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All mouse models of gonadal disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | 17-beta hydroxysteroid dehydrogenase 3 deficiency | Hsd17b3tm1.2Mpo/Hsd17b3tm1.2Mpo | involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NCrl | J:301756 | View | |||
| 46,XY sex reversal | Dhhtm1Amc/Dhhtm1Amc | involves: 129S1/Sv * C57BL/6J * Swiss Webster | J:65900 | View | ||||
| androgen insensitivity syndrome | ArTfm/Y | involves: NMRI * STOCK EdaTa Atp7aMo-blo | J:140803 | View | ||||
| androgen insensitivity syndrome | ArTfm/Y | involves: STOCK EdaTa Atp7aMo-blo | J:140803 | View | ||||
| androgen insensitivity syndrome | ArTfm/Y | STOCK EdaTa Atp7aMo-blo/+ + | J:5173 | View | ||||
| androgen insensitivity syndrome |
ArTfm/Y Tg(TSPY)9Jshm/0 |
involves: NMRI * STOCK EdaTa Atp7aMo-blo | J:140803 | View | ||||
| androgen insensitivity syndrome | Artm1.1Jdz/Y | B6.129X1-Artm1.1Jdz | J:123057 | View | ||||
| androgen insensitivity syndrome | Artm1.1Jdz/Y | involves: 129X1/SvJ * C57BL/6 | J:122327 | View | ||||
| androgen insensitivity syndrome | Artm1.1Verh/Y | involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 | J:88169 | View | ||||
| androgen insensitivity syndrome |
Artm1Ska/Y Tg(CMV-cre)1Ipc/? |
involves: C57BL/6 * CBA | J:85484 | View | ||||
| cryptorchidism |
ArTfm/Y Insl3tm1Imad/Insl3tm1Imad |
involves: 129/Sv * CD-1 * STOCK EdaTa | J:83429 | View | ||||
| cryptorchidism | Insl3tm1Imad/Insl3tm1Imad | involves: 129 | J:83429 | View | ||||
| cryptorchidism | Insl3tm1Imad/Insl3tm1Imad | involves: 129/Sv * CD-1 | J:83429 | View | ||||
| cryptorchidism | Insl3tm1Par/Insl3+ | involves: 129/Sv * CD-1 | J:55881 | View | ||||
| cryptorchidism | Insl3tm1Par/Insl3tm1Par | involves: 129/Sv * CD-1 | J:55881 | View | ||||
| hypogonadotropic hypogonadism 7 with or without anosmia | Gnrhrhh/Gnrhrhh | involves: 129S6/SvEvTac * C57BL/6 | J:96941 | View | ||||
| hypogonadotropic hypogonadism 8 with or without anosmia | Kiss1rtm1.1Lex/Kiss1rtm1.1Lex | involves: 129S4/SvJae | J:181650 | View | ||||
| hypogonadotropic hypogonadism 8 with or without anosmia | Kiss1rtm1Coll/Kiss1rtm1Coll | involves: 129S6/SvEvTac | J:96442 | View | ||||
| hypogonadotropic hypogonadism 8 with or without anosmia | Kiss1rtm1Gstn/Kiss1rtm1Gstn | involves: 129P2/OlaHsd | J:102113 | View | ||||
| hypogonadotropic hypogonadism 8 with or without anosmia | Kiss1rtm1Rla/Kiss1rtm1Rla | involves: 129S1/SvImJ | J:126704 | View | ||||
| hypogonadotropic hypogonadism 11 with or without anosmia | Tacr3tm1Jasi/Tacr3tm1Jasi | involves: 129P2/OlaHsd * C57BL/6 | J:182547 | View | ||||
| hypogonadotropic hypogonadism 12 with or without anosmia | Gnrh1hpg/Gnrh1hpg | involves: 101/H * C3H/HeH | J:5877 | View | ||||
| hypogonadotropic hypogonadism 13 with or without anosmia | Kiss1tm1Coll/Kiss1tm1Coll | involves: 129S/SvEv * 129S6/SvEvTac | J:122381 | View | ||||
| hypogonadotropic hypogonadism 13 with or without anosmia | Kiss1tm1Rla/Kiss1tm1Rla | involves: 129S1/SvImJ | J:126704 | View | ||||
| Kallmann syndrome | Sox10tm1Weg/Sox10tm1Weg | involves: 129S1/Sv * 129X1/SvJ | J:203636 | View | ||||
| ovarian cancer |
Amhr2tm3(cre)Bhr/Amhr2+ Ctnnb1tm1Mmt/Ctnnb1+ |
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 | J:186144 | View | ||||
| ovarian cancer |
Amhr2tm3(cre)Bhr/Amhr2+ Ctnnb1tm1Mmt/Ctnnb1+ Ptentm1Hwu/Ptentm1Hwu |
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 | J:186144 | View | ||||
| ovarian cancer |
Ctnnb1tm1Mmt/Ctnnb1+ Krastm4Tyj/Kras+ Amhr2tm3(cre)Bhr/Amhr2+ |
