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All mouse models of benign neoplasm with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | arteriovenous malformations of the brain | Engtm2.1Hma/Engtm2.1Hma | involves: 129P2/OlaHsd | J:196810 | View | |||
| arteriovenous malformations of the brain |
Krastm4Tyj/Kras+ Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129S4/SvJae * FVB | J:312482 | View | ||||
| arteriovenous malformations of the brain |
Krastm4Tyj/Kras+ Tg(Slco1c1-icre/ERT2)1Mash/0 |
involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB | J:312482 | View | ||||
| infantile myofibromatosis | Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo | C57BL/6J-Pdgfrbb2b2903Clo | J:175213 | View | ||||
| pheochromocytoma | Rettm2.1Cos/Rettm2.1Cos | involves: 129S1/Sv * C57BL/6J * FVB/N | J:60659 | View | ||||
| von Hippel-Lindau disease |
Hif1atm3Rsjo/Hif1atm3Rsjo Hprt1tm1(Pck1-cre)Vhh/Y Vhltm1Jae/Vhltm1Jae |
involves: 129 * BALB/c * C57BL/6 | J:97652, J:106705 | View | ||||
| von Hippel-Lindau disease |
Hif1atm3Rsjo/Hif1atm3Rsjo Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129 * BALB/c * C57BL/6 * DBA | J:97652 | View | ||||
| von Hippel-Lindau disease |
Hprt1tm1(Pck1-cre)Vhh/Y Vhltm1Jae/Vhltm1Jae |
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 | J:97652, J:106705 | View | ||||
| von Hippel-Lindau disease |
Ptentm1Hwu/Ptentm1Hwu Vhltm1Jae/Vhltm1Jae Tg(Cdh16-cre)91Igr/0 |
involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR | J:137073 | View | ||||
| von Hippel-Lindau disease |
Ptentm1Hwu/Ptentm1Hwu Vhltm1Jae/Vhltm1Jae Tg(Cdh16-cre)91Igr/0 |
involves: 129S4/SvJae * ICR | J:137442 | View | ||||
| von Hippel-Lindau disease | Vhltm1.1Jae/Vhl+ | involves: 129S4/SvJae * BALB/c | J:67505 | View | ||||
| von Hippel-Lindau disease | Vhltm1.1Lss/Vhl+ | involves: A/J | J:85513 | View | ||||
| von Hippel-Lindau disease | Vhltm1.1Lss/Vhl+ | involves: BALB/c | J:85513 | View | ||||
| von Hippel-Lindau disease | Vhltm1.1Wkr/Vhl+ | involves: 129S4/SvJae * C57BL/6 | J:157369 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA | J:67505, J:97652 | View | ||||
| von Hippel-Lindau disease | Vhltm1Lss/Vhltm1.1Lss | involves: 129X1/SvJ * C57BL/6 | J:85513 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Lss/Vhltm1.1Lss Tg(ACTB-cre)1Tes/0 |
involves: 129X1/SvJ * C3H * C57BL/6 | J:85513 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Lss/Vhltm1Lss Tg(Gcg-cre)1Slib/0 |
either: (involves: 129X1/SvJ * A/J) or (involves: 129X1/SvJ * C57BL/6) | J:148174 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Lss/Vhltm1Lss Tg(Ins2-cre)25Mgn/0 |
either: (involves: 129X1/SvJ * C57BL/6 * DBA) or (involves: 129X1/SvJ * A/J * C57BL/6 * DBA) | J:148174 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Lss/Vhltm1Lss Tg(Pdx1-cre)89.1Dam/0 |
involves: 129X1/SvJ * C57BL/6 * CBA | J:148174 | View | ||||
| von Hippel-Lindau disease | Vhltm1Wml/Vhltm1Wml | involves: 129S4/SvJae * C57BL/6 | J:42846, J:88492 | View | ||||
| | arteriovenous malformations of the brain | Acvrl1tm2.1Spo/Acvrl1tm2.1Spo | involves: 129 | J:196810 | View | |||
| arteriovenous malformations of the brain |
Tg(Tek-tTA)1Rwng/0 Tg(tetO-Notch4*)1Rwng/0 |
involves: FVB/N | J:139943 | View | ||||
| dermoid cyst of ovary |
Foxo3mommeR1/Foxo3mommeR1 Tg(HBA1-GFP)1Ew/Tg(HBA1-GFP)1Ew |
FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew | J:170710 | View | ||||
| epidermal appendage tumor | Tg(Tff3-Tmem207)1Tamo/0 | C57BL/6-Tg(Tff3-Tmem207)1Tamo | J:217436 | View | ||||
| growth hormone secreting pituitary adenoma | Men1tm1Zqw/Men1+ | involves: 129/Sv * 129P2/OlaHsd | J:85302 | View | ||||
| hepatocellular adenoma |
Ptpn11tm1Gsf/Ptpn11tm1Gsf Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA | J:172422 | View | ||||
| prolactinoma | Men1tm1Zqw/Men1+ | involves: 129/Sv * 129P2/OlaHsd | J:85302 | View | ||||
| uterine fibroid |
Tsc2tm1.1Mjg/Tsc2tm1.1Mjg Pgrtm2(cre)Lyd/Pgr+ |
involves: 129S1/Sv * 129X1/SvJ | J:221228 | View | ||||
| | pheochromocytoma |
Ptentm1Mro/Ptentm1Mro Sdhbtm1.1Ics/Sdhb+ Tg(KLK3-cre)D4Trp/0 |
involves: 129S2/SvPas * FVB | J:236514 | View | |||
| Transgenes and Other Mutations | ACTH-secreting pituitary adenoma | Tg(PyLT)1Vb/0 | Not Specified | J:55528 | View | |||
| benign neoplasm |
Tg(Erbb2*)#Maed/0 Tg(Foxa3-cre)1Khk/0 |
involves: C57BL/6 * C57BL/6J * DBA | J:262746 | View | ||||
| choroid plexus papilloma |
Smarcb1tm1Sho/Smarcb1+ Tg(LPV-TAg121)2Tvd/0 |
involves: 129S6/SvEvTac * C57BL/6J * DBA/2J | J:120820 | View | ||||
| choroid plexus papilloma | Tg(LPV-TAg121)2Tvd/0 | involves: 129S6/SvEvTac * C57BL/6J * DBA/2J | J:120820 | View | ||||
| dermoid cyst of ovary | Tg(Amh-SMAD2*)#Jebu/0 | FVB/N-Tg(Amh-SMAD2*)#Jebu | J:200783 | View | ||||
| insulinoma | Tg(RIP1-Tag)2Dh/0 | involves: C57BL/6J * DBA/2J | J:205389 | View | ||||
| lung benign neoplasm |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO/CMV-KRAS*G12C)9.1Msmi/0 |
involves: FVB/N | J:102839 | View | ||||
| lung benign neoplasm |
Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO/CMV-KRAS*G12C)9.1Msmi/0 |
involves: FVB/N | J:102839 | View | ||||
| prolactinoma | Tg(Prl-EGFR)#Sme/0 | Not Specified | J:219654 | View | ||||
| von Hippel-Lindau disease | Tg(Ggt1-Hif1a*)43Log/0 | involves: C57BL/6 | J:177381 | View | ||||
| Additional Complex Models | adenoma |
Krastm4Tyj/Kras+ Ptf1atm1.1(cre)Cvw/Ptf1a+ Tg(MUC1)79.24Gend/0 |
B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw Tg(MUC1)79.24Gend | J:138959 | View | |||
| adenoma |
Rb1tm2Brn/Rb1tm2Brn Trp53tm1Brn/Trp53tm1Brn Tg(Ren-cre)#Kwg/0 |
involves: 129 * 129P2/OlaHsd | J:216559 | View | ||||
| pancreatic mucinous cystadenoma |
Apctm2Rak/Apc+ Trp53tm1Brn/Trp53tm1Brn Tg(Pdx1-cre)6Tuv/0 |
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL | J:234310 | View | ||||
| seborrheic keratosis |
Psen1tm1Bdes/Psen1+ Psen2tm1Bdes/Psen2tm1Bdes |
involves: 129P2/OlaHsd | J:91235 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | paraganglioma |
Sdhctm1c(EUCOMM)Wtsi/Sdhctm1c(EUCOMM)Wtsi Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn/Gt(ROSA)26Sor+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N | J:284745 | View | |||
| paraganglioma | Sdhdtm1Jlob/Sdhd+ | involves: 129X1/SvJ | J:95252 | View | ||||
| paraganglioma | Sdhdtm1Jlob/Sdhdtm1Jlob | involves: 129X1/SvJ | J:95252 | View | ||||
| paraganglioma | Sdhdtm1Jpb/Sdhd+ | either: 129P2/OlaHsd-Sdhdtm1Jpb or (involves: 129P2/OlaHsd * C57BL/6J) | J:155380 | View | ||||
| pheochromocytoma | Rettm1Cos/Rettm2.1Cos | involves: 129S/SvEv * 129S1/Sv * C57BL/6J * FVB/N * MF1 | J:60659 | View | ||||