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All mouse models of vascular disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | aortic aneurysm |
Agtr2tm1Tin/Y Efemp2tm1.1Hiya/Efemp2tm1.2Hiya Tg(Tagln-cre)1Her/0 |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL | J:213282 | View | |||
| aortic aneurysm |
Efemp2tm1.1Hiya/Efemp2tm1.2Hiya Tg(Tagln-cre)1Her/0 |
involves: 129S6/SvEvTac * C57BL/6 * SJL | J:213282 | View | ||||
| arterial calcification of infancy | Enpp1asj-2J/Enpp1asj-2J | BALB/cJ-Enpp1asj-2J/GrsrJ | J:215824 | View | ||||
| arterial calcification of infancy | Enpp1asj/Enpp1asj | C57BL/6J-Enpp1asj/GrsrJ | J:201689 | View | ||||
| arteriovenous malformations of the brain | Engtm2.1Hma/Engtm2.1Hma | involves: 129P2/OlaHsd | J:196810 | View | ||||
| arteriovenous malformations of the brain |
Krastm4Tyj/Kras+ Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129S4/SvJae * FVB | J:312482 | View | ||||
| arteriovenous malformations of the brain |
Krastm4Tyj/Kras+ Tg(Slco1c1-icre/ERT2)1Mash/0 |
involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB | J:312482 | View | ||||
| cerebral cavernous malformation |
Krit1tm1Kwhi/Krit1tm1Kwhi Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129S6/SvEvTac * C57BL/6NCrl | J:232707, J:250906 | View | ||||
| cerebral cavernous malformation 2 |
Ccm2tm1.1Etl/Ccm2tm1Etl Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129 * C57BL/6 | J:177584 | View | ||||
| cerebral cavernous malformation 2 |
Ccm2tm1Kwhi/Ccm2tm1.1Kwhi Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/? |
involves: C57BL/6 * CBA | J:173947 | View | ||||
| cerebral cavernous malformation 2 |
Ccm2tm1Mlkn/Ccm2tm1Mlkn Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129 | J:250906 | View | ||||
| cerebral cavernous malformation 2 |
Ccm2tm2.1Sbn/Ccm2tm2.1Sbn Tg(Mx1-cre)1Cgn/0 |
involves: C57BL/6 * CBA | J:174085 | View | ||||
| cerebral cavernous malformation 3 |
Pdcd10tm1Kwhi/Pdcd10tm1.1Kwhi Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/? |
involves: C57BL/6 * CBA | J:173947 | View | ||||
| cerebral cavernous malformation 3 |
Pdcd10tm1Wami/Pdcd10tm1Wami Tg(GFAP-cre)25Mes/0 |
involves: 129 * C57BL/6 * FVB/N | J:170480 | View | ||||
| essential hypertension | Nos3tm1Gdk/Nos3tm1Gdk | involves: 129P2/OlaHsd * C57BL/6 | J:46061 | View | ||||
| essential hypertension | Nos3tm1Plh/Nos3tm1Plh | involves: 129S4/SvJae | J:28778 | View | ||||
| essential hypertension | Nos3tm1Unc/Nos3tm1Unc | involves: 129P2/OlaHsd | J:103153 | View | ||||
| hereditary hemorrhagic telangiectasia | Acvrl1tm1Enl/Acvrl1+ | involves: C57BL/6 | J:82115 | View | ||||
| hereditary hemorrhagic telangiectasia |
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ |
involves: 129 * 129S1/Sv * 129X1/SvJ | J:154620 | View | ||||
| hereditary hemorrhagic telangiectasia |
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 |
