| Disease Term | Human Homologs | Mouse Homologs | Mouse Models | Homology Source | |||
  | acute myeloid leukemia | ASXL1* | Asxl1* | 1 model | Alliance of Genome Resources | ||
| acute myeloid leukemia | CEBPA* | Cebpa* | 1 model | Alliance of Genome Resources | |||
| acute myeloid leukemia | CREBBP* | Crebbp* | 1 model | Alliance of Genome Resources | |||
| acute myeloid leukemia | FLT3* | Flt3* | 4 models | Alliance of Genome Resources | |||
| acute myeloid leukemia | KMT2A* | Kmt2a* | 4 models | Alliance of Genome Resources | |||
| | acute myeloid leukemia | ARID4A | Arid4a* | 2 models | Alliance of Genome Resources | ||
| acute myeloid leukemia | MYBL2 | Mybl2* | 1 model | Alliance of Genome Resources | |||
| acute myeloid leukemia | SPI1 | Spi1* | 1 model | Alliance of Genome Resources | |||
| chronic myeloid leukemia | CHORDC1 | Chordc1* | 1 model | Alliance of Genome Resources | |||
| chronic myeloid leukemia | NCSTN | Ncstn* | 2 models | Alliance of Genome Resources | |||
| chronic myeloid leukemia | SH2B3 | Sh2b3* | 1 model | Alliance of Genome Resources | |||
| chronic myeloid leukemia | SIPA1 | Sipa1* | 2 models | Alliance of Genome Resources | |||
| familial chronic myelocytic leukemia-like syndrome | IRF8 | Irf8* | 4 models | Alliance of Genome Resources | |||
| | acute megakaryocytic leukemia | EZH2* | Ezh2 | Alliance of Genome Resources | |||
| acute megakaryocytic leukemia | MRTFA* | Mrtfa | Alliance of Genome Resources | ||||
| acute megakaryocytic leukemia | JAK3* | Jak3 | Alliance of Genome Resources | ||||
| acute monocytic leukemia | MLLT10* | Mllt10 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | ZRSR2*, ZRSR2P1 | Zrsr2, Zrsr2-ps1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | EPHX1* | Ephx1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | ERCC1* | Ercc1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | ERCC2* | Ercc2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | ETV6* | Etv6 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | EZH2* | Ezh2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | FANCA* | Fanca | Alliance of Genome Resources | ||||
| acute myeloid leukemia | FANCC* | Fancc | Alliance of Genome Resources | ||||
| acute myeloid leukemia | FAS* | Fas | Alliance of Genome Resources | ||||
| acute myeloid leukemia | FGFR1* | Fgfr1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | GATA2* | Gata2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | GFI1* | Gfi1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | GPX1* | Gpx1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | GSTM1*, GSTM5 | Gstm1, Gstm2, Gstm3, Gstm6 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | GSTP1* | Gstp1, Gstp2, Gstp3, Gstp-ps | Alliance of Genome Resources | ||||
| acute myeloid leukemia | GSTT1* | Gstt1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | HLA-DQB1*, HLA-DQB2 | H2-Ab1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | IDH1* | Idh1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | IDH2* | Idh2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | IL1A* | Il1a | Alliance of Genome Resources | ||||
| acute myeloid leukemia | IL6* | Il6 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | ITGAV* | Itgav | Alliance of Genome Resources | ||||
| acute myeloid leukemia | ITGB3* | Itgb3 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | JAK2* | Jak2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | KAT6A* | Kat6a | Alliance of Genome Resources | ||||
| acute myeloid leukemia | KIT* | Kit | Alliance of Genome Resources | ||||
| acute myeloid leukemia | KRAS* | Kras | 1 "NOT" model | Alliance of Genome Resources | |||
| acute myeloid leukemia | LPP* | Lpp | Alliance of Genome Resources | ||||
| acute myeloid leukemia | MEFV* | Mefv | Alliance of Genome Resources | ||||
| acute myeloid leukemia | MLLT10* | Mllt10 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | MTHFR* | Mthfr | Alliance of Genome Resources | ||||
| acute myeloid leukemia | MTRR* | Mtrr | Alliance of Genome Resources | ||||
