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All mouse models of epilepsy with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | autosomal dominant nocturnal frontal lobe epilepsy 3 | Chrnb2tm1.1Cont/Chrnb2tm1.1Cont | B6.129-Chrnb2tm1.1Cont | J:228269 | View | |||
| autosomal dominant nocturnal frontal lobe epilepsy 3 |
Tg(Prnp-tTA)F959Sbp/0 Tg(tetO-Chrnb2*V287L)H3Gica/0 |
involves: 129S7/SvEvBrd * FVB | J:145855 | View | ||||
| benign neonatal seizures | Kcnq2tm1.1Naas/Kcnq2+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:154582 | View | ||||
| benign neonatal seizures | Kcnq2tm1.1Naas/Kcnq2tm1.1Naas | B6.129-Kcnq2tm1.1Naas | J:154582 | View | ||||
| benign neonatal seizures | Kcnq2tm1.1Naas/Kcnq2tm1.1Naas | FVB.129-Kcnq2tm1.1Naas | J:154582 | View | ||||
| benign neonatal seizures | Kcnq2tm1.1Naas/Kcnq2tm1.1Naas | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:154582 | View | ||||
| benign neonatal seizures | Kcnq2tm1Hsa/Kcnq2+ | involves: 129P2/OlaHsd * C57BL/6 | J:62797 | View | ||||
| benign neonatal seizures | Kcnq3tm1.1Naas/Kcnq3+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:154582 | View | ||||
| benign neonatal seizures | Kcnq3tm1.1Naas/Kcnq3+ | involves: 129S1/Sv * 129X1/SvJ * FVB/N | J:154582 | View | ||||
| benign neonatal seizures | Kcnq3tm1.1Naas/Kcnq3tm1.1Naas | B6.129-Kcnq3tm1.1Naas | J:154582 | View | ||||
| benign neonatal seizures | Kcnq3tm1.1Naas/Kcnq3tm1.1Naas | FVB.129-Kcnq3tm1.1Naas | J:154582 | View | ||||
| benign neonatal seizures | Kcnq3tm1.1Naas/Kcnq3tm1.1Naas | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:154582 | View | ||||
| developmental and epileptic encephalopathy 2 | Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr | involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J | J:209635 | View | ||||
| developmental and epileptic encephalopathy 2 | Cdkl5tm1.2Cogr/Y | involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J | J:209635 | View | ||||
| developmental and epileptic encephalopathy 7 | Kcnq2tm1.1Lvi/Kcnq2+ | 129-Kcnq2tm1.1Lvi/Lvi | J:298666 | View | ||||
| developmental and epileptic encephalopathy 14 | Kcnt1em1Lekk/Kcnt1+ | C57BL/6J-Kcnt1em1Lekk | J:287751 | View | ||||
| developmental and epileptic encephalopathy 14 | Kcnt1em1Pqt/Kcnt1em1Pqt | C57BL/6J-Kcnt1em1Pqt | J:333512 | View | ||||
| developmental and epileptic encephalopathy 16 | Tbc1d24em2Tbf/Tbc1d24em2Tbf | C57BL/6J-Tbc1d24em2Tbf | J:273646 | View | ||||
| developmental and epileptic encephalopathy 17 | Gnao1em1Rneu/Gnao1+ | involves: C57BL/6J * C57BL/6NCrl | J:271137 | View | ||||
| developmental and epileptic encephalopathy 17 | Gnao1tm2.1Rneu/Gnao1+ | B6.129S-Gnao1tm2.1Rneu | J:216850 | View | ||||
| developmental and epileptic encephalopathy 17 | Gnao1tm2Rneu/Gnao1+ | B6.129S1-Gnao1tm2Rneu | J:271137 | View | ||||
| developmental and epileptic encephalopathy 39 | Slc25a12Gt(OST123999)Lex/Slc25a12Gt(OST123999)Lex | involves: 129S5/SvEvBrd * C57BL/6 | J:243212 | View | ||||