involves: 129 * FVB | J:154620 | View | ||||
| hereditary hemorrhagic telangiectasia |
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Tg(Tal1-cre/ERT)1Jrg/0 |
involves: 129 * C57BL/6 | J:227170 | View | ||||
| hereditary hemorrhagic telangiectasia |
Acvrl1tm2Spo/Acvrl1tm2Spo Tg(Acvrl1-cre)L1Spo/0 |
involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N | J:130020 | View | ||||
| hereditary hemorrhagic telangiectasia | Engtm1Dyl/Engtm1Dyl | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:55403 | View | ||||
| hereditary hemorrhagic telangiectasia | Engtm1Hma/Eng+ | 129P2/OlaHsd-Engtm1Hma | J:73415 | View | ||||
| hereditary hemorrhagic telangiectasia | Engtm1Mle/Eng+ | 129P2/OlaHsd-Engtm1Mle | J:58502 | View | ||||
| hereditary hemorrhagic telangiectasia | Engtm1Mle/Eng+ | involves: 129P2/OlaHsd * C57BL/6 | J:58502 | View | ||||
| hereditary hemorrhagic telangiectasia |
Engtm2.1Hma/Engtm2.1Hma Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ | J:212952, J:227170 | View | ||||
| hereditary hemorrhagic telangiectasia |
Engtm2.1Hma/Engtm2.1Hma Tg(Tagln-cre)1Her/0 |
involves: 129P2/OlaHsd * C57BL/6 * SJL | J:212952 | View | ||||
| Marfan syndrome | Fbn1tm1Hcd/Fbn1+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:91349, J:94428 | View | ||||
| Marfan syndrome | Fbn1tm1Lper/Fbn1+ | involves: 129/Sv * C57BL/6 * CD-1 | J:167276 | View | ||||
| Marfan syndrome | Fbn1tm1Lper/Fbn1+ | involves: 129/Sv * CD-1 | J:167276 | View | ||||
| Marfan syndrome | Fbn1tm1Rmz/Fbn1tm1Rmz | involves: 129S4/SvJae * C57BL/6J | J:43199 | View | ||||
| Marfan syndrome | Fbn1tm2Rmz/Fbn1tm2Rmz | involves: 129S1/Sv * 129X1/SvJ | J:54081 | View | ||||
| Marfan syndrome | Fbn1tm3Rmz/Fbn1tm3Rmz | Not Specified | J:110586 | View | ||||
| Marfan syndrome | Fbn1Tsk/Fbn1+ | B6.Cg-Fbn1Tsk | J:30961 | View | ||||
| Marfan syndrome | Fbn1Tsk/Fbn1+ | B10.D2/(58N)Sn | J:21512 | View | ||||
| persistent fetal circulation syndrome | Foxf1em1Vvk/Foxf1+ | involves: C57BL/6 * DBA/2 | J:296328 | View | ||||
| supravalvular aortic stenosis | Elntm1Dyl/Eln+ | B6.129-Elntm1Dyl | J:86535 | View | ||||
| supravalvular aortic stenosis | Elntm1Dyl/Eln+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:51109 | View | ||||
| von Hippel-Lindau disease |
Hif1atm3Rsjo/Hif1atm3Rsjo Hprt1tm1(Pck1-cre)Vhh/Y Vhltm1Jae/Vhltm1Jae |
involves: 129 * BALB/c * C57BL/6 | J:97652, J:106705 | View | ||||
| von Hippel-Lindau disease |
Hif1atm3Rsjo/Hif1atm3Rsjo Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129 * BALB/c * C57BL/6 * DBA | J:97652 | View | ||||
| von Hippel-Lindau disease |
Hprt1tm1(Pck1-cre)Vhh/Y Vhltm1Jae/Vhltm1Jae |
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 | J:97652, J:106705 | View | ||||
| von Hippel-Lindau disease |
Ptentm1Hwu/Ptentm1Hwu Vhltm1Jae/Vhltm1Jae Tg(Cdh16-cre)91Igr/0 |
involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR | J:137073 | View | ||||
