH2D2A* | Sh2d2a | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | SLC11A1* | Slc11a1 | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | SLC26A2* | Slc26a2 | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | CCR5* | Ccr5 | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | CIITA* | Ciita | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | HLA-DQA1*, HLA-DQA2 | H2-Aa | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | GSTT1* | Gstt1 | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | HLA-DQB1*, HLA-DQB2 | H2-Ab1 | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | HLA-DRB1*, HLA-DRB3, HLA-DRB4, HLA-DRB5 | H2-Eb1, H2-Eb2 | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | HFE* | Hfe | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | IL1A* | Il1a | Alliance of Genome Resources | ||||
| juvenile rheumatoid arthritis | LACC1* | Lacc1 | Alliance of Genome Resources | ||||
| osteoarthritis | FCGR2A*, FCGR2B, FCGR2C | Fcgr2b, Fcgr3 | Alliance of Genome Resources | ||||
| osteoarthritis | ADAM12* | Adam12 | Alliance of Genome Resources | ||||
| osteoarthritis | ADAMTS5* | Adamts5 | Alliance of Genome Resources | ||||
| osteoarthritis | ADAMTS14* | Adamts14 | Alliance of Genome Resources | ||||
| osteoarthritis | ASPN* | Aspn | Alliance of Genome Resources | ||||
| osteoarthritis | BAG6* | Bag6 | Alliance of Genome Resources | ||||
| osteoarthritis | BGLAP* | Bglap, Bglap2, Bglap3 | Alliance of Genome Resources | ||||
| osteoarthritis | BMP2* | Bmp2 | Alliance of Genome Resources | ||||
| osteoarthritis | CD36* | Cd36 | Alliance of Genome Resources | ||||
| osteoarthritis | CILP* | Cilp | Alliance of Genome Resources | ||||
| osteoarthritis | CLEC3B* | Clec3b | Alliance of Genome Resources | ||||
| osteoarthritis | COL2A1* | Col2a1 | Alliance of Genome Resources | ||||
| osteoarthritis | DDR2* | Ddr2 | Alliance of Genome Resources | ||||
| osteoarthritis | ESR1* | Esr1 | Alliance of Genome Resources | ||||
| osteoarthritis | ESR2* | Esr2 | Alliance of Genome Resources | ||||
| osteoarthritis | FGFR1* | Fgfr1 | Alliance of Genome Resources | ||||
| osteoarthritis | FRZB* | Frzb | Alliance of Genome Resources | ||||
| osteoarthritis | GHR* | Ghr | Alliance of Genome Resources | ||||
| osteoarthritis | HFE* | Hfe | Alliance of Genome Resources | ||||
| osteoarthritis | MMP3* | Mmp3 | Alliance of Genome Resources | ||||
| osteoarthritis | MMP13* | Mmp13 | Alliance of Genome Resources | ||||
| osteoarthritis | NCOR2* | Ncor2 | Alliance of Genome Resources | ||||
| osteoarthritis | POMC* | Pomc | Alliance of Genome Resources | ||||
| osteoarthritis | PTGS2* | Ptgs2 | Alliance of Genome Resources | ||||
| osteoarthritis | TENT5A* | Tent5a | Alliance of Genome Resources | ||||
| osteoarthritis | TNFRSF11B* | Tnfrsf11b | Alliance of Genome Resources | ||||
| osteomyelitis | HLA-DQB1*, HLA-DQB2 | H2-Ab1 | Alliance of Genome Resources | ||||
| psoriatic arthritis | IL17A* | Il17a | Alliance of Genome Resources | ||||
| psoriatic arthritis | PECAM1* | Pecam1 | Alliance of Genome Resources | ||||
| psoriatic arthritis | PTPN22* | Ptpn22 | Alliance of Genome Resources | ||||
| psoriatic arthritis | STAT3* | Stat3 | Alliance of Genome Resources | ||||
| psoriatic arthritis | STAT4* | Stat4 | Alliance of Genome Resources | ||||
| psoriatic arthritis | TNF* | Tnf | Alliance of Genome Resources | ||||
| psoriatic arthritis | CCR2* | Ccr2 | Alliance of Genome Resources | ||||
| psoriatic arthritis | CYP1A1* | Cyp1a1 | Alliance of Genome Resources | ||||
| psoriatic arthritis | IL13* | Il13 | Alliance of Genome Resources | ||||
| psoriatic arthritis | IRAK1* | Irak1 | Alliance of Genome Resources | ||||
| psoriatic arthritis | LTA* | Lta | Alliance of Genome Resources | ||||
| reactive arthritis | SOD2* | Sod2 | Alliance of Genome Resources | ||||
| reactive arthritis | HLA-B*, HLA-A, HLA-C, HLA-E, HLA-F, HLA-G, HLA-H | H2-D1, H2-K1, H2-L, H2-M1, H2-M2, H2-M3, H2-M5, H2-M9, H2-M10.1, H2-M10.2, H2-M10.3, H2-M10.4, H2-M10.5, H2-M10.6, H2-M11, H2-Q1, H2-Q2, H2-Q4, H2-Q6, H2-Q7, H2-Q8, H2-Q10, H2-T3, H2-T10, H2-T22, H2-T23 | Alliance of Genome Resources | ||||
| reactive arthritis | CYP1A1* | Cyp1a1 | Alliance of Genome Resources | ||||
| reactive arthritis | TAP1* | Tap1 | Alliance of Genome Resources | ||||
| reactive arthritis | TAP2* | Tap2 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | SLC11A1* | Slc11a1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | SLC22A4* | Slc22a4 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | SPP1* | Spp1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | STAT3* | Stat3 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | TAP2* | Tap2 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | THBD* | Thbd | Alliance of Genome Resources | ||||