| acute myeloid leukemia | NAT2*, NAT1 | Nat1, Nat2, Nat3 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | NCOA2* | Ncoa2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | NF1* | Nf1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | NOS3* | Nos3 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | NPM1* | Npm1 | 1 "NOT" model | Alliance of Genome Resources | |||
| acute myeloid leukemia | NQO1* | Nqo1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | NRAS* | Nras | Alliance of Genome Resources | ||||
| acute myeloid leukemia | NSD1* | Nsd1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | NUP214* | Nup214 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | PHF6* | Phf6 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | PICALM* | Picalm | Alliance of Genome Resources | ||||
| acute myeloid leukemia | RUNX1* | Runx1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | SAMHD1* | Samhd1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | SH3GL1* | Sh3gl1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | SOCS1* | Socs1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | SOD2* | Sod2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | SRSF2* | Srsf2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | TERT* | Tert | Alliance of Genome Resources | ||||
| acute myeloid leukemia | TET2* | Tet2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | TFPI2* | Tfpi2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | TP53* | Trp53 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | TYMS* | Tyms | Alliance of Genome Resources | ||||
| acute myeloid leukemia | VEGFA* | Vegfa | Alliance of Genome Resources | ||||
| acute myeloid leukemia | ABL1* | Abl1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | ACSL6* | Acsl6 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | BCL2* | Bcl2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | BMI1*, COMMD3-BMI1 | Bmi1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | BRD7* | Brd7 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CBL* | Cbl | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CCND1* | Ccnd1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CDH1* | Cdh1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CDKN1B* | Cdkn1b | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CDKN2A* | Cdkn2a | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CDKN2B* | Cdkn2b | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CFHR1*, CFHR2 | Cfhr1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CHIC2* | Chic2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CSF2* | Csf2 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CSF3* | Csf3 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CSF3R* | Csf3r | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CTLA4* | Ctla4 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CXCR4* | Cxcr4 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CYP1A1* | Cyp1a1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CYP2B6* | Cyp2b9, Cyp2b10, Cyp2b13, Cyp2b19, Cyp2b23 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | CYP2D6*, CYP2D7 | Cyp2d9, Cyp2d10, Cyp2d11, Cyp2d12, Cyp2d22, Cyp2d26, Cyp2d34, Cyp2d40 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | DLEC1* | Dlec1 | Alliance of Genome Resources | ||||
| acute myeloid leukemia | DNMT3A* | Dnmt3a | Alliance of Genome Resources | ||||
| acute myeloid leukemia | DNMT3B* | Dnmt3b | Alliance of Genome Resources | ||||
| acute myelomonocytic leukemia | FLT3* | Flt3 | Alliance of Genome Resources | ||||
| acute myelomonocytic leukemia | CBFB* | Cbfb | Alliance of Genome Resources | ||||
| acute myelomonocytic leukemia | ARHGAP26* | Arhgap26 | Alliance of Genome Resources | ||||
| acute myelomonocytic leukemia | GMPS* | Gmps | Alliance of Genome Resources | ||||
| acute promyelocytic leukemia | CDKN2B* | Cdkn2b | Alliance of Genome Resources | ||||
| acute promyelocytic leukemia | GSTT1* | Gstt1 | Alliance of Genome Resources | ||||
| acute promyelocytic leukemia | PML* | Pml | 1 model | Alliance of Genome Resources | |||
| acute promyelocytic leukemia | ZBTB16* | Zbtb16 | 1 model | Alliance of Genome Resources | |||
| acute promyelocytic leukemia | RARA* | Rara | Alliance of Genome Resources | ||||
