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All mouse models of synucleinopathy with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | Kufor-Rakeb syndrome | Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd | involves: 129 * C57BL/6 | J:221680 | View | |||
| Parkinson's disease |
Atg7tm1Tchi/Atg7tm1Tchi En1tm2(cre)Wrst/En1+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj | J:192452 | View | ||||
| Parkinson's disease |
En1tm1Gld/En1+ En2tm1Alj/En2tm1Alj |
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster | J:115270 | View | ||||
| Parkinson's disease |
En1tm2Alj/En1+ Tg(Th-EGFP)6-7Okn/? |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J * OF1 | J:214073 | View | ||||
| Parkinson's disease | Nr4a2tm1Omc/Nr4a2+ | involves: 129S7/SvEvBrd * C57BL/6 | J:104902 | View | ||||
| Parkinson's disease | Ppargc1atm1Dpk/Ppargc1atm1Dpk | B6.129X1-Ppargc1atm1Dpk/J | J:298664 | View | ||||
| Parkinson's disease |
Slc6a3tm1(cre)Lrsn/Slc6a3+ Tfamtm1Lrsn/Tfamtm1Lrsn |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL | J:119515 | View | ||||
| Parkinson's disease | Vps35tm1.1Mjff/Vps35tm1.1Mjff | B6.Cg-Vps35tm1.1Mjff | J:303283 | View | ||||
| Parkinson's disease 1 | Sncatm1.1Koks/Snca+ | either: B6.129P2-Sncatm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6) | J:201391 | View | ||||
| Parkinson's disease 1 |
Sncatm1Nbm/Sncatm1Nbm Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm |
involves: 129S6/SvEvTac * FVB/N | J:156741 | View | ||||
| Parkinson's disease 1 |
Sncatm1Nbm/Sncatm1Nbm Tg(SNCA*A53T)1Nbm/Tg(SNCA*A53T)1Nbm Tg(SNCA*A53T)2Nbm/Tg(SNCA*A53T)2Nbm |
involves: 129S6/SvEvTac * FVB/N | J:156741 | View | ||||
| Parkinson's disease 1 | Sncatm1Rosl/Sncatm1Rosl | involves: 129X1/SvJ * C57BL/6 | J:60151 | View | ||||
| Parkinson's disease 1 |
Sncatm1Rosl/Sncatm1Rosl Tg(SNCA)OVX37Rwm/0 |
B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl | J:201991 | View | ||||
| Parkinson's disease 1 |
Sncatm1Rosl/Sncatm1Rosl Tg(SNCA*A30P)192Rwm/0 |
B6.Cg-Sncatm1Rosl Tg(SNCA*A30P)#Rwm | J:201961 | View | ||||
| Parkinson's disease 2 | Prkntm1Ccs/Prkntm1Ccs | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:168847 | View | ||||
| Parkinson's disease 2 | Prkntm1Roo/Prkntm1Roo | either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) | J:85561 | View | ||||
| Parkinson's disease 2 | Prkntm1Roo/Prkntm1Roo | involves: 129S2/SvPas | J:125148 | View | ||||
| Parkinson's disease 2 | Prkntm1Shn/Prkntm1Shn | involves: 129S4/SvJae | J:86377 | View | ||||
| Parkinson's disease 2 | Prkntm1Tmd/Prkntm1Tmd | involves: C57BL/6 | J:91487 | View | ||||
| Parkinson's disease 2 |
Prkntm1Ykt/Prkntm1Ykt Tg(PDGFB-GPR37)20Ryot/0 |
involves: 129P2/OlaHsd * C57BL/6 | J:140326 | View | ||||
| Parkinson's disease 2 |
Prkntm1Ykt/Prkntm1Ykt Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot |
involves: 129P2/OlaHsd * C57BL/6 | J:140326 | View | ||||
| Parkinson's disease 2 |
Prkntm1Ykt/Prkntm1Ykt Tg(Prp-GPR37)1Ryot/0 |
involves: 129P2/OlaHsd * C3H * C57BL/6 | J:140326 | View | ||||
| Parkinson's disease 2 |