| developmental and epileptic encephalopathy 54 | Hnrnpuem1Frk/Hnrnpu+ | Not Specified | J:342579 | View | ||||
| Dravet syndrome | Scn1atm1.1Kzy/Scn1a+ | involves: 129P2/OlaHsd * C3HeB/FeJ | J:260796 | View | ||||
| Dravet syndrome | Scn1atm1Kea/Scn1a+ | (C57BL/6J x 129S6/SvEvTac-Scn1atm1Kea)F1 | J:203040 | View | ||||
| Dravet syndrome | Scn1atm1Wac/Scn1a+ | B6.129-Scn1atm1Wac | J:113149, J:188126 | View | ||||
| Dravet syndrome | Scn1atm1Wac/Scn1a+ | involves: 129S1/Sv * 129X1/SvJ * FVB/NJ | J:129998 | View | ||||
| Dravet syndrome |
Scn1atm2.1Kzy/Scn1a+ Tg(Pvalb-cre)1Tama/0 |
involves: 129P2/OlaHsd * C57BL/6 * DBA | J:202863 | View | ||||
| Dravet syndrome |
Scn1atm2.1Kzy/Scn1atm2.1Kzy Tg(Pvalb-cre)1Tama/0 |
involves: 129P2/OlaHsd * C57BL/6 * DBA | J:202863 | View | ||||
| Dravet syndrome |
Scn1atm2.1Wac/Scn1a+ Tg(I12b-cre)1Jlr/0 |
involves: 129X1/SvJ * C57BL/6J | J:188126 | View | ||||
| Dravet syndrome |
Scn1atm2.1Wac/Scn1a+ Tg(I12b-cre)1Jlr/0 |
involves: C57BL/6J * CD-1 | J:189897 | View | ||||
| familial temporal lobe epilepsy 1 | Lgi1tm1.1Ics/Lgi1tm1.1Ics | involves: 129S2/SvPas * BALB/c * C57BL/6 | J:182795 | View | ||||
| familial temporal lobe epilepsy 1 |
Lgi1tm1.1Jkc/Lgi1tm1.1Jkc Tyrc-Brd/Tyrc-Brd |
B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc | J:158715 | View | ||||
| familial temporal lobe epilepsy 1 | Lgi1tm1Mafu/Lgi1tm1Mafu | involves: 129S6/SvEvTac * C57BL/6 | J:157578 | View | ||||
| familial temporal lobe epilepsy 1 | Tg(Lgi1*)#Mpan/0 | Not Specified | J:154129 | View | ||||
| generalized epilepsy with febrile seizures plus |
Kcnq2Nmf134/Kcnq2+ Scn1atm1.1Aesc/Scn1a+ |
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J | J:170734 | View | ||||
| generalized epilepsy with febrile seizures plus | Scn1atm1.1Aesc/Scn1a+ | involves: 129X1/SvJ * C57BL/6J * SJL | J:161191 | View | ||||
| generalized epilepsy with febrile seizures plus |
Scn1atm1.1Aesc/Scn1a+ Tg(Eno2-Scn2a1*)Q54Mm/0 |
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * SJL/J | J:170734 | View | ||||
| generalized epilepsy with febrile seizures plus | Scn1atm1.1Aesc/Scn1atm1.1Aesc | involves: 129X1/SvJ * C57BL/6J * SJL | J:161191 | View | ||||
| generalized epilepsy with febrile seizures plus | Tg(Scn1a*)RH9Aesc/0 | involves: FVB/NJ | J:150454 | View | ||||
| juvenile myoclonic epilepsy | Efhc1tm1Kzy/Efhc1+ | B6.129P2-Efhc1tm1Kzy | J:145858 | View | ||||
| juvenile myoclonic epilepsy | Efhc1tm1Kzy/Efhc1tm1Kzy | B6.129P2-Efhc1tm1Kzy | J:145858 | View | ||||
| progressive myoclonus epilepsy 1B | Prickle1em1Yzou/Prickle1+ | C57BL/6-Prickle1em1Yzou | J:321396 | View | ||||
| Unverricht-Lundborg syndrome | Cstbtm1Rm/Cstbtm1Rm | either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) | J:50587, J:71823 | View | ||||
| | childhood electroclinical syndrome | Cacna1atg/Cacna1atg | B6.D2-Cacna1atg/J | J:6154 | View | |||
| early infantile epileptic encephalopathy | Arxtm1.1Ics/Y | involves: 129S2/SvPas * C57BL/6J * C57BL/6N | J:262482 | View | ||||
