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All mouse models of obstructive lung disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
 | pulmonary emphysema | Bloc1s6pa/Bloc1s6pa | B6.Cg-Bloc1s6pa/J | J:4098 | View | |||
| pulmonary emphysema | Fstl1tm1Ajn/Fstl1tm1Ajn | B6.Cg-Fstl1tm1Ajn | J:322116 | View | ||||
| pulmonary emphysema | Fut8tm1Nta/Fut8tm1Nta | involves: 129S2/SvPas | J:102932 | View | ||||
| pulmonary emphysema |
Gli2tm1(cre/ERT2)Tipe/Gli2+ Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ |
involves: 129X1/SvJ | J:264185 | View | ||||
| pulmonary emphysema | Itgb6tm1Des/Itgb6tm1Des | involves: 129T2/SvEms | J:89578 | View | ||||
| pulmonary emphysema |
Juntm4Wag/Juntm4Wag Tg(Sftpc-cre)1Blh/0 |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 | J:179883 | View | ||||
| pulmonary emphysema | Klkl/Klkl | either: C.Cg-Klkl or (involves: C3H/HeJ * C57BL/6J) | J:44109 | View | ||||
| pulmonary emphysema | Mus81tm1Esse/Mus81tm1Esse | involves: 129P2/OlaHsd * C57BL/6J | J:222498 | View | ||||
| pulmonary emphysema | Tg(Actb-Ptma)T12Clwu/0 | involves: FVB/N | J:270215 | View | ||||
| pulmonary emphysema | Tg(Actb-Ptma)T12Clwu/Tg(Actb-Ptma)T12Clwu | involves: FVB/N | J:270215 | View | ||||
| pulmonary emphysema | Tlr4tm1Aki/Tlr4tm1Aki | B6.129P2-Tlr4tm1Aki | J:114985 | View | ||||
 | pulmonary emphysema |
Fbn1Tsk/Fbn1+ Tgfb1tm1N/Tgfb1+ |
involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2 | J:68448 | View | |||
| pulmonary emphysema | Serpina1em1Chmu/Serpina1em1Chmu | involves: C57BL/6J | J:259615 | View | ||||
| pulmonary emphysema | Serpina1em2Chmu/Serpina1em2Chmu | involves: C57BL/6J | J:259615 | View | ||||
| pulmonary emphysema | Serpina1em3Chmu/Serpina1em3Chmu | involves: C57BL/6J | J:259615 | View | ||||
| pulmonary emphysema | Serpina1em#Chmu/Serpina1em#Chmu | involves: C57BL/6J | J:259615 | View | ||||
| Transgenes and Other Mutations | pulmonary emphysema | Tg(HP-MMP1a)34-1Cha/0 | involves: C57BL/6J * CBA/J | J:164058 | View | |||
| pulmonary emphysema | Tg(HP-MMP1a)34-1Cha/Tg(HP-MMP1a)34-1Cha | involves: C57BL/6J * CBA/J | J:164058 | View | ||||
| pulmonary emphysema | Tg(Msr1-MMP9)#Apar/0 | B6.Cg-Tg(Msr1-MMP9)#Apar | J:136830 | View | ||||
| pulmonary emphysema |
Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-PLAGL2)P3Ysy/0 |
involves: FVB/N | J:152422 | View | ||||
| Additional Complex Models | pulmonary emphysema | Fbn1Tsk/Fbn1+ | B6.Cg-Fbn1Tsk | J:30961, J:6566, J:15018, J:1326, J:68448 | View | |||
| pulmonary emphysema |
Fbn1Tsk/Fbn1+ Il4ratm1Sz/Il4ra+ |
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2 | J:68448 | View | ||||
| pulmonary emphysema |
Fbn1Tsk/Fbn1+ Il4ratm1Sz/Il4ratm1Sz |
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2 | J:68448 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | chronic obstructive pulmonary disease | Htr4tm1Comp/Htr4tm1Comp | B6.129S1(129T)-Htr4tm1Comp | J:261502 | View | |||
| pulmonary emphysema |
Itgb6tm1Des/Itgb6tm1Des Mmp12tm1Sds/Mmp12tm1Sds |
involves: 129/Sv * 129T2/SvEms | J:89578 | View | ||||