Excel File Text File All mouse models of respiratory system disease with phenotypic similarity to the human disease
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
      asthma Il4ratm1Tch/Il4ratm1Tch involves: 129X1/SvJ * BALB/c J:86215 View
asthma Il4ratm2Tch/Il4ratm2Tch C.129X1-Il4ratm2Tch J:152376 View
lung cancer Cdk6tm1Bbd/Cdk6tm1Bbd
Krastm1Bbd/Kras+
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129S1/Sv * 129X1/SvJ J:161780 View
lung cancer Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
involves: 129S4/SvJae J:195492 View
lung cancer Krastm1Bbd/Kras+ involves: 129S1/Sv * 129X1/SvJ J:172200 View
lung cancer Krastm1Bbd/Kras+
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129S1/Sv * 129X1/SvJ J:161780 View
lung cancer Krastm1Bbd/Krastm2Bbd
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129S1/Sv * 129X1/SvJ J:161780 View
lung cancer Krastm2Tyj/Kras+ involves: 129S2/SvPas J:68981, J:136369 View
lung cancer Krastm2Tyj/Kras+ involves: 129S2/SvPas * C57BL/6 J:68981 View
lung cancer Krastm2Tyj/Kras+
Trp53tm1Glo/Trp53+
involves: 129S2/SvPas * 129S7/SvEvBrd J:129627 View
lung cancer Krastm3Tyj/Kras+ involves: 129S4/SvJae J:68981 View
lung cancer Krastm3Tyj/Kras+ involves: 129S4/SvJae * C57BL/6 J:68981 View
lung cancer Krastm4Tyj/Kras+ involves: 129S4/SvJae J:207982 View
lung cancer Krastm4Tyj/Kras+ involves: 129S4/SvJae * C57BL/6 J:203686 View
lung cancer Krastm4Tyj/Kras+
Scribtm1.1Phum/Scrib+
involves: 129S4/SvJae J:216266 View
lung cancer Krastm4Tyj/Kras+
Scribtm1.1Phum/Scribtm1.1Phum
involves: 129S4/SvJae J:216266 View
lung cancer Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm J:177379 View
lung cancer Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJae J:103407, J:154041, J:195492, J:203686 View
lung cancer Krastm4Tyj/Kras+
Trp53tm1Lejo/Trp53tm1Lejo
involves: 129S4/SvJae J:187012 View
lung cancer Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
involves: 129S4/SvJae J:191425 View
lung cancer Krastm5Tyj/Kras+ involves: 129S4/SvJae * C57BL/6 J:172206 View
pulmonary alveolar proteinosis Abca3tm1Frm/Abca3tm1Frm involves: 129S/SvEv J:120296 View
pulmonary alveolar proteinosis Abca3tm1Holz/Abca3tm1Holz involves: 129S6/SvEvTac * C57BL/6 J:122736 View
pulmonary alveolar proteinosis Abca3tm1Nina/Abca3tm1Nina involves: 129P2/OlaHsd * C57BL/6J J:121155 View
pulmonary alveolar proteinosis Csf2tm1Ard/Csf2tm1Ard involves: 129P2/OlaHsd * C57BL/6 J:18747 View
pulmonary alveolar proteinosis Csf2tm1Mlg/Csf2tm1Mlg involves: 129S2/SvPas J:17978 View
pulmonary alveolar proteinosis Csf2raem1Szut/Csf2raem1Szut C57BL/6-Csf2raem1Szut J:322934 View
pulmonary alveolar proteinosis Csf2rbtm1Mur/Csf2rbtm1Mur involves: 129P2/OlaHsd J:24122 View
pulmonary alveolar proteinosis Csf2rbtm1Mur/Csf2rbtm1Mur involves: 129P2/OlaHsd * C57BL/6 J:35829 View
      asthma Itgb6tm1Des/Itgb6tm1Des involves: 129S4/SvJae * C57BL/6J J:33139 View
asthma Runx3tm1Yg/Runx3tm1Yg either: (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) J:100348 View
asthma Tbx21tm1Glm/Tbx21+ involves: 129S6/SvEvTac * C57BL/6 J:73832 View
asthma Tbx21tm1Glm/Tbx21tm1Glm involves: 129S6/SvEvTac * C57BL/6 J:73832 View
congenital chylothorax Elk3tm1Wlyk/Elk3tm1Wlyk either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) J:71816 View
congenital chylothorax Itga9tm1Des/Itga9tm1Des involves: 129S4/SvJae * C57BL/6 J:63038 View
