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All mouse models of RASopathy with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | cardiofaciocutaneous syndrome | Braftm1Bbd/Braf+ | B6.129-Braftm1Bbd | J:170095 | View | |||
| cardiofaciocutaneous syndrome | Braftm1Bbd/Braf+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:170095 | View | ||||
| cardiofaciocutaneous syndrome | Braftm1Bbd/Braf+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1 | J:170095 | View | ||||
| cardiofaciocutaneous syndrome |
Braftm1Tumg/Braf+ Tg(CAG-cre)2Osb/0 |
involves: C57BL * C57BL/6J * DBA | J:216228 | View | ||||
| cardiofaciocutaneous syndrome |
Braftm1Tumg/Braf+ Tg(CAG-cre)2Osb/0 |
involves: C57BL * C57BL/6J * DBA * ICR | J:226977 | View | ||||
| cardiofaciocutaneous syndrome |
Braftm1Wds/Braftm1Wds Raf1tm2Bacc/Raf1tm2Bacc H2az2Tg(Wnt1-cre)11Rth/H2az2+ |
involves: 129P2/OlaHsd * C57BL/6J * CBA/J | J:144862 | View | ||||
| Costello syndrome |
Hrastm1Jaf/Hras+ Tg(CAG-cre)13Miya/0 |
involves: 129S6/SvEvTac * Black Swiss * C57BL/6 | J:204891 | View | ||||
| Costello syndrome | Hrastm2Xbr/Hrastm2Xbr | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N | J:137729 | View | ||||
| neurofibromatosis 1 |
Grin1tm1Stl/Grin1+ Nf1tm1Tyj/Nf1+ |
involves: 129S2/SvPas * C57BL/6J | J:38703 | View | ||||
| neurofibromatosis 1 | Nf1Mhdadsk9/Nf1+ | involves: C3HeB/FeJ * C57BL/6 | J:269534 | View | ||||
| neurofibromatosis 1 |
Nf1tm1.1Kest/Nf1tm1c(KOMP)Wtsi Tg(Dhh-cre)1Mejr/0 |
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * C57BL/6NTac * FVB/N | J:234172 | View | ||||
| neurofibromatosis 1 |
Nf1tm1c(KOMP)Wtsi/Nf1tm1c(KOMP)Wtsi Tg(Dhh-cre)1Mejr/0 |
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N | J:234172 | View | ||||
| neurofibromatosis 1 | Nf1tm1Cbr/Nf1tm1Cbr | involves: 129S1/Sv * C57BL/6 | J:68489 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Fcr/Nf1+ Trp53tm1Tyj/Trp53+ |
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 | J:58877 | View | ||||
| neurofibromatosis 1 | Nf1tm1Fcr/Nf1tm1Fcr | either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) | J:18048 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Par/Nf1tm1Fcr Tg(GFAP-cre)#Gtm/0 |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA | J:165209 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Par/Nf1tm1Par H2az2Tg(Wnt1-cre)11Rth/H2az2+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA | J:80323 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Par/Nf1tm1Par Tg(Fabp7-cre,-lacZ)3Gtm/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA | J:138868 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Par/Nf1tm1Par Tg(Mpz-cre)94Imeg/0 |
involves: 129S1/Sv * 129X1/SvJ | J:80323 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Par/Nf1tm1Par Tg(Pax3-cre)1Joe/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL | J:80323 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Par/Nf1tm1Par Tg(Prrx1-cre)1Cjt/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * SJL/J | J:193350 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Par/Nf1tm1Par Tg(Prrx1-cre)1Cjt/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J | J:173779 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Par/Nf1tm1Par Tg(Syn1-cre)671Jxm/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA | J:68558 | View | ||||
| neurofibromatosis 1 | Nf1tm1Tyj/Nf1+ | involves: 129S2/SvPas * C57BL/6J | J:38703 | View | ||||