Prkntm1Ykt/Prkntm1Ykt Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot |
involves: 129P2/OlaHsd * C3H * C57BL/6 | J:140326 | View | ||||
| Parkinson's disease 4 | Tg(Thy1-Snca)1S13Putt/? | involves: C57BL/6 | J:177661 | View | ||||
| Parkinson's disease 6 | Pink1tm1.1Wrst/Pink1tm1.1Wrst | involves: 129S2/SvPas * BALB/cJ * C57BL/6J | J:183290 | View | ||||
| Parkinson's disease 6 | Pink1tm1Aub/Pink1tm1Aub | involves: 129S/SvEv | J:150206 | View | ||||
| Parkinson's disease 6 | Pink1tm1Hbu/Pink1tm1Hbu | involves: 129S7/SvEvBrd * C57BL/6 | J:169471 | View | ||||
| Parkinson's disease 6 | Pink1tm1Shn/Pink1tm1Shn | involves: 129S4/SvJae * C57BL/6 | J:122728 | View | ||||
| Parkinson's disease 7 | Park7tm1Cai/Park7tm1Cai | involves: 129X1/SvJ * C57BL/6 | J:141628 | View | ||||
| Parkinson's disease 7 | Park7tm1Dsp/Park7tm1Dsp | B6.129P2-Park7tm1Dsp | J:190315 | View | ||||
| Parkinson's disease 7 | Park7tm1Shn/Park7tm1Shn | involves: 129 * C57BL/6 | J:98436 | View | ||||
| Parkinson's disease 7 | Park7tm1Xz/Park7tm1Xz | involves: 129P2/OlaHsd * C57BL/6J | J:99905 | View | ||||
| Parkinson's disease 8 | Tg(Lrrk2*G2019S)2Yue/0 | involves: C3H * C57BL/6 * C57BL/6J | J:157931 | View | ||||
| Parkinson's disease 14 | Pla2g6tm1.1Hlw/Pla2g6tm1.1Hlw | involves: 129 * C57BL/6J | J:317126 | View | ||||
| Parkinson's disease 17 | Vps35Gt(RRK261)Byg/Vps35+ | B6.129P2-Vps35Gt(RRK261)Byg | J:225806 | View | ||||
| Parkinson's disease 17 | Vps35tm1.1Hlw/Vps35+ | involves: 129S/SvEv * C57BL/6J | J:329507 | View | ||||
| | Parkinson's disease | Adcy5tm1Yish/Adcy5tm1Yish | involves: 129X1/SvJ * C57BL/6 | J:83301 | View | |||
| Parkinson's disease | Adh7tm1Gdu/Adh7tm1Gdu | B6.129(Cg)-Adh7tm1Gdu | J:167234 | View | ||||
| Parkinson's disease |
Atg7tm1Tchi/Atg7tm1Tchi Slc6a3tm1(cre)Xz/Slc6a3+ |
involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj | J:192452 | View | ||||
| Parkinson's disease |
Cox10tm1Ctm/Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn/? |
B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn | J:231810 | View | ||||
| Parkinson's disease | Drd2tm1Ebo/Drd2tm1Ebo | involves: 129S2/SvPas * C57BL/6 | J:29045 | View | ||||
| Parkinson's disease | Kcnn2fri/Kcnn2fri | involves: C3H | J:70213 | View | ||||
| Parkinson's disease | Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi | C57BL/6N-Minar2tm1b(KOMP)Wtsi/Wtsi | J:298983 | View | ||||
| Parkinson's disease | nm3/nm3 | involves: RIIIS/J | J:88298 | View | ||||
| Parkinson's disease | Pitx3ak/Pitx3ak | involves: 129S1/Sv * C57BL/6 * C57BLKS/J | J:98209 | View | ||||
| Parkinson's disease | Pitx3eyl/Pitx3eyl | involves: C3H/He * C57BL/6 | J:156878 | View | ||||
| Parkinson's disease |
Pitx3tm1.1Cai/Pitx3+ Tg(tetO-SNCA*A53T)E2Cai/0 |
involves: 129 * C57BL/6J * FVB/N | J:185958 | View | ||||
| Parkinson's disease |
Rrn3tm1.1Igt/Rrn3tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0 |
involves: 129/Sv * C57BL/6 | J:168232, J:242309 | View | ||||
| Parkinson's disease |
Rrn3tm1.1Igt/Rrn3tm1.1Igt Tg(Slc6a3-icre)9190Gsc/0 |
involves: 129/Sv * C57BL/6 * FVB/N | J:168232 | View | ||||