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 | J:186144 | View | ||||
| ovarian cancer |
Ctnnb1tm1Mmt/Ctnnb1+ Krastm4Tyj/Kras+ Tg(CYP19A1-cre)1Jri/0 |
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 | J:186144 | View | ||||
| ovarian cancer |
Ctnnb1tm1Mmt/Ctnnb1+ Ptentm1Hwu/Ptentm1Hwu Tg(CYP19A1-cre)1Jri/0 |
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 | J:186144 | View | ||||
| ovarian cancer |
Ctnnb1tm1Mmt/Ctnnb1+ Tg(CYP19A1-cre)1Jri/0 |
involves: 129X1/SvJ * C57BL/6 | J:186144 | View | ||||
| persistent Mullerian duct syndrome | Amhr2tm1Bhr/Amhr2tm1Bhr | involves: 129S7/SvEvBrd | J:171430 | View | ||||
| primary ovarian insufficiency 12 | Syce1em1Rrca/Syce1em1Rrca | involves: C57BL/6J | J:309952 | View | ||||
| primary ovarian insufficiency 13 | Msh5em1Jzc/Msh5em1Jzc | involves: C57BL/6 | J:241778 | View | ||||
| primary ovarian insufficiency 19 | Hsf2bpem2Amp/Hsf2bpem2Amp | involves: C57BL/6J * CBA/J | J:303558 | View | ||||
| | 46 XX gonadal dysgenesis | Fanclgcd/Fanclgcd | involves: C57BL/6J * CBA/J | J:13553 | View | |||
| androgen insensitivity syndrome | Fkbp4tm1Dvds/Fkbp4tm1Dvds | involves: 129X1/SvJ * C57BL/6 | J:98554 | View | ||||
| androgen insensitivity syndrome | Fkbp4tm1Shou/Fkbp4tm1Shou | involves: 129S/SvEv | J:120960 | View | ||||
| dermoid cyst of ovary |
Foxo3mommeR1/Foxo3mommeR1 Tg(HBA1-GFP)1Ew/Tg(HBA1-GFP)1Ew |
FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew | J:170710 | View | ||||
| hyperandrogenism | Prl3c1tm1(KOMP)Vlcg/Prl3c1tm1(KOMP)Vlcg | involves: C57BL/6NTac * CD-1 | J:256588 | View | ||||
| hypogonadotropic hypogonadism |
Nr5a1tm2Klp/Nr5a1tm2.1Klp Tg(Cga-cre)3Sac/0 |
involves: 129P2/OlaHsd * C57BL/6J * SJL | J:66593 | View | ||||
| Kallmann syndrome | Wdr11Gt(Ayu21-KBW205)Imeg/Wdr11Gt(Ayu21-KBW205)Imeg | B6.Cg-Wdr11Gt(Ayu21-KBW205)Imeg | J:257035 | View | ||||
| ovarian cancer |
Apctm1Rsmi/Apctm1Rsmi Pgrtm2(cre)Lyd/Pgr+ |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J | J:210095 | View | ||||
| ovarian cancer |
Apctm1Tno/Apctm1Tno Ptentm2Mak/Ptentm2Mak |
involves: 129P2/OlaHsd * 129S4/SvJae | J:120955 | View | ||||
| ovarian disease | Patl2tm1b(EUCOMM)Hmgu/Patl2tm1b(EUCOMM)Hmgu | involves: C57BL/6N * FVB/N | J:264835 | View | ||||
| ovarian hyperstimulation syndrome | Nr1h3tm1Djm/Nr1h3tm1Djm | involves: 129S6/SvEvTac * C57BL/6 | J:158168 | View | ||||
| polycystic ovary syndrome | Akt2tm1Hem/Akt2tm1Hem | involves: 129P2/OlaHsd | J:185012 | View | ||||
| primary ovarian insufficiency | Fancftm1Nki/Fancftm1Nki | involves: 129P2/OlaHsd * FVB | J:180025 | View | ||||
| primary ovarian insufficiency | Polr3hem2Cfe/Polr3hem2Cfe | involves: C57BL/6J * SJL/J | J:290735 | View | ||||
| | cryptorchidism | Rxfp2tm1Aia/crsp | involves: 129S7/SvEvBrd * C57BL/6J * FVB/N | J:79124 | View | |||
| cryptorchidism | Rxfp2tm1Aia/Rxfp2tm1Aia | involves: 129S7/SvEvBrd * C57BL/6J | J:79124 | View | ||||
| ovarian cancer |
Arid1atm1.1Mag/Arid1atm1.1Mag Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ |
involves: 129S6/SvEvTac * CD-1 | J:219794 | View | ||||
| ovarian cancer |
Brca1tm1Brn/Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N | J:189304 | View | ||||
| ovarian cancer |
Brca1tm1Brn/Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53tm1Brn/Trp53tm2Tyj |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N | J:189304 | View | ||||
| ovarian cancer |
Brca2tm1Brn/Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53tm1Brn/Trp53tm2Tyj |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N | J:189304 | View | ||||