| acute promyelocytic leukemia | MYC* | Bmyc, Myc | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | HLA-DQA1*, HLA-DQA2 | H2-Aa | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | HLA-DQB1*, HLA-DQB2 | H2-Ab1 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | MDM2* | Mdm2 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | MTHFR* | Mthfr | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | NQO1* | Nqo1 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | VEGFA* | Vegfa | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | XRCC1* | Xrcc1 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | IL10* | Il10 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | ABCB1* | Abcb1a, Abcb1b | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | ABCC2* | Abcc2 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | ABCG2* | Abcg2, Abcg3 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | ABL1* | Abl1 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | AKT1* | Akt1 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | BCL2L1* | Bcl2l1 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | BCR* | Bcr | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | CRKL* | Crkl | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | CYP1A1* | Cyp1a1 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | CYP3A5*, CYP3A4, CYP3A7, CYP3A7-CYP3A51P, CYP3A43 | Cyp3a11, Cyp3a13, Cyp3a16, Cyp3a25, Cyp3a41a, Cyp3a41b, Cyp3a44, Cyp3a57, Cyp3a59 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | ERCC2* | Ercc2 | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | FAS* | Fas | Alliance of Genome Resources | ||||
| chronic myeloid leukemia | FASLG* | Fasl | Alliance of Genome Resources | ||||
| myeloid leukemia | PRAME*, PRAMEF1, PRAMEF2, PRAMEF4, PRAMEF5, PRAMEF6, PRAMEF7, PRAMEF8, PRAMEF9, PRAMEF10, PRAMEF11, PRAMEF12, PRAMEF13, PRAMEF15, PRAMEF17, PRAMEF18, PRAMEF19, PRAMEF20, PRAMEF22, PRAMEF25, PRAMEF26, PRAMEF27, PRAMEF33 | Pramel5, Pramel11, Pramel12, Pramel13, Pramel15, Pramel16, Pramel17, Pramel18, Pramel19, Pramel20, Pramel21, Pramel23, Pramel24, Pramel28, Pramel30, Pramel31, Pramel32, Pramel33, Pramel34, Pramel35, Pramel36, Pramel37, Pramel38, Pramel39-ps, Pramel40, Pramel41, Pramel42, Pramel43, Pramel44, Pramel45, Pramel46, Pramel47, Pramel48, Pramel49, Pramel50, Pramel53, Pramel54, Pramel55, Pramel56, Pramel57, Pramel58, Pramel59, Pramel60, Pramel61 | Alliance of Genome Resources | ||||
| myeloid leukemia | PDGFRA* | Pdgfra | Alliance of Genome Resources | ||||
| myeloid leukemia | NSD3* | Nsd3 | Alliance of Genome Resources | ||||
| myeloid leukemia | MN1* | Mn1 | Alliance of Genome Resources | ||||
| myeloid leukemia | IFNG* | Ifng | Alliance of Genome Resources | ||||
| myeloid leukemia | GATA2* | Gata2 | Alliance of Genome Resources | ||||
| myeloid leukemia | FGFR1* | Fgfr1 | Alliance of Genome Resources | ||||
| myeloid leukemia | ERG* | Erg | Alliance of Genome Resources | ||||
| myeloid leukemia | GSTP1* | Gstp1, Gstp2, Gstp3, Gstp-ps | Alliance of Genome Resources | ||||
| myeloid leukemia | UGT1A1* | Ugt1a1 | Alliance of Genome Resources | ||||
| myeloid leukemia | CBX7* | Cbx7 | Alliance of Genome Resources | ||||
| myeloid leukemia | GSTM1*, GSTM5 | Gstm1, Gstm2, Gstm3, Gstm6 | Alliance of Genome Resources | ||||
| myeloid leukemia | GSTT1* | Gstt1 | Alliance of Genome Resources | ||||
| myeloid leukemia associated with Down Syndrome | GATA1* | Gata1 | Alliance of Genome Resources | ||||
Excel File
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Transgenes and other genome features developed in mice to model this disease.
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| Disease Term | Transgenes and Other Genome Features | Mouse Models | |
| acute myeloid leukemia | Tg(CMV-SALL4_iB)#Chai | 1 model | |
| acute myeloid leukemia | Tg(Vav1-Asxl1*Y588X)#Fcy | 1 model | |
| acute myeloid leukemia | Tg(Vav1-ERG)#Jpim | 1 model | |
| acute promyelocytic leukemia | Tg(PML-RARA)556Kog | 2 models | |
| acute promyelocytic leukemia | Tg(CTSG-NUMA1/RARA)#Skr | 1 model | |
| chronic myeloid leukemia | Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg | 1 model | |
| chronic myeloid leukemia | Tg(tetO-BCR/ABL1)2Dgt | 2 models | |
| chronic myeloid leukemia | Tg(Ly6a-BCR/ABL1)IS1AIsg | 1 model | |
| chronic myeloid leukemia | Tg(Ly6a-BCR/ABL1)IS1BIsg | 1 model | |