| von Hippel-Lindau disease |
Ptentm1Hwu/Ptentm1Hwu Vhltm1Jae/Vhltm1Jae Tg(Cdh16-cre)91Igr/0 |
involves: 129S4/SvJae * ICR | J:137442 | View | ||||
| von Hippel-Lindau disease | Vhltm1.1Jae/Vhl+ | involves: 129S4/SvJae * BALB/c | J:67505 | View | ||||
| von Hippel-Lindau disease | Vhltm1.1Lss/Vhl+ | involves: A/J | J:85513 | View | ||||
| von Hippel-Lindau disease | Vhltm1.1Lss/Vhl+ | involves: BALB/c | J:85513 | View | ||||
| von Hippel-Lindau disease | Vhltm1.1Wkr/Vhl+ | involves: 129S4/SvJae * C57BL/6 | J:157369 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA | J:67505, J:97652 | View | ||||
| von Hippel-Lindau disease | Vhltm1Lss/Vhltm1.1Lss | involves: 129X1/SvJ * C57BL/6 | J:85513 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Lss/Vhltm1.1Lss Tg(ACTB-cre)1Tes/0 |
involves: 129X1/SvJ * C3H * C57BL/6 | J:85513 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Lss/Vhltm1Lss Tg(Gcg-cre)1Slib/0 |
either: (involves: 129X1/SvJ * A/J) or (involves: 129X1/SvJ * C57BL/6) | J:148174 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Lss/Vhltm1Lss Tg(Ins2-cre)25Mgn/0 |
either: (involves: 129X1/SvJ * C57BL/6 * DBA) or (involves: 129X1/SvJ * A/J * C57BL/6 * DBA) | J:148174 | View | ||||
| von Hippel-Lindau disease |
Vhltm1Lss/Vhltm1Lss Tg(Pdx1-cre)89.1Dam/0 |
involves: 129X1/SvJ * C57BL/6 * CBA | J:148174 | View | ||||
| von Hippel-Lindau disease | Vhltm1Wml/Vhltm1Wml | involves: 129S4/SvJae * C57BL/6 | J:42846, J:88492 | View | ||||
| | aortic aneurysm | Atp7aMo-blo/Atp7a+ | Not Specified | J:5516 | View | |||
| aortic aneurysm | Atp7aMo-blo/Y | Not Specified | J:5516, J:15796 | View | ||||
| aortic aneurysm | Klf15tm1Jain/Klf15tm1Jain | B6.129X1-Klf15tm1Jain | J:167880 | View | ||||
| aortic dissection |
Best3tm1.1Zhoj/Best3tm1.1Zhoj Tg(Tagln-cre)1Her/0 |
involves: C57BL/6 * SJL | J:338981 | View | ||||
| aortic valve disease | Adamts19tm4a(EUCOMM)Wtsi/Adamts19tm4a(EUCOMM)Wtsi | C57BL/6N-Adamts19tm4a(EUCOMM)Wtsi | J:287334 | View | ||||
| aortic valve disease | Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi | B6N(Cg)-Adamts19tm4b(EUCOMM)Wtsi | J:287334 | View | ||||
| aortic valve disease | Egfrwa2/Egfrwa2 | involves: C57BL/6 | J:241813 | View | ||||
| aortic valve disease | Egfrwa2/Egfrwa2 | STOCK Egfrwa2 | J:60750 | View | ||||
| aortic valve disease | Elntm1Dyl/Eln+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:184494 | View | ||||
| aortic valve disease | Hey2tm1Kkb/Hey2tm1Kkb | involves: 129S7/SvEvBrd * C57BL/6 | J:216895 | View | ||||
| aortic valve disease | Nos3tm1Unc/Nos3tm1Unc | B6.129P2-Nos3tm1Unc/J | J:103340 | View | ||||
| aortic valve disease | Rbpjtm1Kyo/Rbpj+ | involves: 129S2/SvPas * CD-1 | J:187551 | View | ||||
| aortic valve stenosis | Tnftm2Gkl/Tnf+ | involves: 129S/SvEv * C57BL/6J | J:264147 | View | ||||
| arteriovenous malformations of the brain | Acvrl1tm2.1Spo/Acvrl1tm2.1Spo | involves: 129 | J:196810 | View | ||||
