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All mouse models of dysostosis with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | acrocephalosyndactylia |
Fgfr2tm1Ewj/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N | J:101174, J:156940 | View | |||
| acrocephalosyndactylia | Fgfr2tm2.3Dsn/Fgfr2+ | involves: 129 * C57BL/6 * FVB/N | J:72517 | View | ||||
| acrocephalosyndactylia |
Fgfr2tm2Cxd/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 |
involves: 129S6/SvEvTac * C57BL/6J * FVB/N | J:228708 | View | ||||
| acrocephalosyndactylia |
Fgfr2tm2Cxd/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 |
involves: 129S6/SvEvTac * FVB/N | J:101385 | View | ||||
| acrocephalosyndactylia | Fgfr2tm2Ewj/Fgfr2+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:156940 | View | ||||
| acrocephalosyndactylia |
Fgfr2tm2Ewj/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 |
B6.Cg-Fgfr2tm2Ewj Tg(EIIa-cre)C5379Lmgd | J:158773 | View | ||||
| acrocephalosyndactylia | Fgfr2tm3.1Cxd/Fgfr2+ | involves: 129S6/SvEvTac * FVB/N | J:283626 | View | ||||
| acrocephalosyndactylia |
Fgfr2tm3Cxd/Fgfr2+ Tg(Col2a1-cre)1Xya/0 |
involves: 129S6/SvEvTac * C57BL/6J | J:286452 | View | ||||
| acrodysostosis | Prkar1atm1.1Geno/Prkar1a+ | involves: C57BL/6J | J:303060 | View | ||||
| brachydactyly type A1 | Ihhtm1.1Dcha/Ihhtm1.1Dcha | either: (involves: 129S/SvEv * FVB/N) or (involves: 129S/SvEv * FVB/N * ICR) | J:147878 | View | ||||
| brachydactyly type A1C | Gdf5Bp-5J/Gdf5+ | C57BL/6J-Gdf5Bp-5J/GrsrJ | J:200816 | View | ||||
| brachydactyly type A2 | Gdf5Bp-5J/Gdf5+ | C57BL/6J-Gdf5Bp-5J/GrsrJ | J:200816 | View | ||||
| brachydactyly type C | Gdf5Bp-5J/Gdf5+ | C57BL/6J-Gdf5Bp-5J/GrsrJ | J:200816 | View | ||||
| Carpenter syndrome | Megf8b2b288Clo/Megf8b2b288Clo | C57BL/6J-Megf8b2b288Clo | J:175213 | View | ||||
| Carpenter syndrome | Megf8b2b1702.2Clo/Megf8b2b1702.2Clo | C57BL/6J-Megf8b2b1702.2Clo | J:175213 | View | ||||
| craniosynostosis | Tg(CMV-Msx2*P7H)1Rem/0 | involves: C57BL/6 * CBA/J | J:26513 | View | ||||
| craniosynostosis | Tg(Msx2)1Rem/0 | involves: C57BL/6 * CBA/J | J:26513 | View | ||||
| craniosynostosis | Tg(Timp1-Msx2*P7H)1Rem/0 | involves: C57BL/6 * CBA/J | J:26513 | View | ||||
| Crouzon syndrome | Fgfr2m1Sgg/Fgfr2+ | involves: C3H/HeJ * C57BL/6J | J:160674 | View | ||||
| Crouzon syndrome | Fgfr2m1Sgg/Fgfr2m1Sgg | involves: C3H/HeJ * C57BL/6J | J:160674 | View | ||||
| Crouzon syndrome | Fgfr2tm1Schl/Fgfr2+ | involves: 129S1/Sv | J:118299 | View | ||||
| Crouzon syndrome | Fgfr2tm4Lni/Fgfr2+ | Not Specified | J:92433, J:235329 | View | ||||
| Greig cephalopolysyndactyly syndrome | Gli3Xt-J/Gli3Xt-J | involves: C3H * CD-1 | J:4086 | View | ||||
| Muenke Syndrome | Fgfr3tm1.1Aomw/Fgfr3+ | 129S6.129P2-Fgfr3tm1.1Aomw | J:144356 | View | ||||
| Muenke Syndrome | Fgfr3tm1.1Aomw/Fgfr3+ | B6.129P2-Fgfr3tm1.1Aomw | J:144356 | View | ||||
| Muenke Syndrome | Fgfr3tm1.1Aomw/Fgfr3+ | CBACa.129P2-Fgfr3tm1.1Aomw | J:144356 | View | ||||
| Muenke Syndrome | Fgfr3tm1.1Aomw/Fgfr3tm1.1Aomw | 129S6.129P2-Fgfr3tm1.1Aomw | J:144356 | View | ||||
| Muenke Syndrome | Fgfr3tm1.1Aomw/Fgfr3tm1.1Aomw | B6.129P2-Fgfr3tm1.1Aomw | J:144356 | View | ||||
