Excel File Text File All mouse models of hepatobiliary disease with phenotypic similarity to the human disease
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
      Alagille syndrome Jag1Mhdahtu/Jag1+ C3HeB/FeJ-Jag1Mhdahtu J:72108 View
Alagille syndrome Jag1Ndr/Jag1Ndr involves: C3HeB/FeJ * C57BL/6 J:277897 View
Alagille syndrome Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia J:189213 View
Alagille syndrome Jag1tm1Frad/Jag1tm1Frad
Tg(Tagln-cre)1Her/0
B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her J:166890 View
Alagille syndrome Jag1tm1Grid/Jag1+
Notch2tm1Grid/Notch2+
involves: 129S1/Sv * C57BL/6J J:74574 View
Alagille syndrome Jag1tm2Grid/Jag1tm2Grid
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * C57BL/6 * CBA J:181120 View
cholestasis Abcb4tm1Bor/Abcb4tm1Bor C.129P2-Abcb4tm1Bor J:199949 View
hepatocellular carcinoma Apctm2.1Cip/Apctm2.1Cip involves: 129P2/OlaHsd * C57BL/6N J:94721 View
hepatocellular carcinoma Nr1h4tm1Gonz/Nr1h4tm1Gonz involves: 129X1/SvJ * C57BL/6 J:118204, J:170790 View
hepatocellular carcinoma Nr1h4tm1Gonz/Nr1h4tm1Gonz involves: 129X1/SvJ * C57BL/6N J:121075, J:170790 View
intrahepatic cholangiocarcinoma Krastm4Tyj/Kras+
Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA J:254370 View
intrahepatic cholangiocarcinoma Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * DBA J:184949 View
intrahepatic cholangiocarcinoma Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA J:184949 View
intrahepatic cholangiocarcinoma Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA J:184949 View
intrahepatic cholestasis Abcb4tm1Bor/Abcb4tm1Bor involves: 129P2/OlaHsd * FVB/N J:175015 View
intrahepatic cholestasis Abcb4tm1Bor/Abcb4tm1Bor
Portm1Wolf/Portm1Wolf
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N J:215915 View
metabolic dysfunction-associated steatotic liver disease Leprdb/Leprdb B6.BKS(D)-Leprdb/JOrlRj J:277927 View
metabolic dysfunction-associated steatotic liver disease Pnpla3tm2.1Hobb/Pnpla3tm2.1Hobb involves: 129 * C57BL/6J J:264475 View
      biliary atresia Sox17tm1Ysk/Sox17+ B6.129S1-Sox17tm1Ysk J:194071, J:241569 View
Caroli syndrome Pkhd1cyli/Pkhd1cyli D2.Cg-(D4Mit42-D4Smh6b) Pkhd1cyli/EiJ J:343537 View
cholecystitis Abcb4tm1Bor/Abcb4tm1Bor FVB.129P2-Abcb4tm1Bor/J J:105357 View
hepatitis Tg(APCS-Ifng)5Imeg/0 involves: C57BL/6 * DBA/2 J:16979 View
hepatocellular adenoma Ptpn11tm1Gsf/Ptpn11tm1Gsf
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA J:172422 View
hepatocellular carcinoma Abcb4tm1Bor/Abcb4tm1Bor either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB/N) J:21232 View
hepatocellular carcinoma Cdkn1atm1(HBsAg)Xya/Cdkn1a+ either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) J:88078 View
hepatocellular carcinoma Cdkn1atm1(HBsAg)Xya/Cdkn1atm1(HBsAg)Xya either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) J:88078 View
hepatocellular carcinoma Cdkn1atm2(HBx)Xya/Cdkn1a+ either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) J:88078 View
