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All mouse models of optic nerve disease with phenotypic similarity to the human disease
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Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
Leber hereditary optic neuropathy | mt-Nd6m3Dwa | B6.129S-mt-Nd6m3Dwa | J:192260 | View | ||||
optic atrophy | Opa1M1Bewi/Opa1+ | involves: C3HeB/FeJ * C57BL/6 | J:154966 | View | ||||
optic atrophy | Opa1Q285X/Opa1+ | involves: C3HeB/FeJ * C57BL/6JCrl | J:121779, J:189276 | View | ||||
optic atrophy | Opa1tm1.1Geno/Opa1+ | involves: 129S2/SvPas | J:237963 | View | ||||
optic atrophy | Rpl24Bst/Rpl24+ | involves: C57BLKS | J:28035 | View | ||||
Transgenes and Other Mutations | Leber hereditary optic neuropathy | Tg(LONP1-mt-ND4*,-mCherry*)#Jguy | B6(D2)-Tg(LONP1-mt-ND4*,-mCherry*)#Jguy | J:224897 | View | |||
Additional Complex Models | optic atrophy |
Fdxrm1J/Fdxrm1J Otop2m1J/Otop2m1J |
B6;129S-Fdxrm1J Otop2m1J/GrsrJ | J:247931 | View |