desquamative interstitial pneumonia Sftpctm1Swg/Sftpctm1Swg either: 129 or (involves: 129 * Black Swiss) J:82925 View
idiopathic pulmonary fibrosis Tg(H2-K-Fosl2,-EGFP)13Wag/0 either: 129.Cg-Tg(H2-K-Fosl2,-EGFP)13Wag or B6.Cg-Tg(H2-K-Fosl2,-EGFP)13Wag J:139032 View
idiopathic pulmonary fibrosis Tg(SFTPC-Tnf)2Pva/0 involves: C57BL/6 * DBA/2 J:28120 View
lung cancer Foxm1tm1Rhc/Foxm1tm1Rhc
Tg(Tek-cre)1Ywa/0
involves: 129X1/SvJ * C57BL/6 * SJL J:167773 View
lung cancer Gadd45atm1Ajf/Gadd45atm1Ajf
Xpctm1Ecf/Xpctm1Ecf
either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6) J:101421 View
lung cancer Robo1tm1Phr/Robo1+ involves: 129P2/OlaHsd * C57BL/6 J:93666 View
lung cancer Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-Fgf9,-EGFP)#Dor/0
involves: FVB J:204282 View
lung cancer Xpctm1Ecf/Xpctm1Ecf involves: 129 * C57BL/6 J:101421 View
meconium aspiration syndrome Atf2tm1Sis/Atf2tm1Sis either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR) J:55657 View
newborn respiratory distress syndrome Epas1tm1Pec/Epas1tm1Pec involves: 129/Sv * Swiss J:77480 View
newborn respiratory distress syndrome Ndst1tm1Ekf/Ndst1tm1Ekf involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:63996 View
newborn respiratory distress syndrome Ndst1tm1Hgx/Ndst1tm1Hgx involves: 129S4/SvJae * C57BL/6 J:60280 View
newborn respiratory distress syndrome Vegfatm1Pec/Vegfatm1Pec involves: 129S1/Sv * 129X1/SvJ J:77480 View
pleuropulmonary blastoma Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-Fgf9,-EGFP)#Dor/0
involves: FVB J:224791 View
pleuropulmonary blastoma Yy1tm2.1Yshi/Yy1tm2.1Yshi
Tg(Nkx2-1-cre)2Sand/0
involves: 129S4/SvJae * C57BL/6J J:239777 View
pulmonary emphysema Bloc1s6pa/Bloc1s6pa B6.Cg-Bloc1s6pa/J J:4098 View
pulmonary emphysema Fstl1tm1Ajn/Fstl1tm1Ajn B6.Cg-Fstl1tm1Ajn J:322116 View
pulmonary emphysema Fut8tm1Nta/Fut8tm1Nta involves: 129S2/SvPas J:102932 View
pulmonary emphysema Gli2tm1(cre/ERT2)Tipe/Gli2+
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
involves: 129X1/SvJ J:264185 View
pulmonary emphysema Itgb6tm1Des/Itgb6tm1Des involves: 129T2/SvEms J:89578 View
pulmonary emphysema Juntm4Wag/Juntm4Wag
Tg(Sftpc-cre)1Blh/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 J:179883 View
pulmonary emphysema Klkl/Klkl either: C.Cg-Klkl or (involves: C3H/HeJ * C57BL/6J) J:44109 View
pulmonary emphysema Mus81tm1Esse/Mus81tm1Esse involves: 129P2/OlaHsd * C57BL/6J J:222498 View
pulmonary emphysema Tg(Actb-Ptma)T12Clwu/0 involves: FVB/N J:270215 View
pulmonary emphysema Tg(Actb-Ptma)T12Clwu/Tg(Actb-Ptma)T12Clwu involves: FVB/N J:270215 View
pulmonary emphysema Tlr4tm1Aki/Tlr4tm1Aki B6.129P2-Tlr4tm1Aki J:114985 View
      pulmonary emphysema Fbn1Tsk/Fbn1+
Tgfb1tm1N/Tgfb1+
involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2 J:68448 View
pulmonary emphysema Serpina1em1Chmu/Serpina1em1Chmu involves: C57BL/6J J:259615 View
pulmonary emphysema Serpina1em2Chmu/Serpina1em2Chmu involves: C57BL/6J J:259615 View
pulmonary emphysema Serpina1em3Chmu/Serpina1em3Chmu involves: C57BL/6J J:259615 View
pulmonary emphysema Serpina1em#Chmu/Serpina1em#Chmu involves: C57BL/6J J:259615 View
Transgenes and
Other Mutations
     adenosquamous lung carcinoma Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-ERBB2*)5BKkw/0
involves: FVB/N J:143874 View
adenosquamous lung carcinoma Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-ERBB2*)26Kkw/0