hepatocellular carcinoma Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) J:88078 View
hepatocellular carcinoma Foxm1tm1Rhc/Foxm1tm1Rhc involves: 129X1/SvJ J:89472 View
hepatocellular carcinoma Gnmttm1Ymac/Gnmttm1Ymac involves: 129 * C57BL/6 J:146081 View
hepatocellular carcinoma Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Tg(Alb-E2F1)8Sst/0
involves: C57BL/6 * CBA J:101128, J:170790 View
hepatocellular carcinoma Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Tg(MtTGFA)42Lmb/0
involves: C57BL/6 * CBA * CD-1 J:34434 View
hepatocellular carcinoma Iqgap2tm1Vs/Iqgap2tm1Vs involves: 129S4/SvJae J:205882 View
hepatocellular carcinoma Krt18tm1Tmm/Krt18tm1Tmm involves: 129P2/OlaHsd J:309021 View
hepatocellular carcinoma Lect2tm1Ymg/Lect2tm1Ymg
Tg(Pklr-Myc)73Ak/0
B6.Cg-Lect2tm1Ymg Tg(Pklr-Myc)73Ak J:184496 View
hepatocellular carcinoma Mcm9Gt(AW0655)Wtsi/Mcm9Gt(AW0655)Wtsi involves: 129P2/OlaHsd * C3HeB/FeJ J:177420 View
hepatocellular carcinoma Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg involves: 129P2/OlaHsd * C3HeB/FeJ J:177420 View
hepatocellular carcinoma Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg involves: 129P2/OlaHsd * C3HeB/FeJ J:177420 View
hepatocellular carcinoma Nfe2l1tm1Jefc/Nfe2l1tm1Ywk
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129X1/SvJ * C57BL/6J J:97188 View
hepatocellular carcinoma Ptentm1Hwu/Ptentm1Hwu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * DBA J:218587 View
hepatocellular carcinoma Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA J:90905 View
hepatocellular carcinoma Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA J:138099 View
hepatocellular carcinoma Sav1tm2.1Dlim/Sav1tm2.1Dlim
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * DBA J:238319 View
hepatocellular carcinoma Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Tg(Pklr-Myc)73Ak/0
B6.Cg-Tcra-Jtm1Tgi Tg(Pklr-Myc)73Ak J:184496 View
hepatocellular carcinoma Tg(Alb1-Myc)#Sst/0
Tg(MtTGFA)Lmb/0
involves: C57BL/6 * CBA * CD-1 J:176432 View
hepatocellular carcinoma Tg(HBVX*,-Myc)#Skp/Tg(HBVX*,-Myc)#Skp Not Specified J:81098, J:202732 View
hepatocellular carcinoma Tg(Mup3-Plau)350-2Eps/? C57BL/6-Tg(Mup3-Plau)350-2Eps J:233146 View
hepatocellular carcinoma Tg(Pklr-Myc)73Ak/0 B6.Cg-Tg(Pklr-Myc)73Ak J:184496 View
hepatocellular carcinoma Tg(Pklr-Myc)73Ak/0 involves: C57BL/6 * DBA J:185488 View
hepatocellular carcinoma TxnipHyplip1/Txnip+ involves: CAST/Ei * HcB19/Dem J:112292 View
hepatocellular carcinoma TxnipHyplip1/TxnipHyplip1 HcB19/Dem-TxnipHyplip1 J:112292 View
hepatocellular carcinoma TxnipHyplip1/TxnipHyplip1 involves: CAST/Ei * HcB19/Dem J:112292 View
hepatocellular carcinoma Uacatm1Kiy/Uacatm1Kiy B6.129P2-Uacatm1Kiy J:157049 View
liver disease Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Trmutm1Tomik/Trmutm1Tomik
involves: C57BL/6 * DBA J:235644 View
liver disease Ssu72tm1Cwl/Ssu72tm1Cwl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
B6.Cg-Ssu72tm1Cwl Speer6-ps1Tg(Alb-cre)21Mgn J:309624 View
