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All mouse models of corneal disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | brittle cornea syndrome 1 | \Zfp469em1Chms/\Zfp469em1Chms | C57BL/6J-Zfp469em1Chms | J:311083 | View | |||
| congenital hereditary endothelial dystrophy of cornea | \Slc4a11tm1.1Jrcy/\Slc4a11tm1.1Jrcy | involves: C57BL/6 | J:214272 | View | ||||
| congenital stromal corneal dystrophy |
\Tg(CAG-cat,-Dcn*)#Debi/0 \Tg(Kera-cre)KC4.3Wwk/0 |
involves: FVB/N | J:177392 | View | ||||
| cornea plana | \Keratm1Cyl/\Keratm1Cyl | involves: 129S6/SvEvTac | J:83873 | View | ||||
| corneal dystrophy | \Tgfbiem1Yaou/\Tgfbiem1Yaou | involves: C57BL/6NCr | J:285437 | View | ||||
| Fuchs' endothelial dystrophy | \Col8a2tm1.1Asj/\Col8a2tm1.1Asj | involves: 129S6/SvEvTac | J:214908 | View | ||||
| Fuchs' endothelial dystrophy | \Col8a2tm1.1Asj/\Col8a2tm1.1Asj | involves: 129S6/SvEvTac * C57BL/6 * CBA | J:179022 | View | ||||
| Fuchs' endothelial dystrophy | \Col8a2tm2.1Asj/\Col8a2tm2.1Asj | involves: 129S6/SvEvTac * C57BL/6 * CBA | J:21908 | View | ||||
| Schnyder corneal dystrophy | \Ubiad1em1Wwk/\Ubiad1+ | C57BL/6N-Ubiad1em1Wwk | J:268574 | View | ||||
| Schnyder corneal dystrophy | \Ubiad1em1Wwk/\Ubiad1em1Wwk | C57BL/6N-Ubiad1em1Wwk | J:268574 | View | ||||
| | keratoconus | \Ppip5k2em1Yul/\Ppip5k2+ | C57BL/6J-Ppip5k2em1Yul | J:360342 | View | |||
| keratoconus | \Ppip5k2em1Yul/\Ppip5k2em1Yul | C57BL/6J-Ppip5k2em1Yul | J:360342 | View | ||||
| keratoconus | \Ppip5k2em2Yul/\Ppip5k2+ | C57BL/6J-Ppip5k2em2Yul | J:360342 | View | ||||
| keratoconus | \Ppip5k2em2Yul/\Ppip5k2em2Yul | C57BL/6J-Ppip5k2em2Yul | J:360342 | View | ||||
| keratoconus | \Ppip5k2tm1b(EUCOMM)Wtsi/\Ppip5k2+ | B6N(Cg)-Ppip5k2tm1b(EUCOMM)Wtsi/J | J:360342 | View | ||||
| keratoconus | \Ppip5k2tm1b(EUCOMM)Wtsi/\Ppip5k2tm1b(EUCOMM)Wtsi | B6N(Cg)-Ppip5k2tm1b(EUCOMM)Wtsi/J | J:360342 | View | ||||
| Peters anomaly | \Pax61Jrt/\Pax6+ | C3.B6-Pax61Jrt | J:86523 | View | ||||
| Peters anomaly | \Pax63Neu/\Pax6+ | either: (involves: 102 * C3H) or (involves: C3H) | J:73625 | View | ||||
| Peters anomaly | \Pax64Neu/\Pax6+ | either: (involves: 102 * C3H) or (involves: C3H) | J:73625 | View | ||||
| Peters anomaly | \Pax67Neu/\Pax6+ | involves: 102 * C3H | J:73625 | View | ||||
| Peters anomaly |
\Pax6tm2Pgr/\Pax6+ \Tg(Pax6-cre,GFP)1Pgr/0 |
involves: 129S1/Sv * 129X1/SvJ * FVB | J:163191 | View | ||||
| sclerocornea | \Rad54lem1Murr/\Rad54l+ | C57BL/6N-Rad54lem1Murr/MurrJ | J:211773 | View | ||||
| Additional Complex Models | Meesmann corneal dystrophy | \Krt12tm1.1(KRT12*L132P)Arte/\Krt12tm1.1(KRT12*L132P)Arte | involves: C57BL/6 | J:229462 | View | |||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | Fuchs' endothelial dystrophy |
\Col8a1tm1Bjro/\Col8a1tm1Bjro \Col8a2tm1Bjro/\Col8a2tm1Bjro |
B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro | J:100136 | View | |||
| Fuchs' endothelial dystrophy | \Col8a2Aca23/\Col8a2+ | C57BL/6J-Col8a2Aca23 | J:158259 | View | ||||
| Fuchs' endothelial dystrophy | \Col8a2Aca23/\Col8a2Aca23 | C57BL/6J-Col8a2Aca23 | J:158259 | View | ||||
| keratoconus | \Vsx1tm1Mci/\Vsx1tm1Mci | either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss) | J:88182 | View | ||||
| keratoconus | \Vsx1tm2Mci/\Vsx1tm2Mci | either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss) | J:88182 | View | ||||