| rheumatoid arthritis | TNFRSF1A* | Tnfrsf1a | Alliance of Genome Resources | ||||
| rheumatoid arthritis | TYMS* | Tyms | Alliance of Genome Resources | ||||
| rheumatoid arthritis | VDR* | Vdr | Alliance of Genome Resources | ||||
| rheumatoid arthritis | VIM* | Vim | Alliance of Genome Resources | ||||
| rheumatoid arthritis | BGLAP* | Bglap, Bglap2, Bglap3 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | ADRB3* | Adrb3 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | BTNL2* | Btnl2 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | C4B*, C4A, C4B_2 | C4a, C4b | Alliance of Genome Resources | ||||
| rheumatoid arthritis | CAST* | Cast | Alliance of Genome Resources | ||||
| rheumatoid arthritis | CCR1* | Ccr1, Ccr1l1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | CCR5* | Ccr5 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | CD40* | Cd40 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | CD244* | Cd244a | Alliance of Genome Resources | ||||
| rheumatoid arthritis | CIITA* | Ciita | Alliance of Genome Resources | ||||
| rheumatoid arthritis | CLEC16A* | Clec16a | Alliance of Genome Resources | ||||
| rheumatoid arthritis | DNMT3B* | Dnmt3b | Alliance of Genome Resources | ||||
| rheumatoid arthritis | EDN1* | Edn1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | ELN* | Eln | Alliance of Genome Resources | ||||
| rheumatoid arthritis | ESR2* | Esr2 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | FAS* | Fas | Alliance of Genome Resources | ||||
| rheumatoid arthritis | FCGR2A*, FCGR2B, FCGR2C | Fcgr2b, Fcgr3 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | FCGR3A*, FCGR3B | Fcgr4 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | GSTM1*, GSTM5 | Gstm1, Gstm2, Gstm3, Gstm6 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | GSTT1* | Gstt1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | HLA-DQA1*, HLA-DQA2 | H2-Aa | Alliance of Genome Resources | ||||
| rheumatoid arthritis | HLA-DQB1*, HLA-DQB2 | H2-Ab1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | HLA-DRB1*, HLA-DRB3, HLA-DRB4, HLA-DRB5 | H2-Eb1, H2-Eb2 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | HFE* | Hfe | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IFNG* | Ifng | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IGF2* | Igf2 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IL1A* | Il1a | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IL1RN* | Il1rn | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IL2* | Il2 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IL3* | Il3 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IL10* | Il10 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IL4R* | Il4ra | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IL17A* | Il17a | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IL23R* | Il23r | Alliance of Genome Resources | ||||
| rheumatoid arthritis | IRF5* | Irf5 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | ITPA* | Itpa | Alliance of Genome Resources | ||||
| rheumatoid arthritis | KIF5A* | Kif5a | Alliance of Genome Resources | ||||
| rheumatoid arthritis | MBD4* | Mbd4 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | ND1* | mt-Nd1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | MTHFR* | Mthfr | Alliance of Genome Resources | ||||
| rheumatoid arthritis | NCF2* | Ncf2 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | NCF4* | Ncf4 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | NFKBIL1* | Nfkbil1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | NPSR1* | Npsr1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | OPRM1* | Oprm1 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | PLAUR* | Plaur | Alliance of Genome Resources | ||||
| rheumatoid arthritis | PTGS2* | Ptgs2 | Alliance of Genome Resources | ||||
| rheumatoid arthritis | PTPN22* | Ptpn22 | Alliance of Genome Resources | ||||
Excel File
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Transgenes and other genome features developed in mice to model this disease.
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| Disease Term | Transgenes and Other Genome Features | Mouse Models | |
| osteoarthritis | Tg(MT2A-TGFBR2)4Rser | 1 model | |
| rheumatoid arthritis | Tg(CAG-SYVN1)1Tn | 1 model | |
| rheumatoid arthritis | Tg(FCGR2A)11Mkz | 1 model | |
| rheumatoid arthritis | Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz | 1 model | |
| rheumatoid arthritis | Tg(TcraR28,TcrbR28)KRNDim | 2 models | |
| rheumatoid arthritis | Tg(TNF)197Gkl | 1 model | |
| rheumatoid arthritis | Tg(TNF)3647Gkl | 1 model | |