| arteriovenous malformations of the brain |
Tg(Tek-tTA)1Rwng/0 Tg(tetO-Notch4*)1Rwng/0 |
involves: FVB/N | J:139943 | View | ||||
| Caroli syndrome | Pkhd1cyli/Pkhd1cyli | D2.Cg-(D4Mit42-D4Smh6b) Pkhd1cyli/EiJ | J:343537 | View | ||||
| coronary artery disease | Kcnj8tm1Sse/Kcnj8tm1Sse | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:76195 | View | ||||
| diabetic retinopathy |
Insrtm1Khn/Insrtm1Khn Tg(Pdgfrb-cre)#Rha/0 |
involves: 129S4/SvJae * C57BL/6J | J:327000 | View | ||||
| essential hypertension | Elntm1Dyl/Eln+ | B6.129-Elntm1Dyl | J:86535 | View | ||||
| essential hypertension | Gata5tm1.2Nemr/Gata5tm1.2Nemr | Not Specified | J:227997 | View | ||||
| exudative vitreoretinopathy |
Cdh5tm1Dvst/Cdh5tm1Dvst Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 |
involves: C57BL/6 * CBA | J:328283 | View | ||||
| exudative vitreoretinopathy |
Ctnnb1em1V/Ctnnb1em1V Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 |
involves: C57BL/6 * C57BL/6J * CBA | J:328283 | View | ||||
| exudative vitreoretinopathy | Fzd4tm1Nat/Fzd4tm1Nat | involves: 129S1/Sv * 129X1/SvJ | J:158585 | View | ||||
| exudative vitreoretinopathy | Fzd4tm1Nat/Fzd4tm1Nat | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:328283 | View | ||||
| exudative vitreoretinopathy | Lrp5em1Xjz/Lrp5em1Xjz | C57BL/6J-Lrp5em1Xjz | J:328283 | View | ||||
| exudative vitreoretinopathy | Lrp5r18/Lrp5r18 | C57BL/6J-Lrp5r18 | J:135279 | View | ||||
| exudative vitreoretinopathy | Lrp5tm1Dgen/Lrp5tm1Dgen | B6.129P2-Lrp5tm1Dgen/J | J:235600 | View | ||||
| exudative vitreoretinopathy | Lrp5tm1Dgen/Lrp5tm1Dgen | involves: 129P2/OlaHsd * C57BL/6 | J:328283 | View | ||||
| exudative vitreoretinopathy | Ndptm1Wbrg/Y | involves: 129P2/OlaHsd * C57BL/6 | J:158585 | View | ||||
| exudative vitreoretinopathy | Tspan12tm1Wye/Tspan12tm1Wye | either: B6.129S5-Tspan12tm1Wye or FVB.129S5-Tspan12tm1Wye | J:158585 | View | ||||
| hypertension | Nppatm1Unc/Nppa+ | involves: 129P2/OlaHsd * C57BL/6J | J:76312 | View | ||||
| hypertension | Nppatm1Unc/Nppatm1Unc | involves: 129P2/OlaHsd * C57BL/6 | J:76312 | View | ||||
| Marfan syndrome | Mus81tm1Esse/Mus81tm1Esse | involves: 129P2/OlaHsd * C57BL/6 | J:133703 | View | ||||
| persistent fetal circulation syndrome | Nos3tm1Unc/Nos3tm1Unc | B6.129P2-Nos3tm1Unc/J | J:98913 | View | ||||
| persistent fetal circulation syndrome |
Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ |
B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu | J:192736 | View | ||||
| pre-eclampsia | Apelatm1.2Brre/Apelatm1.2Brre | B6(Cg)-Apelatm1.2Brre | J:244834 | View | ||||
| pre-eclampsia | Asb4tm1.2Cpat/Asb4tm1.2Cpat | involves: 129/SvEv | J:238841 | View | ||||
| pre-eclampsia | Cdkn1ctm1Kat/Cdkn1c+ | involves: 129P2/OlaHsd | J:102331 | View | ||||
| pre-eclampsia | Cdkn1ctm1Kat/Cdkn1ctm1Kat | involves: 129P2/OlaHsd | J:102331 | View | ||||
