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All mouse models of congenital nervous system abnormality with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | holoprosencephaly 2 | Six3tm1Gco/Six3tm1Gco | involves: 129S1/Sv | J:81797 | View | |||
| holoprosencephaly 2 |
Six3tm3.1Gco/Six3+ Shhtm1Chg/Shh+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:140315 | View | ||||
| holoprosencephaly 2 |
Six3tm3Gco/Six3tm3Gco Foxg1tm1(cre)Skm/Foxg1+ |
involves: 129S1/Sv * C57BL/6 | J:140315 | View | ||||
| holoprosencephaly 2 | Six3tm4(cre/ERT2)Gco/Six3+ | involves: 129S1/Sv * C57BL/6 | J:140315 | View | ||||
| holoprosencephaly 3 |
Disp1icb/Disp1tm1Amc Shhtm1Amc/Shh+ |
involves: 129X1/SvJ * C57BL/6J | J:92058 | View | ||||
| holoprosencephaly 3 | Shhtm1Chg/Shhtm1Chg | involves: 129S1/Sv * 129X1/SvJ | J:35802 | View | ||||
| holoprosencephaly 3 | Shhtm1Chg/Shhtm1Chg | involves: C57BL/6 | J:89364 | View | ||||
| holoprosencephaly 5 | Zic2Ku/Zic2Ku | 129S.CAnNCrl(C3)-Zic2Ku | J:238567 | View | ||||
| holoprosencephaly 5 | Zic2Ku/Zic2Ku | C3.CAnNCrl-Zic2Ku | J:138862 | View | ||||
| holoprosencephaly 5 | Zic2tm1Jaru/Zic2tm1Jaru | involves: 129S4/SvJae * C57BL/6 | J:60644 | View | ||||
| holoprosencephaly 11 |
Boctm1Rsk/Boc+ Cdontm1Rsk/Cdontm1Rsk |
involves: 129/Sv * 129S6/SvEvTac | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm1Rsk/Boctm1Rsk Cdontm1Rsk/Cdontm1Rsk |
B6.129-Boctm1Rsk Cdontm1Rsk | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm1Rsk/Boctm1Rsk Cdontm1Rsk/Cdontm1Rsk |
involves: 129/Sv * 129S6/SvEvTac | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm2Rsk/Boc+ Cdontm1Rsk/Cdontm1Rsk |
involves: 129/Sv * 129S6/SvEvTac | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm2Rsk/Boctm2Rsk Cdontm1Rsk/Cdontm1Rsk |
B6.129-Boctm2Rsk Cdontm1Rsk | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm2Rsk/Boctm2Rsk Cdontm1Rsk/Cdontm1Rsk |
involves: 129/Sv * 129S6/SvEvTac | J:171767 | View | ||||
| holoprosencephaly 11 | Cdontm1Rsk/Cdontm1Rsk | involves: 129/Sv * C57BL/6 | J:82221 | View | ||||
| holoprosencephaly 11 | Cdontm2Rsk/Cdontm2Rsk | involves: 129/Sv * C57BL/6 | J:82221 | View | ||||
| lissencephaly | Pafah1b1tm1Awb/Pafah1b1+ | involves: 129S6/SvEvTac * NIH Black Swiss | J:49531, J:59817 | View | ||||
| lissencephaly |
Pafah1b1tm1Awb/Pafah1b1+ Ywhaetm1Awb/Ywhae+ |
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss) | J:84075 | View | ||||
| lissencephaly | Pafah1b1tm1Awb/Pafah1b1tm2Awb | involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss | J:49531 | View | ||||
| lissencephaly | Pafah1b1tm1Or/Pafah1b1+ | Not Specified | J:69631 | View | ||||
| lissencephaly | Pafah1b1tm2.2Awb/Pafah1b1+ | involves: 129S6/SvEvTac * NIH Black Swiss | J:49531 | View | ||||
| lissencephaly | Tuba1aJna/Tuba1a+ | involves: BALB/cAnN * C3H/HeH | J:117881 | View | ||||
| microcephaly | AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi | involves: 129P2/OlaHsd * C57BL/6JOlaHsd | J:164424 | View | ||||
| microcephaly | AspmGt(AJ0069)Wtsi/AspmGt(AJ0069)Wtsi | involves: 129P2/OlaHsd * C57BL/6JOlaHsd | J:164424 | View | ||||
| microcephaly | Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc | Not Specified | J:228026 | View | ||||
| microcephaly | Cdk5rap2an/Cdk5rap2an | B6.Cg-Cdk5rap2an | J:160533 | View | ||||
| microcephaly |
Cdk5rap2an/Cdk5rap2an Tyrp1B-lt/Tyrp1B-lt |
WBB6F1 | J:160533 | View | ||||
| microcephaly | Mcph1Gt(RRO608)Byg/Mcph1Gt(RRO608)Byg | involves: 129P2/OlaHsd * C57BL/6 | J:157993 | View | ||||
| periventricular nodular heterotopia | FlnaDilp2/Y | involves: BALB/cAnN * C3H/HeN * C57BL/6 | J:112274 | View | ||||
| primary autosomal recessive microcephaly 2 with or without cortical malformations | Wdr62tm1.1Jfch/Wdr62tm1.1Jfch | involves: 129S1/SvImJ * C57BL/6N | J:282438 | View | ||||
| subcortical band heterotopia | Eml1tm1.2Ics/Eml1tm1.2Ics | C57BL/6N-Eml1tm1.2Ics | J:294769 | View | ||||