| Parkinson's disease | Sprtm1Lex/Sprtm1Lex | involves: 129S/SvEvBrd * C57BL/6J | J:131376 | View | ||||
| Parkinson's disease | Tg(Th-Twnk*,-EGFP)2Gcor/0 | involves: C57BL/6J | J:188914 | View | ||||
| | Parkinson's disease |
Pink1tm1.1Wrst/Pink1tm1.1Wrst Tg(Prnp-SNCA*A53T)AAub/? |
involves: 129S2/SvPas * C57BL/6J * FVB/N | J:242309 | View | |||
| Parkinson's disease |
Pink1tm1Aub/Pink1tm1Aub Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub |
involves: 129S/SvEv * FVB/N | J:214065 | View | ||||
| Parkinson's disease |
Tg(Thy1-Snca)1S13Putt/0 Uchl1tm1Dgen/Uchl1tm1Dgen |
involves: 129P2/OlaHsd * C57BL/6 | J:207278 | View | ||||
| Transgenes and Other Mutations | multiple system atrophy | Tg(Cnp-SNCA)M2Vle/Tg(Cnp-SNCA)M2Vle | involves: C3H * C57BL/6 | J:99814 | View | |||
| multiple system atrophy | Tg(Mbp-SNCA)1Ema/0 | involves: C57BL/6 * DBA/2 | J:207162 | View | ||||
| multiple system atrophy | Tg(Mbp-SNCA)29Ema/0 | involves: C57BL/6 * DBA/2 | J:102867 | View | ||||
| multiple system atrophy | Tg(Plp1-SNCA)1Haa/0 | involves: C57BL/6 * DBA/2 | J:96778 | View | ||||
| Parkinson's disease | Tg(CAG-SNCA*)1.1Ccs/? | involves: C57BL/6 | J:168847 | View | ||||
| Parkinson's disease |
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-SNCA)0Olri/0 |
involves: C57BL/6 | J:132774 | View | ||||
| Parkinson's disease | Tg(DBH-SNCA)#Dwei/0 | C57BL/6N-Tg(DBH-SNCA)#Dwei | J:296218 | View | ||||
| Parkinson's disease | Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/0 | involves: C57BL/6 | J:132679 | View | ||||
| Parkinson's disease |
Tg(GFAP-tTA)6Hyms/0 Tg(tetO-HMOX1)6Hyms/0 |
involves: FVB/N | J:190573 | View | ||||
| Parkinson's disease | Tg(PDGF-S100B)36Cqin/0 | C57BL/6-Tg(PDGF-S100B)36Cqin | J:173682 | View | ||||
| Parkinson's disease | Tg(Snca-SNCA/GFP)#Jyl/Tg(Snca-SNCA/GFP)#Jyl | involves: C57BL/6 | J:197984 | View | ||||
| Parkinson's disease | Tg(Th-SNCA)5Eric/0 | involves: C57BL/6 * C57BL/6J | J:96494 | View | ||||
| Parkinson's disease | Tg(Th-SNCA)5Eric/Tg(Th-SNCA)5Eric | involves: C57BL/6 | J:140907 | View | ||||
| Parkinson's disease | Tg(Th-SNCA*)1.2Ccs/? | involves: C57BL/6 | J:168847 | View | ||||
| Parkinson's disease | Tg(Th-SNCA*A30P*A53T)39Eric/0 | involves: C57BL/6 * C57BL/6J | J:96494 | View | ||||
| Parkinson's disease 1 | Tg(PDGFB-SNCA)4Ema/0 | involves: C57BL/6 * DBA/2 | J:60638, J:166985 | View | ||||
| Parkinson's disease 1 | Tg(PDGFB-SNCA*A53T)8Ema/0 | Not Specified | J:226922 | View | ||||
| Parkinson's disease 1 | Tg(PDGFB-SNCA/EGFP)78Ema/0 | involves: C57BL/6 * DBA/2 | J:238692 | View | ||||
| Parkinson's disease 1 | Tg(Prnp-SNCA*A53T)25Mkle/0 | involves: C3H/HeJ * C57BL/6J | J:77344 | View | ||||
| Parkinson's disease 1 | Tg(Prnp-SNCA*A53T)83Vle/0 | involves: C3H * C57BL/6 | J:76657 | View | ||||
| Parkinson's disease 1 | Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle | involves: C3H * C57BL/6 | J:76657 | View | ||||
| Parkinson's disease 1 | Tg(Prnp-SNCA*A53T)AAub/? | involves: FVB/N | J:216589 | View | ||||
| Parkinson's disease 1 | Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub | involves: FVB/N | J:181820, J:185489 | View | ||||
