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All mouse models of liver disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | Alagille syndrome | Jag1Mhdahtu/Jag1+ | C3HeB/FeJ-Jag1Mhdahtu | J:72108 | View | |||
| Alagille syndrome | Jag1Ndr/Jag1Ndr | involves: C3HeB/FeJ * C57BL/6 | J:277897 | View | ||||
| Alagille syndrome |
Jag1tm1Frad/Jag1tm1Frad Tg(Cdh5-cre)7Mlia/0 |
B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia | J:189213 | View | ||||
| Alagille syndrome |
Jag1tm1Frad/Jag1tm1Frad Tg(Tagln-cre)1Her/0 |
B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her | J:166890 | View | ||||
| Alagille syndrome |
Jag1tm1Grid/Jag1+ Notch2tm1Grid/Notch2+ |
involves: 129S1/Sv * C57BL/6J | J:74574 | View | ||||
| Alagille syndrome |
Jag1tm2Grid/Jag1tm2Grid H2az2Tg(Wnt1-cre)11Rth/H2az2+ |
involves: 129S1/Sv * C57BL/6 * CBA | J:181120 | View | ||||
| hepatocellular carcinoma | Apctm2.1Cip/Apctm2.1Cip | involves: 129P2/OlaHsd * C57BL/6N | J:94721 | View | ||||
| hepatocellular carcinoma | Nr1h4tm1Gonz/Nr1h4tm1Gonz | involves: 129X1/SvJ * C57BL/6 | J:118204, J:170790 | View | ||||
| hepatocellular carcinoma | Nr1h4tm1Gonz/Nr1h4tm1Gonz | involves: 129X1/SvJ * C57BL/6N | J:121075, J:170790 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Leprdb/Leprdb | B6.BKS(D)-Leprdb/JOrlRj | J:277927 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Pnpla3tm2.1Hobb/Pnpla3tm2.1Hobb | involves: 129 * C57BL/6J | J:264475 | View | ||||
| polycystic liver disease |
Prkcshtm1Som/Prkcshtm1Som Tg(CAG-cre/Esr1*)1Lbe/0 |
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 | J:188763 | View | ||||
| | Caroli syndrome | Pkhd1cyli/Pkhd1cyli | D2.Cg-(D4Mit42-D4Smh6b) Pkhd1cyli/EiJ | J:343537 | View | |||
| hepatitis | Tg(APCS-Ifng)5Imeg/0 | involves: C57BL/6 * DBA/2 | J:16979 | View | ||||
| hepatocellular adenoma |
Ptpn11tm1Gsf/Ptpn11tm1Gsf Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA | J:172422 | View | ||||
| hepatocellular carcinoma | Abcb4tm1Bor/Abcb4tm1Bor | either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB/N) | J:21232 | View | ||||
| hepatocellular carcinoma | Cdkn1atm1(HBsAg)Xya/Cdkn1a+ | either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) | J:88078 | View | ||||
| hepatocellular carcinoma | Cdkn1atm1(HBsAg)Xya/Cdkn1atm1(HBsAg)Xya | either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) | J:88078 | View | ||||
| hepatocellular carcinoma | Cdkn1atm2(HBx)Xya/Cdkn1a+ | either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) | J:88078 | View | ||||
| hepatocellular carcinoma | Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya | either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) | J:88078 | View | ||||
| hepatocellular carcinoma | Foxm1tm1Rhc/Foxm1tm1Rhc | involves: 129X1/SvJ | J:89472 | View | ||||
| hepatocellular carcinoma | Gnmttm1Ymac/Gnmttm1Ymac | involves: 129 * C57BL/6 | J:146081 | View | ||||
| hepatocellular carcinoma |
Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+ Tg(Alb-E2F1)8Sst/0 |
involves: C57BL/6 * CBA | J:101128, J:170790 | View | ||||
| hepatocellular carcinoma |
Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+ Tg(MtTGFA)42Lmb/0 |
involves: C57BL/6 * CBA * CD-1 | J:34434 | View | ||||
| hepatocellular carcinoma | Iqgap2tm1Vs/Iqgap2tm1Vs | involves: 129S4/SvJae | J:205882 | View | ||||
| hepatocellular carcinoma | Krt18tm1Tmm/Krt18tm1Tmm | involves: 129P2/OlaHsd | J:309021 | View | ||||
| hepatocellular carcinoma |
Lect2tm1Ymg/Lect2tm1Ymg Tg(Pklr-Myc)73Ak/0 |
B6.Cg-Lect2tm1Ymg Tg(Pklr-Myc)73Ak | J:184496 | View | ||||
| hepatocellular carcinoma | Mcm9Gt(AW0655)Wtsi/Mcm9Gt(AW0655)Wtsi | involves: 129P2/OlaHsd * C3HeB/FeJ | J:177420 | View | ||||
| hepatocellular carcinoma | Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg | involves: 129P2/OlaHsd * C3HeB/FeJ | J:177420 | View | ||||