| subcortical band heterotopia | Eml1tvrm360/Eml1tvrm360 | C57BL/6J-Eml1tvrm360/Pjn | J:297748 | View | ||||
| | anencephaly | Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc | 129P2(C)-Cecr2Gt(pGT1)1Hemc | J:96325 | View | |||
| anencephaly | Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc | C.129P2-Cecr2Gt(pGT1)1Hemc | J:96325 | View | ||||
| anencephaly | Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc | involves: 129P2/OlaHsd * BALB/c | J:96325 | View | ||||
| anencephaly | Efna5tm1Ddmo/Efna5tm1Ddmo | involves: 129S1/Sv * 129X1/SvJ | J:77779 | View | ||||
| anencephaly | Lmo4tm1.1Gng/Lmo4tm1.1Gng | involves: 129X1/SvJ | J:96957 | View | ||||
| chromosome 1q41-q42 deletion syndrome | Trp53bp2tm1Xlu/Trp53bp2tm1Xlu | B6.129S6-Trp53bp2tm1Xlu | J:240594 | View | ||||
| chromosome 1q41-q42 deletion syndrome | Trp53bp2tm1Xlu/Trp53bp2tm1Xlu | C.129S6-Trp53bp2tm1Xlu | J:240594 | View | ||||
| chromosome 1q41-q42 deletion syndrome | Trp53bp2tm1Xlu/Trp53bp2tm1Xlu | involves: 129S6/SvEvTac * C57BL/6J | J:240594 | View | ||||
| congenital nervous system abnormality | Eml1heco/? | involves: CD-1 | J:211342 | View | ||||
| congenital nervous system abnormality | Eml1heco/Eml1heco | involves: C57BL/6 * NOR | J:208031 | View | ||||
| congenital nervous system abnormality | Eml1heco/Eml1heco | involves: NOR | J:208031 | View | ||||
| congenital nervous system abnormality | Tuba1aem1Rstot/Tuba1aem1Rstot | involves: C57BL/6J * C57BL/6N | J:278765 | View | ||||
| congenital nervous system abnormality | Tuba1aem1Rstot/Tuba1aquas | involves: C57BL/6J * C57BL/6N | J:278765 | View | ||||
| congenital nervous system abnormality | Tuba1aem2Rstot/Tuba1aem2Rstot | involves: C57BL/6J * C57BL/6N | J:278765 | View | ||||
| holoprosencephaly | NosipGt(OST138992)Lex/NosipGt(OST138992)Lex | B6.129S5-NosipGt(OST138992)Lex | J:245546 | View | ||||
| holoprosencephaly | Pgap1m1Nisw/Pgap1m1Nisw | involves: C57BL/6J | J:187360 | View | ||||
| holoprosencephaly | Pignm1Nisw/Pignm1Nisw | involves: 129S1/SvImJ * C3H/HeJ * C57BL/6J | J:187360 | View | ||||
| lissencephaly | Arxtm1Kki/Y | involves: 129P2/OlaHsd * C57BL | J:79871 | View | ||||
| lissencephaly | Arxtm2Kki/Y | involves: 129S/SvEv * C57BL/6J | J:197588 | View | ||||
| lissencephaly |
Dag1tm1Kcam/Dag1tm2Kcam Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129X1/SvJ * FVB/N | J:86901 | View | ||||
| lissencephaly |
Dag1tm2Kcam/Dag1tm2Kcam Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129X1/SvJ * FVB/N | J:86901 | View | ||||
| lissencephaly | Dcxtm1.2Ffr/Y | either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) | J:108229 | View | ||||
| microcephaly | Copb2em1Rstot/Copb2em2Rstot | involves: C57BL/6 * C57BL/6J * CD-1 * DBA/2 | J:252710 | View | ||||
| microcephaly | Kif20bmagoo/Kif20bmagoo | involves: BALB/c * C57BL/6 | J:242310 | View | ||||
| microcephaly | Ppil1em3Jgg/Ppil1em3Jgg | C57BL/6-Ppil1em3Jgg | J:300487 | View | ||||
| microcephaly | Ppil1em4Jgg/Ppil1em4Jgg | C57BL/6-Ppil1em4Jgg | J:300487 | View | ||||
| microcephaly |
Tubb5tm1.1Dak/Tubb5tm1.1Dak Tg(Nes-cre)1Kln/0 |
involves: 129P2/OlaHsd * C57BL/6 * SJL | J:240157 | View | ||||
| microcephaly |
Tubb5tm2.1Dak/Tubb5+ Tg(Nes-cre)1Kln/0 |
involves: 129P2/OlaHsd * C57BL/6 * SJL | J:240157 | View | ||||
| Additional Complex Models | holoprosencephaly |
Chrdtm1Emdr/Chrdtm1Emdr Nodaltm1Rob/Nodal+ |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ | J:161524 | View | |||
| holoprosencephaly |
Nogtm1Amc/Nogtm1Amc Smad3tm1Xfw/Smad3+ |
involves: 129/Sv * 129S1/Sv | J:161524 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | anencephaly | Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc | FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc | J:96325 | View | |||
| holoprosencephaly 4 | Tgif1tm1.1Caw/Tgif1tm1.1Caw | involves: C57BL/6 * FVB/N | J:97642 | View | ||||