metabolic dysfunction-associated steatohepatitis Krt18tm1Tmm/Krt18tm1Tmm involves: 129P2/OlaHsd J:309021 View
metabolic dysfunction-associated steatohepatitis Mc4rtm1Matsu/Mc4rtm1Matsu C57BL/6J-Mc4rtm1Matsu J:285412 View
metabolic dysfunction-associated steatotic liver disease Aldh1l2tm2e(KOMP)Wtsi/Aldh1l2tm2e(KOMP)Wtsi involves: C57BL/6 * C57BL/6N J:299012 View
metabolic dysfunction-associated steatotic liver disease Iigp1cem1Btlr/Iigp1cem1Btlr C57BL/6J-Iigp1cem1Btlr J:333470 View
metabolic dysfunction-associated steatotic liver disease Iigp1cM1Btlr/Iigp1cM1Btlr C57BL/6J-Iigp1cM1Btlr J:333470 View
metabolic dysfunction-associated steatotic liver disease Iigp1cM2Btlr/Iigp1cM2Btlr C57BL/6J-Iigp1cM2Btlr J:333470 View
metabolic dysfunction-associated steatotic liver disease Lepob/Lepob B6.Cg-Lepob/JRj J:277927 View
metabolic dysfunction-associated steatotic liver disease Nlrp3tm1Bhk/Nlrp3tm1Bhk B6.129S6-Nlrp3tm1Bhk/J J:256504 View
metabolic dysfunction-associated steatotic liver disease Pgrmc1em1Ejho/Pgrmc1em1Ejho involves: C57BL/6N J:268130 View
metabolic dysfunction-associated steatotic liver disease Ppdpftm1Nju/Ppdpftm1Nju
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * DBA J:307283 View
metabolic dysfunction-associated steatotic liver disease Sidt2tm1.1Hzha/Sidt2tm1.1Hzha involves: 129S6/SvEvTac * C57BL/6J J:236042 View
polycystic liver disease Prkcshtm1Som/Prkcshtm1Som
Tg(CAG-cre/Esr1*)1Lbe/0
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 J:188763 View
polycystic liver disease Ucp2tm1Lowl/Ucp2tm1Lowl B6.129S4-Ucp2tm1Lowl J:272325 View
primary biliary cholangitis Map3k14aly/Map3k14aly involves: C57BL/6J J:48224 View
primary biliary cholangitis Zc3h12atm1c(EUCOMM)Hmgu/Zc3h12atm1c(EUCOMM)Hmgu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * C57BL/6N * DBA J:304105 View
primary sclerosing cholangitis Abcb4tm1Bor/Abcb4tm1Bor CAnNCrl.12P2(FVB)-Abcb4tm1Bor J:217802 View
primary sclerosing cholangitis Abcb4tm1Bor/Abcb4tm1Bor involves: 129P2/OlaHsd * BALB/c J:168123 View
steatotic liver disease Adktm1Bois/Adktm1Bois involves: 129P3/JEmsJ * C57BL/6 J:81518 View
steatotic liver disease Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Tg(Alb1-cre)7Gsc/0
involves: C57BL/6 * FVB/N J:118336 View
steatotic liver disease Ldlrtm1Her/Ldlrtm1Her involves: 129S7/SvEvBrd * C57BL/6 J:175559 View
steatotic liver disease Lepob/Lepob B6.Cg-Lepob/JRj J:220381 View
steatotic liver disease Lgals3tm1Ftl/Lgals3tm1Ftl involves: 129S2/SvPas * CD-1 J:116073, J:221030 View
steatotic liver disease Lrp6tm1Arma/Lrp6tm1Arma C57BL/6-Lrp6tm1Arma J:225450 View
steatotic liver disease Mc4rtm1Lowl/Mc4rtm1Lowl involves: 129S4/SvJae * C57BL/6J J:177386 View
steatotic liver disease Ptentm1Hwu/Ptentm1Hwu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * DBA J:216841 View
steatotic liver disease Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA J:90905 View
steatotic liver disease Sirt1tm1.2Cxd/Sirt1tm1.2Cxd
Tg(Alb1-cre)1Dlr/?