| pre-eclampsia | Comttm1Kara/Comttm1Kara | involves: 129S4/SvJaeSor | J:137276 | View | ||||
| pre-eclampsia | Ido1tm1.1Mkks/Ido1tm1.1Mkks | B6.Cg-Ido1tm1.1Mkks | J:229059 | View | ||||
| pre-eclampsia |
Notch2tm3Grid/Notch2tm3Grid Tg(Tpbpa-cre,-EGFP)5Jcc/0 |
involves: 129S1/Sv | J:173527 | View | ||||
| pre-eclampsia | Ptgs1tm1Fun/Ptgs1tm1Fun | involves: 129S6/SvEvTac * C57BL/6 | J:97351 | View | ||||
| pulmonary hypertension | Cavin1tm1Pfp/Cavin1tm1Pfp | B6.129S6-Cavin1tm1Pfp/J | J:217258 | View | ||||
| retinal vein occlusion | Nrp1tm1.1Cruh/Nrp1tm1.1Cruh | involves: C57BL/6 | J:176047 | View | ||||
| severe nonproliferative diabetic retinopathy | Pdgfrbredeye/Pdgfrbredeye | C3N.C-Pdgfrbredeye | J:199483 | View | ||||
| | coronary artery disease |
Apoetm1Unc/Apoetm1Unc Scarb1tm1Kri/Scarb1tm1Kri |
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 | J:201999 | View | |||
| Transgenes and Other Mutations | brain ischemia | Tg(Notch3*R169C)88Bbb/0 | involves: FVB/N | J:156682 | View | |||
| von Hippel-Lindau disease | Tg(Ggt1-Hif1a*)43Log/0 | involves: C57BL/6 | J:177381 | View | ||||
| Additional Complex Models | aortic valve disease |
Apobtm2Sgy/Apobtm2Sgy Ldlrtm1Her/Ldlrtm1Her Tg(Ins-Igf2)1Fbos/? |
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL | J:227165 | View | |||
| coronary artery disease | Abcc9tm1Cfb/Abcc9tm1Cfb | Not Specified | J:78066 | View | ||||
| diabetic angiopathy |
Ins2Akita/Ins2Akita Ldlrtm1Her/Ldlrtm1Her |
B6.Cg-Ins2Akita Ldlrtm1Her | J:174983 | View | ||||
| exudative vitreoretinopathy |
Ctnna1em1Xjz/Ctnna1tm1Efu Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 |
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6J * C57BL/6NCrl * CBA | J:328283 | View | ||||
| exudative vitreoretinopathy |
Ctnna1tm1Efu/Ctnna1tm1Efu Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 |
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6NCrl * CBA | J:328283 | View | ||||
| pre-eclampsia |
Adatm1Mw/Adatm1Mw Tg(Afp-ADA)#Xiay/0 |
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J | J:234143 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | cerebral cavernous malformation 2 |
Ccm2tm1Etl/Ccm2tm1Etl Tg(Nes-cre)1Kln/? |
B6.Cg-Ccm2tm1Etl Tg(Nes-cre)1Kln | J:146210 | View | |||
| cerebral cavernous malformation 2 |
Ccm2tm2.1Sbn/Ccm2tm2.1Sbn Tg(Tek-cre)1Ywa/0 |
involves: C57BL/6 * SJL | J:174085 | View | ||||
| coronary artery disease |
Apoetm1Unc/Apoetm1Unc Svep1em1Nost/Svep1em1Nost |
involves: 129P2/OlaHsd * C57BL/6 | J:304349 | View | ||||
| essential hypertension | Tnfrsf1btm1Imx/Tnfrsf1btm1Imx | involves: 129S7/SvEvBrd * C57BL/6 | J:45147 | View | ||||
| Marfan syndrome | Fbn1tm3.2Lysa/Fbn1+ | Not Specified | J:181493 | View | ||||
| Marfan syndrome | Fbn1tm3.2Lysa/Fbn1tm3.2Lysa | Not Specified | J:181493 | View | ||||
| Moyamoya disease | Rnf213tm1.1Mfuji/Rnf213tm1.1Mfuji | involves: C57BL/6 | J:229422 | View | ||||