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All mouse models of high grade glioma with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
 | glioblastoma |
Nf1tm1Fcr/Nf1tm1Fcr Trp53tm1Elee/Trp53tm1Elee Tg(GFAP-cre)25Mes/0 |
involves: 129S/SvEv * 129S4/SvJae * FVB/N | J:149662 | View | |||
| glioblastoma |
Trp53tm1Elee/Trp53tm1Tyj Tg(GFAP-cre)25Mes/0 |
involves: 129S2/SvPas * 129S4/SvJae * FVB/N | J:149662 | View | ||||
| high grade glioma | Tg(GFAP-Hras1)2Agu/Tg(GFAP-Hras1)2Agu | involves: 129S1/Sv * 129X1/SvJ * ICR | J:69129 | View | ||||
| malignant astrocytoma | Tg(GFAP-Hras1)2Agu/Tg(GFAP-Hras1)2Agu | involves: 129S1/Sv * 129X1/SvJ * ICR | J:69129 | View | ||||
 | high grade glioma |
Cdkn2atm1Rdp/Cdkn2atm1Rdp Col1a1tm1(CAG-EGFR)Char/Col1a1tm1(CAG-EGFR)Char Ptentm1Hwu/Ptentm1Hwu |
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL | J:146494 | View | |||
| high grade glioma |
Cdkn2atm1Rdp/Cdkn2atm1Rdp Col1a1tm1(CAG-EGFR)Char/Col1a1tm2(CAG-EGFR*)Char Ptentm1Hwu/Ptentm1Hwu |
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL | J:146494 | View | ||||
| high grade glioma |
Cdkn2atm1Rdp/Cdkn2atm1Rdp Col1a1tm2(CAG-EGFR*)Char/Col1a1tm2(CAG-EGFR*)Char Ptentm1Hwu/Ptentm1Hwu |
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL | J:146494 | View | ||||
| high grade glioma |
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor Ptentm1Mro/Ptentm1Mro Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+ Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor | J:229481 | View | ||||
| high grade glioma |
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor Ptentm1Mro/Ptentm1Mro Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S4/SvJaeSor | J:229481 | View | ||||
| high grade glioma |
Tg(S100b-v-erbB)4496Waw/0 Trp53tm1Brd/Trp53tm1Brd |
involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J | J:137800 | View | ||||
| Transgenes and Other Mutations | malignant astrocytoma |
Ptentm2.1Ppp/Ptentm2.1Ppp Tg(GFAP-TAg121)1Tvd/0 |
involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N | J:99385 | View | |||
| malignant astrocytoma | Tg(GFAP-SRC)1Aag/0 | involves: C3H * C57BL/6 | J:40335 | View | ||||
| malignant astrocytoma | Tg(GFAP-SRC)2Aag/0 | involves: C3H * C57BL/6 | J:40335 | View | ||||
| malignant astrocytoma | Tg(GFAP-TAg121)1Tvd/0 | involves: C57BL/6 * DBA/2 * FVB/N | J:77132 | View | ||||
| oligodendroglioma |
Cdkn2atm1Rdp/Cdkn2a+ Tg(S100b-v-erbB)4496Waw/0 |
involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL | J:82649 | View | ||||
| oligodendroglioma |
Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw/0 |
involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL | J:82649 | View | ||||
| oligodendroglioma | Tg(S100b-v-erbB)4496Waw/0 | involves: C57BL/6J * DBA/2J * FVB/N | J:82649 | View | ||||
| oligodendroglioma |
Tg(S100b-v-erbB)4496Waw/0 Trp53tm1Brd/Trp53+ |
involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N | J:82649 | View | ||||
| Additional Complex Models | glioblastoma proneural subtype |
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu Trp53tm1Thl/Trp53tm1Thl Tyrc-Brd/Tyrc-Brd |
involves: 129/Sv * 129S4/SvJae * C57BL/6 | J:172585 | View | |||
| glioblastoma proneural subtype |
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu Tyrc-Brd/Tyrc-Brd |
involves: 129/Sv * 129S4/SvJae * C57BL/6 | J:172585 | View | ||||
| malignant astrocytoma |
Nf1tm1Par/Nf1+ Ptentm1Hwu/Pten+ Trp53tm1Tyj/Trp53+ Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N | J:134611 | View | ||||
| malignant astrocytoma |
Nf1tm1Par/Nf1+ Trp53tm1Elee/Trp53+ Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N | J:134611 | View | ||||
| malignant astrocytoma |
Nf1tm1Par/Nf1+ Trp53tm1Tyj/Trp53+ Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N | J:134611 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
(C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
(CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
(CBA/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
(SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ + | J:64364 | View | ||||
| oligodendroglioma |
Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(NES-TVA)J12Ech/0 |
involves: 129/Sv * C57BL/6 * FVB/N * SJL | J:153220 | View | ||||