involves: 129S6/SvEvTac * FVB/N J:179193 View
steatotic liver disease Tg(Mup3-Plau)350-2Eps/? C57BL/6-Tg(Mup3-Plau)350-2Eps J:233146 View
      intrahepatic cholestasis Atp8b1tm1Nbf/Atp8b1tm1Nbf
Portm1Wolf/Portm1Wolf
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA J:215915 View
progressive familial intrahepatic cholestasis 4 Tjp1tm1.1Whun/Tjp1tm1.1Whun
Tjp2tm2Whun/Tjp2tm2Whun
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * C57BL/6NTac * DBA/2 J:306936 View
Transgenes and
Other Mutations
     hepatitis Tg(KRT18*R89C)22Rgo/0 involves: FVB/N J:241700 View
hepatitis Tg(KRT18*R89C)30Rgo/0 involves: FVB/N J:241700 View
hepatitis Tg(KRT18*R89C)50Rgo/0 involves: FVB/N J:241700 View
hepatocellular carcinoma Rb1tm3Tyj/Rb1tm3Tyj
Tg(tetO-MYC)36aBop/0
Tg(Cebpb-tTA)5Bjd/0
involves: FVB/N * NMRI J:172430 View
hepatocellular carcinoma Tg(Alb1HBV)44Bri/0 C57BL/6J-Tg(Alb1HBV)44Bri/J J:223921 View
hepatocellular carcinoma Tg(Alb-E2F1)8Sst/0 involves: C57BL/6J * CBA/J J:65354, J:101128, J:170790 View
hepatocellular carcinoma Tg(Alb-HBx)A112Tfts/0 involves: C57BL/6 J:104728 View
hepatocellular carcinoma Tg(Alb-HRAS*G12V)28Yu/0 involves: C57BL/6J * CBA/J J:107083, J:238319 View
hepatocellular carcinoma Tg(Alb-PDGFC)#Jcam/0 involves: C57BL/6 J:211984 View
hepatocellular carcinoma Tg(Alb-SND1)3aDsar/0 involves: C57BL/6 * CBA J:242582 View
hepatocellular carcinoma Tg(Alb-TAg)1Gjh/0 C3.Cg-Tg(Alb-TAg)1Gjh J:105110 View
hepatocellular carcinoma Tg(Alb-TAg)#Arnd/0 C3Fe.Cg-Tg(Alb-TAg)#Arnd J:171880 View
hepatocellular carcinoma Tg(Cebpb-tTA)5Bjd/0
Tg(tetO-MYC,-OVAL)#Gtgm/0
B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm J:186226 View
hepatocellular carcinoma Tg(HBV-HCV)Kko/0 C57BL/6N-Tg(HBV-HCV)Kko J:69727 View
hepatocellular carcinoma Tg(HBx)3Yu/0 involves: C57BL/6 * DBA J:56196 View
hepatocellular carcinoma Tg(Myl2-FGF19)1Dfre/? involves: FVB J:77160, J:187236 View
hepatocellular carcinoma Tg(SERPINA1-TAg)1812Jtsb/0 involves: C3H * C57BL/6 * ICR J:101633 View
hepatocellular carcinoma Tg(SERPINC1-SV40)A1Pbr/0 involves: C57BL/6 * DBA/2 J:101541 View
hepatocellular carcinoma Tg(SERPINC1-SV40)A1Pbr/Tg(SERPINC1-SV40)A1Pbr involves: C57BL/6 * DBA/2 J:101541 View
hepatocellular carcinoma Tg(tetO-MET)23Rwng/0
Tg(Cebpb-tTA)5Bjd/0
involves: FVB/N * NMRI J:69731 View
hepatocellular carcinoma Tg(tetO-MYC)36aBop/0
Tg(Cebpb-tTA)5Bjd/0
involves: FVB/N * NMRI J:93899, J:186226, J:172430 View
hepatocellular carcinoma X/Tg(SERPINC1-SV40)BPbr involves: C57BL/6 * DBA/2 J:101541, J:84204 View
metabolic dysfunction-associated steatotic liver disease Tg(Alb-SREBF1_ic)#Jkot/0 involves: C57BL/6 J:249664 View
metabolic dysfunction-associated steatotic liver disease Tg(aP2-SREBF1c)9884Reh/0 involves: C57BL/6J * SJL J:249664 View
steatotic liver disease Tg(Alb-PDGFC)#Jcam/0 involves: C57BL/6 J:96979 View
Additional
Complex
Models
     hepatocellular carcinoma Col1a1tm1(tetO-URI1)Ndj/Col1a1+
Tg(Cebpb-tTA)#Bjd/0
B6.Cg-Col1a1tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd J:217463 View
hepatocellular carcinoma Col1a1tm1(tetO-URI1)Ndj/Col1a1tm1(tetO-URI1)Ndj
Tg(Cebpb-tTA)#Bjd/0
B6.Cg-Col1a1tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd J:217463 View
hepatocellular carcinoma Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 J:177573 View
hepatocellular carcinoma Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA J:238319 View
hepatocellular carcinoma Tg(IRS1)1Mhep/0
Tg(SERPINA1-HBVX)1655Jtsb/0
involves: C3H * C57BL/6 * FVB * ICR J:227278 View


       
No similarity to the expected human disease phenotype was found.
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
NOT Models      Alagille syndrome Jag1tm1Grid/Jag1+ involves: 129S1/Sv * C57BL/6 * FVB J:54907 View
intrahepatic cholestasis Atp8b1tm1Nbf/Atp8b1tm1Nbf involves: 129S1/SvImJ * 129S4/SvJae J:89817 View