| early infantile epileptic encephalopathy | Arxtm1.1Jno/Y | involves: 129S7/SvEvBrd * C57BL/6J | J:151082 | View | ||||
| early infantile epileptic encephalopathy |
Arxtm1Gldn/Arx+ Tg(mI56i-cre,EGFP)1Kc/0 |
involves: 129/Sv * C57BL/6 * CD-1 * FVB/N | J:148311 | View | ||||
| early infantile epileptic encephalopathy |
Arxtm1Gldn/Y Tg(mI56i-cre,EGFP)1Kc/0 |
involves: 129/Sv * C57BL/6 * CD-1 * FVB/N | J:148311 | View | ||||
| early infantile epileptic encephalopathy | Arxtm4Kki/Y | involves: 129S/SvEv * C57BL/6J | J:197588 | View | ||||
| early infantile epileptic encephalopathy | Arxtm4Kki/Y | involves: 129S/SvEv * C57BL/6NHsd | J:260340 | View | ||||
| early infantile epileptic encephalopathy | Arxtm5Kki/Y | involves: 129S/SvEv * C57BL/6NHsd | J:260340 | View | ||||
| early infantile epileptic encephalopathy | Got2em2Pcamp/Got2em2Pcamp | involves: C57BL/6 | J:291216 | View | ||||
| early infantile epileptic encephalopathy | Got2em3Pcamp/Got2em3Pcamp | involves: C57BL/6 | J:291216 | View | ||||
| early infantile epileptic encephalopathy | Scn8aem1Mm/Scn8a+ | involves: C57BL/6J * SJL | J:207931 | View | ||||
| epilepsy | Aldh5a1tm1Kmg/Aldh5a1tm1Kmg | involves: 129/Sv * C57BL/6 | J:91856 | View | ||||
| epilepsy | Atp6v1b2em1Pcamp/Atp6v1b2em1Pcamp | C57BL/6N-Atp6v1b2em1Pcamp | J:342781 | View | ||||
| epilepsy | Bsntm1Gund/Bsntm1Gund | Not Specified | J:82241 | View | ||||
| epilepsy | C1qatm1Mjw/C1qatm1Mjw | involves: 129S/SvEv | J:159281 | View | ||||
| epilepsy | Cacna2d2du-2J/Cacna2d2du-2J | involves: C57BL/6 * C57BLKS/J | J:213548 | View | ||||
| epilepsy |
Cdyltm1.1Yuw/Cdyltm1.1Yuw Emx1tm1(cre)Yql/Emx1+ |
involves: 129S2/SvPas * C57BL/6 | J:251551 | View | ||||
| epilepsy | Gad2tm1Bae/Gad2tm1Bae | involves: 129X1/SvJ * NOD | J:44638 | View | ||||
| epilepsy | Kcna1tm1Tem/Kcna1tm1Tem | involves: 129S7/SvEvBrd | J:164091 | View | ||||
| epilepsy | Scamp5tm1Smoc/Scamp5tm1Smoc | involves: C57BL/6J | J:288324 | View | ||||
| epilepsy | Scn8a8J/Scn8a+ | involves: C3HeB/FeJ * C57BL/6J | J:147199, J:212131 | View | ||||
| epilepsy | Slc12a5tm1Dlp/Slc12a5+ | involves: C57BL/6J | J:113307 | View | ||||
| epilepsy |
Syn1tm1Pggd/Syn1tm1Pggd Syn2tm1Pggd/Syn2tm1Pggd Syn3tm1Pggd/Syn3tm1Pggd |
involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6 | J:175256 | View | ||||
| epilepsy | Syn2tm1Pggd/Syn2tm1Pggd | Not Specified | J:202031 | View | ||||
| generalized epilepsy with febrile seizures plus | Gabrg2tm1.2Rmac/Gabrg2+ | involves: C57BL/6 * C57BL/6J * SJL | J:306976 | View | ||||
| generalized epilepsy with febrile seizures plus | Scn1btm1.1Bion/Scn1b+ | Not Specified | J:163771 | View | ||||
| idiopathic generalized epilepsy | Dnm1Ftfl/Dnm1Ftfl | C57BL/6J-Dnm1Ftfl | J:163311 | View | ||||
| idiopathic generalized epilepsy | Dnm1Ftfl/Dnm1tm1.2Frk | involves: 129 * C57BL/6J * FVB | J:235711 | View | ||||
| idiopathic generalized epilepsy | Gabra1tm1.1Geh/Gabra1+ | B6.129(Cg)-Gabra1tm1.1Geh | J:186685, J:227437 | View | ||||