involves: FVB/N J:143874 View
asthma Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-IL1B)KBry/0
involves: 129 * C57BL/6 J:107601 View
lower respiratory tract disease Tg(AGER)#Eca/Tg(AGER)#Eca C57BL/6J-Tg(AGER)#Eca J:205092 View
lower respiratory tract disease Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-CTGF)#Swu/0
involves: 129 * C57BL/6 * C57BL/6J J:171488 View
lower respiratory tract disease Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-IL1B)KBry/0
involves: 129 * C57BL/6 J:130523 View
lower respiratory tract disease Tg(SFTPC-rtTA)2Jaw/0
Tg(tetO-CTGF)#Swu/0
involves: 129 * C57BL/6 * C57BL/6J J:171151 View
lung adenocarcinoma Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-Kras2)12Hev/0
involves: 129 * C57BL/6 * FVB/N J:73468 View
lung adenocarcinoma Tg(SFTPC-env)1Yhch/0 FVB/N-Tg(SFTPC-env)1Yhch J:247986 View
lung benign neoplasm Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO/CMV-KRAS*G12C)9.1Msmi/0
involves: FVB/N J:102839 View
lung benign neoplasm Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO/CMV-KRAS*G12C)9.1Msmi/0
involves: FVB/N J:102839 View
lung cancer Tg(ACTB-KRAS*G12V,-luc)#Lche/0 involves: C57BL/6 * FVB/N J:199528 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-EGFR*)#Kkw/0
involves: 129 * C57BL/6 * FVB/N J:156440, J:235747 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-EGFR*delta19)11Hev/0
involves: C57BL/6 * CBA J:109092 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-EGFR*L858R)56Hev/0
involves: C57BL/6 * CBA J:109092 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-EGFR*L858R)57Hev/0
involves: C57BL/6 * CBA J:109092 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-EGFR*L858R)#Hev/0
involves: 129 * C57BL/6 * CBA J:128700, J:213447 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-EGFR*T790M)8Paow/0
involves: 129 * C57BL/6 * FVB/N J:128700 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-EGFR*T790M*L858R)19Kkw/0
involves: 129 * C57BL/6 * FVB/N J:122849, J:156440, J:235747 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-EGFR*T790M*L858R)51Paow/0
involves: 129 * C57BL/6 * FVB/N J:128700 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-IGF1R)1Ramo/0
involves: 129 * C57BL/6 * FVB J:271820 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-PIK3CA*H1047R)13Lca/0
involves: 129 * C57BL/6 * FVB/N J:142254 View
lung cancer Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-PTPN11*E76K)#Jiwu/0
involves: 129 * C57BL/6 * FVB/N J:212505 View
lung cancer Tg(SFTPC-CD74/ROS1)125Tno/0 C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno J:231770 View
lung cancer Tg(SFTPC-EGFR*L858R)4-3Kkiu/0 involves: C57BL/6Cr J:152157 View
lung cancer Tg(SFTPC-EML4/ALK)502-4Hima/0 involves: C57BL/6J J:142679 View
lung cancer Tg(SFTPC-env)1Yhch/0 FVB/N-Tg(SFTPC-env)1Yhch J:153538 View
lung cancer Tg(SFTPC-EZR/ROS1)AShiba/0 C57BL/6-Tg(SFTPC-EZR/ROS1)AShiba J:199415 View
lung cancer Tg(SFTPC-KIF5B/RET)1Tkoh/0 involves: C57BL/6J J:215989 View
lung cancer Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-IGF1R)1Ramo/0
involves: FVB J:271820 View
lung cancer Tg(SFTPC-SDC4/ROS1)141Tno/0 C57BL/6J-Tg(SFTPC-SDC4/ROS1)141Tno J:231770 View
lung cancer Tg(Utg-TAg)7593Fjd/? involves: FVB J:70785 View
lung cancer Tg(Utg-TAg)7736Fjd/? involves: FVB J:70785 View