| ovarian cancer |
Dicer1tm1Tara/Dicer1tm1Tara Ptentm1Hwu/Ptentm1Hwu Amhr2tm3(cre)Bhr/Amhr2+ |
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd | J:182161 | View | ||||
| ovarian cancer |
Dicer1tm1Tara/Dicer1tm1Tara Ptentm1Hwu/Ptentm1Hwu Trp53tm2Tyj/Trp53+ Amhr2tm3(cre)Bhr/Amhr2+ |
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd | J:222579 | View | ||||
| ovarian cancer |
Krastm4Tyj/Kras+ Ptentm1Hwu/Ptentm1Hwu |
involves: 129S4/SvJae | J:161953 | View | ||||
| ovarian cancer |
Krastm4Tyj/Kras+ Ptentm1Hwu/Ptentm1Hwu |
involves: 129S4/SvJae * C57BL/6J | J:96296 | View | ||||
| ovarian cancer |
Ptentm1Hwu/Ptentm1Hwu Trp53tm2Tyj/Trp53+ Amhr2tm3(cre)Bhr/Amhr2+ |
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd | J:222579 | View | ||||
| Transgenes and Other Mutations | dermoid cyst of ovary | Tg(Amh-SMAD2*)#Jebu/0 | FVB/N-Tg(Amh-SMAD2*)#Jebu | J:200783 | View | |||
| ovarian cancer | Tg(Amhr2-SV40TAg)1Dcco/0 | (C57BL/6 x C3H)F1 | J:82550 | View | ||||
| ovarian cancer | Tg(CAG-lacZ,-SV40)#Bcv/0 | involves: FVB/N | J:158388 | View | ||||
| polycystic ovary syndrome | Tg(Cyp17a1-NGF)2456Oje/Tg(Cyp17a1-NGF)2456Oje | involves: C57BL/6J * DBA/2J | J:218686 | View | ||||
| Additional Complex Models | ovarian cancer |
Amhr2tm3(cre)Bhr/Amhr2+ Smad1tm2Rob/Smad1tm2.1Rob Smad5tm1Huy/Smad5tm1Huy |
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J | J:157310 | View | |||
| ovarian cancer |
Amhr2tm3(cre)Bhr/Amhr2+ Smad1tm2Rob/Smad1tm2Rob Smad5tm1Huy/Smad5tm1Huy |
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J | J:157310 | View | ||||
| ovarian cancer |
Amhr2tm3(cre)Bhr/Amhr2+ Smad1tm2Rob/Smad1tm2Rob Smad5tm1Huy/Smad5tm1Zuk |
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J | J:157310 | View | ||||
| ovarian cancer |
Cdkn1btm1Ako/Cdkn1b+ KitW-v/KitW-v |
involves: 129S1/Sv * C57BL/6J | J:236161 | View | ||||
| ovarian cancer |
Cdkn1btm1Ako/Cdkn1btm1Ako KitW-v/KitW-v |
involves: 129S1/Sv * C57BL/6J | J:236161 | View | ||||
| ovarian cancer |
Foxo1tm1Rdp/Foxo1tm1.1Rdp Foxo3tm1Rdp/Foxo3tm1.1Rdp Amhr2tm3(cre)Bhr/Amhr2+ |
involves: 129S6/SvEvTac * 129S7/SvEvBrd | J:232961 | View | ||||
| ovarian cancer |
Foxo1tm1Rdp/Foxo1tm1.1Rdp Foxo3tm1Rdp/Foxo3tm1.1Rdp Tg(CYP19A1-cre)1Jri/0 |
involves: 129S6/SvEvTac | J:232961 | View | ||||
| ovarian cancer |
KitW-v/KitW-v Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * C57BL/6J * FVB/N | J:236161 | View | ||||
| ovarian cancer |
Rb1tm2Brn/Rb1tm2Brn Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd | J:84345 | View | ||||
| ovarian cancer |
Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N | J:189304 | View | ||||
| ovarian cancer |
Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53tm1Brn/Trp53tm2Tyj |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N | J:189304 | View | ||||
| polycystic ovary syndrome |
Insrtm1Khn/Insrtm1Khn Leprtm1.1Chua/Leprtm1.1Chua Tg(Pomc1-cre)16Lowl/0 |
involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N | J:192274 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | androgen insensitivity syndrome | Artm4(AR)Dmr/Y | involves: 129S1/Sv * C57BL/6J | J:104360 | View | |||
| Kallmann syndrome | Nsmftm1.2Mrkr/Nsmftm1.2Mrkr | involves: C57BL/6 * C57BL/6J | J:232404 | View | ||||
| ovarian cancer | Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 | involves: C3H * C57BL/6 | J:144834 | View | ||||
| primary ovarian insufficiency | Helqem1Eljt/Helqem1Eljt | C57BL/6J-Helqem1Eljt | J:347863 | View | ||||