| neurofibromatosis 1 |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
involves: 129/Sv * C57BL/6 | J:58876 | View | ||||
| Noonan syndrome 1 |
Emx1tm1(cre)Krj/Emx1+ Ptpn11tm6Bgn/Ptpn11+ |
B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj | J:242312 | View | ||||
| Noonan syndrome 1 | Ptpn11tm1Bgn/Ptpn11+ | involves: 129S4/SvJae * C57BL/6J | J:91609 | View | ||||
| Noonan syndrome 1 | Tg(Myh7-Ptpn11*Q79R)11Rbns/0 | FVB.Cg-Tg(Myh7-Ptpn11*Q79R)11Rbns | J:123963 | View | ||||
| Noonan syndrome 3 | Krastm4.1Bbd/Krastm4.1Bbd | involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N | J:223433 | View | ||||
| Noonan syndrome 4 | Sos1tm1.2Rak/Sos1+ | involves: 129S/Sv * C57BL/6 * FVB/N * SJL | J:171873 | View | ||||
| Noonan syndrome 4 | Sos1tm1.2Rak/Sos1tm1.2Rak | involves: 129S/Sv * C57BL/6 * FVB/N * SJL | J:171873 | View | ||||
| Noonan syndrome 5 | Raf1tm1.1Bgn/Raf1+ | involves: 129S6/SvEvTac * C57BL/6NCr | J:172034 | View | ||||
| Noonan syndrome 5 | Raf1tm2.1Ara/Raf1tm2.1Ara | involves: 129S6/SvEvTac * C57BL/6NCr | J:189143 | View | ||||
| Noonan syndrome 8 | Rit1tm1.1Tumg/Rit1+ | B6.Cg-Rit1tm1.1Tumg | J:277548 | View | ||||
| Noonan syndrome 10 | Lztr1tm1a(EUCOMM)Wtsi/Lztr1+ | involves: C57BL/6N | J:268690 | View | ||||
| vestibular schwannomatosis |
Nf2tm2Gth/Nf2tm2Gth Tg(Postn-cre)1Sjc/0 |
involves: 129P2/OlaHsd * FVB/NTac | J:216420 | View | ||||
| | cardiofaciocutaneous syndrome | Map2k1tm2.1Chrn/Map2k1tm2.1Chrn | involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J | J:261678 | View | |||
| Noonan syndrome | Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr | involves: 129S1/Sv * 129X1/SvJ * NMRI | J:49840 | View | ||||
| Noonan syndrome | Kat6bGt(pKC199)1Pgr/Kat6bGt(pKC199)1Pgr | involves: 129S2/SvPas | J:178264 | View | ||||
| Noonan syndrome with multiple lentigines | Ptpn11tm1.1Ics/Ptpn11+ | involves: 129S2/SvPas * C57BL/6 * FVB/N | J:216593 | View | ||||
| Noonan syndrome with multiple lentigines | Ptpn11tm4.2Bgn/Ptpn11+ | involves: 129S6/SvEvTac * C57BL/6J * FVB/N | J:172033 | View | ||||
| Noonan syndrome with multiple lentigines | Tg(Myh7-Ptpn11*Q510E)#Krnz/0 | FVB/N-Tg(Myh7-Ptpn11*Q510E)#Krnz | J:222124 | View | ||||
| RASopathy | Rreb1em1Rtpl/Rreb1+ | C57BL/6J-Rreb1em1Rtpl | J:296982 | View | ||||
| Transgenes and Other Mutations | Noonan syndrome 1 |
H2az2Tg(Wnt1-cre)11Rth/H2az2+ Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 |
involves: C57BL/6J * CBA/J * FVB/N | J:153094 | View | |||
| Noonan syndrome 1 |
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0 |
involves: C3H * C57BL/6 * FVB/N | J:142212 | View | ||||
| Noonan syndrome with multiple lentigines |
Tg(CAG-cat,-Ptpn11*Q510E)#Krnz/0 Tg(Tek-cre)1Ywa/0 |
involves: C57BL/6 * FVB/N * SJL | J:237450 | View | ||||
| Additional Complex Models | neurofibromatosis 1 |
Krastm4Tyj/Kras+ Ptentm1Hwu/Pten+ Tg(Gfap-cre)77.6Mvs/0 |
involves: 129S4/SvJae * BALB/c * C57BL/6NHsd | J:154673 | View | |||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | neurofibromatosis 1 | Nf1tm1Tyj/Nf1+ | involves: 129S2/SvPas * C57BL/6 | J:18542 | View | |||
| Noonan syndrome 1 | Ptpn11tm1Paw/Ptpn11tm1Paw | involves: 129S1/Sv * 129X1/SvJ * CD-1 | J:43740 | View | ||||
| Noonan syndrome 1 | Ptpn11tm1Rbn/Ptpn11+ | involves: 129 * Black Swiss | J:35137 | View | ||||
| Noonan syndrome 1 | Ptpn11tm1Rbn/Ptpn11tm1Rbn | involves: 129 * Black Swiss | J:35137 | View | ||||