lung cancer Tg(Utg-TAg)#Fjd/? involves: FVB J:70785 View
pulmonary emphysema Tg(HP-MMP1a)34-1Cha/0 involves: C57BL/6J * CBA/J J:164058 View
pulmonary emphysema Tg(HP-MMP1a)34-1Cha/Tg(HP-MMP1a)34-1Cha involves: C57BL/6J * CBA/J J:164058 View
pulmonary emphysema Tg(Msr1-MMP9)#Apar/0 B6.Cg-Tg(Msr1-MMP9)#Apar J:136830 View
pulmonary emphysema Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-PLAGL2)P3Ysy/0
involves: FVB/N J:152422 View
pulmonary fibrosis Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-TGFA)22.1Kor/0
involves: 129 * C57BL/6 * FVB/NJ J:240947 View
Additional
Complex
Models
     lower respiratory tract disease Fgfr3tm1Led/Fgfr3tm1Led
Fgfr4tm1Cxd/Fgfr4tm1Cxd
involves: 129S6/SvEvTac * Black Swiss J:50677 View
lung cancer Col1a1tm1(CAG-EGFR*T790M*C797S*L858R)Mje/Col1a1+ involves: 129S4/SvJae * BALB/c * C57BL/6 J:235747 View
lung cancer Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+
Tg(Scgb1a1-rtTA)1Jaw/0
involves: 129 * C57BL/6 J:166724 View
lung cancer Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+ involves: 129S4/SvJae * BALB/c * C57BL/6 J:214230 View
lung cancer Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 J:214230 View
lung cancer Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 J:214230 View
lung cancer Ctnnb1tm1Mmt/Ctnnb1+
Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0
involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N J:174242 View
lung non-small cell carcinoma Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+
Tg(Scgb1a1-rtTA)1Jaw/0
involves: 129 * C57BL/6 J:166724 View
lung non-small cell carcinoma Krastm4Tyj/Kras+
Stk11tm1.1Rdp/Stk11tm1.1Rdp
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N J:124682 View
lung non-small cell carcinoma Krastm4Tyj/Kras+
Stk11tm1.1Rdp/Stk11tm1.2Rdp
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N J:124682 View
lung small cell carcinoma Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd J:86077, J:157319 View
lung small cell carcinoma Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Lejo/Trp53tm1Lejo
involves: 129 J:187012 View
lung small cell carcinoma Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2Tyj/Rbl2tm2Tyj
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJae J:160148 View
lung small cell carcinoma Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJae J:160148 View
lung squamous cell carcinoma Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:234268 View
pulmonary emphysema Fbn1Tsk/Fbn1+ B6.Cg-Fbn1Tsk J:30961, J:6566, J:15018, J:1326, J:68448 View
pulmonary emphysema Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ra+
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2 J:68448 View
pulmonary emphysema Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ratm1Sz
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2 J:68448 View
sinusitis Cyp2g1tm1(rtTA)Lane/Cyp2g1+
Tg(SFTPC-rtTA,tetO-Tnf)320-1Gwho/0
involves: 129 * C57BL/6 * SJL J:157842 View


       
No similarity to the expected human disease phenotype was found.
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
NOT Models      asthma Adam33tm1.1Chch/Adam33tm1.1Chch 129S4/SvJae-Adam33tm1.1Chch J:112306 View
chronic obstructive pulmonary disease Htr4tm1Comp/Htr4tm1Comp B6.129S1(129T)-Htr4tm1Comp J:261502 View
pulmonary emphysema Itgb6tm1Des/Itgb6tm1Des
Mmp12tm1Sds/Mmp12tm1Sds
involves: 129/Sv * 129T2/SvEms J:89578 View