| idiopathic generalized epilepsy | Gabra1tm1.1Geh/Gabra1+ | D2.129(Cg)-Gabra1tm1.1Geh | J:186685 | View | ||||
| idiopathic generalized epilepsy | Gabra1tm1.1Mjga/Gabra1+ | B6J.Cg-Gabra1tm1.1Mjga | J:227437 | View | ||||
| Lafora disease | Epm2atm1Kzy/Epm2atm1Kzy | involves: 129P2/OlaHsd * C57BL/6J | J:76688, J:173769 | View | ||||
| Lafora disease | Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg | involves: C57BL/6J * C57BL/6NTac | J:165994, J:218959 | View | ||||
| Lafora disease | Nhlrc1tm1.2Geno/Nhlrc1tm1.2Geno | involves: 129S2/SvPas * C57BL/6J | J:181559 | View | ||||
| Lafora disease | Nhlrc1tm1Bmin/Nhlrc1tm1Bmin | involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr | J:181674 | View | ||||
| Lennox-Gastaut syndrome | DgkdGt(RRT600)Byg/DgkdGt(RRT600)Byg | involves: 129P2/OlaHsd * C57BL/6 | J:126380 | View | ||||
| progressive myoclonus epilepsy | Scarb2tm1Psa/Scarb2tm1Psa | involves: 129P2/OlaHsd * C57BL/6N | J:216676 | View | ||||
| pyridoxine-dependent epilepsy | Aldh7a1tm1d(EUCOMM)Hmgu/Aldh7a1tm1d(EUCOMM)Hmgu | B6(FVB)-Aldh7a1tm1d(EUCOMM)Hmgu | J:298561 | View | ||||
| temporal lobe epilepsy |
Glultm1.1Ncd/Glultm1.1Ncd Emx1tm1(cre)Krj/Emx1+ |
B6.Cg-Glultm1.1Ncd Emx1tm1(cre)Krj | J:272643 | View | ||||
| temporal lobe epilepsy | Kcna1tm1Tem/Kcna1tm1Tem | C3Fe.129S7-Kcna1tm1Tem | J:206598 | View | ||||
| temporal lobe epilepsy | Slc32a1tm2(cre)Lowl/Slc32a1tm2(cre)Lowl | either: B6J.129S6(FVB)-Slc32a1tm2(cre)Lowl or (involves: 129S6/SvEvTac * C57BL/6J * FVB/N) | J:308516 | View | ||||
| Transgenes and Other Mutations | epilepsy |
Kcnq2Nmf134/Kcnq2+ Tg(Eno2-Scn2a1*)Q54Mm/0 |
involves: C57BL/6J * SJL/J | J:136510 | View | |||
| epilepsy |
Szt1/Szt1+ Tg(Eno2-Scn2a1*)Q54Mm/0 |
involves: C57BL/6J * SJL/J | J:136510 | View | ||||
| epilepsy | Tg(Camk2a-Bdnf)A9Stl/0 | C57BL/6-Tg(Camk2a-Bdnf)A9Stl/J | J:216846 | View | ||||
| epilepsy | Tg(Eno2-Scn2a1*)Q54Mm/0 | B6.Cg-Tg(Eno2-Scn2a1*)Q54Mm | J:136510 | View | ||||
| epilepsy | Tg(RP23-65I14)1Jno/? | involves: FVB | J:146431 | View | ||||
| epilepsy | Tg(RP23-65I14)2Jno/? | involves: FVB/N | J:146431 | View | ||||
| Lafora disease | Tg(CAG-EPM2A*C266S)1Bmin/0 | involves: 129 * C57BL/6 * SJL | J:262504, J:120356 | View | ||||
| Additional Complex Models | epilepsy |
Gng3tm1.1Rbs/Gng3tm1.1Rbs Gng7tm1Lex/Gng7tm1Lex |
B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs | J:182775 | View | |||
| idiopathic generalized epilepsy | Cacna2d2du/Cacna2d2du | TKDU/DnJ | J:70845 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | autosomal dominant nocturnal frontal lobe epilepsy 1 | Chrna4tm1Dra/Chrna4tm1Dra | involves: 129S4/SvJae * C57BL/6 | J:64208, J:97020 | View | |||
| developmental and epileptic encephalopathy | Pigkem1Linwu/Pigkem1Linwu | involves: C57BL/6J | J:305399 | View | ||||
| developmental and epileptic encephalopathy | Pigkem2Linwu/Pigkem2Linwu | involves: C57BL/6J | J:305399 | View | ||||
| developmental and epileptic encephalopathy 14 | Kcnt1em1Pqt/Kcnt1+ | C57BL/6J-Kcnt1em1Pqt | J:333512 | View | ||||