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All mouse models of Noonan syndrome with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | Noonan syndrome 1 |
Emx1tm1(cre)Krj/Emx1+ Ptpn11tm6Bgn/Ptpn11+ |
B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj | J:242312 | View | |||
| Noonan syndrome 1 | Ptpn11tm1Bgn/Ptpn11+ | involves: 129S4/SvJae * C57BL/6J | J:91609 | View | ||||
| Noonan syndrome 1 | Tg(Myh7-Ptpn11*Q79R)11Rbns/0 | FVB.Cg-Tg(Myh7-Ptpn11*Q79R)11Rbns | J:123963 | View | ||||
| Noonan syndrome 3 | Krastm4.1Bbd/Krastm4.1Bbd | involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N | J:223433 | View | ||||
| Noonan syndrome 4 | Sos1tm1.2Rak/Sos1+ | involves: 129S/Sv * C57BL/6 * FVB/N * SJL | J:171873 | View | ||||
| Noonan syndrome 4 | Sos1tm1.2Rak/Sos1tm1.2Rak | involves: 129S/Sv * C57BL/6 * FVB/N * SJL | J:171873 | View | ||||
| Noonan syndrome 5 | Raf1tm1.1Bgn/Raf1+ | involves: 129S6/SvEvTac * C57BL/6NCr | J:172034 | View | ||||
| Noonan syndrome 5 | Raf1tm2.1Ara/Raf1tm2.1Ara | involves: 129S6/SvEvTac * C57BL/6NCr | J:189143 | View | ||||
| Noonan syndrome 8 | Rit1tm1.1Tumg/Rit1+ | B6.Cg-Rit1tm1.1Tumg | J:277548 | View | ||||
| Noonan syndrome 10 | Lztr1tm1a(EUCOMM)Wtsi/Lztr1+ | involves: C57BL/6N | J:268690 | View | ||||
| | Noonan syndrome | Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr | involves: 129S1/Sv * 129X1/SvJ * NMRI | J:49840 | View | |||
| Noonan syndrome | Kat6bGt(pKC199)1Pgr/Kat6bGt(pKC199)1Pgr | involves: 129S2/SvPas | J:178264 | View | ||||
| Transgenes and Other Mutations | Noonan syndrome 1 |
H2az2Tg(Wnt1-cre)11Rth/H2az2+ Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 |
involves: C57BL/6J * CBA/J * FVB/N | J:153094 | View | |||
| Noonan syndrome 1 |
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0 |
involves: C3H * C57BL/6 * FVB/N | J:142212 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | Noonan syndrome 1 | Ptpn11tm1Paw/Ptpn11tm1Paw | involves: 129S1/Sv * 129X1/SvJ * CD-1 | J:43740 | View | |||
| Noonan syndrome 1 | Ptpn11tm1Rbn/Ptpn11+ | involves: 129 * Black Swiss | J:35137 | View | ||||
| Noonan syndrome 1 | Ptpn11tm1Rbn/Ptpn11tm1Rbn | involves: 129 * Black Swiss | J:35137 | View | ||||