| Muenke Syndrome | Fgfr3tm1.1Aomw/Fgfr3tm1.1Aomw | CBACa.129P2-Fgfr3tm1.1Aomw | J:144356 | View | ||||
| Pfeiffer syndrome | Fgfr1tm1Led/Fgfr1tm1Led | involves: 129S4/SvJae * NIH Black Swiss | J:22118 | View | ||||
| Pfeiffer syndrome | Fgfr1tm2.1Cxd/Fgfr1+ | D2.129S6(Cg)-Fgfr1tm2.1Cxd | J:228708 | View | ||||
| Pfeiffer syndrome | Fgfr2tm2.3Dsn/Fgfr2+ | involves: 129 * C57BL/6 * FVB/N | J:72517 | View | ||||
| Saethre-Chotzen syndrome |
Msx2tm1Rilm/Msx2+ Twist1tm1Bhr/Twist1+ |
involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/c * C57BL/6 | J:87044 | View | ||||
| Saethre-Chotzen syndrome | Twist1Pas/Twist1+ | involves: C57BL/6 * PDT/Pas | J:86815 | View | ||||
| Saethre-Chotzen syndrome | Twist1Pas/Twist1Pas | involves: C57BL/6 * PDT/Pas | J:86815 | View | ||||
| Saethre-Chotzen syndrome | Twist1Pde/Twist1+ | involves: 129S1/Sv * C57BL/6J | J:69450 | View | ||||
| Saethre-Chotzen syndrome | Twist1Pde/Twist1Pde | involves: 129S1/Sv * C57BL/6J | J:69450 | View | ||||
| Saethre-Chotzen syndrome | Twist1tm1Bhr/Twist1+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:79294 | View | ||||
| Saethre-Chotzen syndrome | Twist1tm1Bhr/Twist1+ | involves: 129S7/SvEvBrd * C57BL/6 | J:44379 | View | ||||
| Saethre-Chotzen syndrome | Twist1tm1Bhr/Twist1tm1Bhr | involves: 129S7/SvEvBrd * C57BL/6 | J:44379 | View | ||||
| | craniosynostosis | Axin2tm1Wbm/Axin2tm1Wbm | involves: 129P2/OlaHsd * C57BL/6 | J:98523 | View | |||
| Crouzon syndrome | Bey/Bey+ | 129S/SvEv-Bey | J:47965 | View | ||||
| dysostosis |
Kif3atm2Gsn/Kif3atm2Gsn H2az2Tg(Wnt1-cre)11Rth/H2az2+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J | J:158523 | View | ||||
| multiple synostoses syndrome | Fgf9tm1Zgwg/Fgf9+ | involves: 129S1/Sv | J:241783 | View | ||||
| multiple synostoses syndrome | Fgf9tm1Zgwg/Fgf9tm1Zgwg | involves: 129S1/Sv | J:241783 | View | ||||
| multiple synostoses syndrome | Gdf5Bp-5J/Gdf5+ | C57BL/6J-Gdf5Bp-5J/GrsrJ | J:200816 | View | ||||
| spondylocostal dysostosis | Dll3tm1Rbe/Dll3tm1Rbe | involves: 129P2/Ola * C57BL/6 | J:75954 | View | ||||
| spondylocostal dysostosis | Hes7M1Btlr/Hes7+ | C57BL/6J-Hes7M1Btlr | J:307652 | View | ||||
| spondylocostal dysostosis | Ripply2tm1Asas/Ripply2tm1Asas | involves: C57BL/6 * CBA | J:122747 | View | ||||
| syndactyly | b2b1594Clo/b2b1594Clo | C57BL/6J-b2b1594Clo | J:175213 | View | ||||
| synpolydactyly | Hoxd13spdh/Hoxd13spdh | B6C3Fe a/a-Hoxd13spdh/J | J:47974 | View | ||||
| synpolydactyly | Hoxd13tm1Ddu/Hoxd13tm1Ddu | either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6) | J:15507 | View | ||||
| synpolydactyly | Hoxd13tm1Mrc/Hoxd13tm1Mrc | involves: 129S7/SvEvBrd | J:32603 | View | ||||
| Transgenes and Other Mutations | craniosynostosis | Tg(Nell1)1Ting/0 | involves: C3H * C57BL/6 | J:79106 | View | |||
| Additional Complex Models | acrocephalosyndactylia |
Spry2tm1Ayos/Spry2tm1Ayos Spry4tm1Ayos/Spry4tm1Ayos |
involves: 129 * C57BL/6J | J:116506 | View | |||
| brachydactyly type A1 | ShhDsh/Shh+ | B10Rl.Cg-ShhDsh | J:97323 | View | ||||
| spondylocostal dysostosis | Tbx6rv/Tbx6rv | involves: C57BL/J * C57BL/6J | J:8119 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | brachydactyly type B1 | Ror2tm1Anec/Ror2+ | B6.129S1-Ror2tm1Anec | J:134490 | View | |||