| Parkinson's disease 1 | Tg(SNCA)ARyot/0 | C57BL/6J-Tg(SNCA)ARyot | J:185434 | View | ||||
| Parkinson's disease 1 | Tg(SNCA*E46K)3Elan/? | involves: C57BL/6 * SJL | J:200740 | View | ||||
| Parkinson's disease 1 | Tg(Snca-SNCA)#Galt/? | involves: C57BL/6 * DBA/2 | J:199939 | View | ||||
| Parkinson's disease 1 | Tg(Th-SNCA*)1702Yosh/0 | involves: C3H * C57BL/6J | J:125149 | View | ||||
| Parkinson's disease 1 | Tg(Thy1-SNCA)61Ema/0 | involves: C57BL/6 * DBA/2 | J:137490 | View | ||||
| Parkinson's disease 1 | Tg(Thy1-SNCA*)#Ztzh/0 | involves: C57BL/6J | J:313970 | View | ||||
| Parkinson's disease 1 | Tg(Thy1-SNCA*A30P)18Pjk/Tg(Thy1-SNCA*A30P)18Pjk | involves: C57BL/6 | J:80181 | View | ||||
| Parkinson's disease 1 | Tg(THY1-SNCA*A53T)M53Sud/0 | B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J | J:212732 | View | ||||
| Parkinson's disease 1 | Tg(Thy1-SNCA*E57K)16Ema/0 | involves: C57BL/6 * DBA/2 | J:236596 | View | ||||
| Parkinson's disease 2 | Tg(Slc6a3-PARK2*Q311X)AXwy/0 | FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy | J:146833 | View | ||||
| Parkinson's disease 8 | Tg(PDGFB-LRRK2*G2019S)32Hlw/? | FVB/N-Tg(PDGFB-LRRK2*G2019S)32Hlw | J:204793 | View | ||||
| Parkinson's disease 8 | Tg(PDGFB-LRRK2*R1441C)31Hlw/0 | FVB/N-Tg(PDGFB-LRRK2*R1441C)31Hlw | J:229559 | View | ||||
| Additional Complex Models | multiple system atrophy |
Gt(ROSA)26Sortm1(CAG-SNCA)Tanj/Gt(ROSA)26Sortm1(CAG-SNCA)Tanj Tg(Plp1-cre/ERT)3Pop/0 |
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2 | J:283567 | View | |||
| Parkinson's disease |
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+ Mfn2tm3Dcc/Mfn2tm3Dcc Slc6a3tm1.1(cre)Bkmn/Slc6a3+ |
involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J | J:188347 | View | ||||
| Parkinson's disease |
Lmx1atm1Tpe/Lmx1atm1Tpe Lmx1btm1Zfc/Lmx1btm1Zfc Slc6a3tm1(cre)Lrsn/Slc6a3+ |
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 | J:222854 | View | ||||
| Parkinson's disease |
Slc6a3tm2(tTA)Xz/Slc6a3+ Tg(tetO-COX8A/PstI*)1Ctm/0 |
involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL | J:178139 | View | ||||
| Parkinson's disease 1 | 2310039L15RikTg(Prnp-SNCA*A53T)23Mkle/2310039L15Rik+ | involves: C3H/HeJ * C57BL/6J | J:77344 | View | ||||
| Parkinson's disease 1 |
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo 7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+ |
involves: 129 * C57BL/6 | J:150777 | View | ||||
| Parkinson's disease 1 |
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo 7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+ |
involves: 129 * C57BL/6 * SJL | J:150777 | View | ||||
| Parkinson's disease 8 | Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+ | FVB-Khdrbs2Tg(LRRK2*R1441G)135Cjli | J:149135 | View | ||||
| Parkinson's disease 8 | Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+ | FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J | J:204940 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | Parkinson's disease | Drd2tm1Low/Drd2tm1Low | B6.129S2-Drd2tm1Low | J:47001 | View | |||