| hepatocellular carcinoma | Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg | involves: 129P2/OlaHsd * C3HeB/FeJ | J:177420 | View | ||||
| hepatocellular carcinoma |
Nfe2l1tm1Jefc/Nfe2l1tm1Ywk Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129X1/SvJ * C57BL/6J | J:97188 | View | ||||
| hepatocellular carcinoma |
Ptentm1Hwu/Ptentm1Hwu Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129S4/SvJae * C57BL/6 * DBA | J:218587 | View | ||||
| hepatocellular carcinoma |
Ptentm2Mak/Ptentm2Mak Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA | J:90905 | View | ||||
| hepatocellular carcinoma |
Ptentm2Mak/Ptentm2Mak Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129P2/OlaHsd * C57BL/6 * DBA | J:138099 | View | ||||
| hepatocellular carcinoma |
Sav1tm2.1Dlim/Sav1tm2.1Dlim Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: C57BL/6 * DBA | J:238319 | View | ||||
| hepatocellular carcinoma |
Tcra-Jtm1Tgi/Tcra-Jtm1Tgi Tg(Pklr-Myc)73Ak/0 |
B6.Cg-Tcra-Jtm1Tgi Tg(Pklr-Myc)73Ak | J:184496 | View | ||||
| hepatocellular carcinoma |
Tg(Alb1-Myc)#Sst/0 Tg(MtTGFA)Lmb/0 |
involves: C57BL/6 * CBA * CD-1 | J:176432 | View | ||||
| hepatocellular carcinoma | Tg(HBVX*,-Myc)#Skp/Tg(HBVX*,-Myc)#Skp | Not Specified | J:81098, J:202732 | View | ||||
| hepatocellular carcinoma | Tg(Mup3-Plau)350-2Eps/? | C57BL/6-Tg(Mup3-Plau)350-2Eps | J:233146 | View | ||||
| hepatocellular carcinoma | Tg(Pklr-Myc)73Ak/0 | B6.Cg-Tg(Pklr-Myc)73Ak | J:184496 | View | ||||
| hepatocellular carcinoma | Tg(Pklr-Myc)73Ak/0 | involves: C57BL/6 * DBA | J:185488 | View | ||||
| hepatocellular carcinoma | TxnipHyplip1/Txnip+ | involves: CAST/Ei * HcB19/Dem | J:112292 | View | ||||
| hepatocellular carcinoma | TxnipHyplip1/TxnipHyplip1 | HcB19/Dem-TxnipHyplip1 | J:112292 | View | ||||
| hepatocellular carcinoma | TxnipHyplip1/TxnipHyplip1 | involves: CAST/Ei * HcB19/Dem | J:112292 | View | ||||
| hepatocellular carcinoma | Uacatm1Kiy/Uacatm1Kiy | B6.129P2-Uacatm1Kiy | J:157049 | View | ||||
| liver disease |
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Trmutm1Tomik/Trmutm1Tomik |
involves: C57BL/6 * DBA | J:235644 | View | ||||
| liver disease |
Ssu72tm1Cwl/Ssu72tm1Cwl Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
B6.Cg-Ssu72tm1Cwl Speer6-ps1Tg(Alb-cre)21Mgn | J:309624 | View | ||||
| metabolic dysfunction-associated steatohepatitis | Krt18tm1Tmm/Krt18tm1Tmm | involves: 129P2/OlaHsd | J:309021 | View | ||||
| metabolic dysfunction-associated steatohepatitis | Mc4rtm1Matsu/Mc4rtm1Matsu | C57BL/6J-Mc4rtm1Matsu | J:285412 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Aldh1l2tm2e(KOMP)Wtsi/Aldh1l2tm2e(KOMP)Wtsi | involves: C57BL/6 * C57BL/6N | J:299012 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Iigp1cem1Btlr/Iigp1cem1Btlr | C57BL/6J-Iigp1cem1Btlr | J:333470 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Iigp1cM1Btlr/Iigp1cM1Btlr | C57BL/6J-Iigp1cM1Btlr | J:333470 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Iigp1cM2Btlr/Iigp1cM2Btlr | C57BL/6J-Iigp1cM2Btlr | J:333470 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Lepob/Lepob | B6.Cg-Lepob/JRj | J:277927 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Nlrp3tm1Bhk/Nlrp3tm1Bhk | B6.129S6-Nlrp3tm1Bhk/J | J:256504 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Pgrmc1em1Ejho/Pgrmc1em1Ejho | involves: C57BL/6N | J:268130 | View | ||||
| metabolic dysfunction-associated steatotic liver disease |
Ppdpftm1Nju/Ppdpftm1Nju Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: C57BL/6 * DBA | J:307283 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Sidt2tm1.1Hzha/Sidt2tm1.1Hzha | involves: 129S6/SvEvTac * C57BL/6J | J:236042 | View | ||||
| polycystic liver disease | Ucp2tm1Lowl/Ucp2tm1Lowl | B6.129S4-Ucp2tm1Lowl | J:272325 | View | ||||
| primary biliary cholangitis | Map3k14aly/Map3k14aly | involves: C57BL/6J | J:48224 | View | ||||
| primary biliary cholangitis |
Zc3h12atm1c(EUCOMM)Hmgu/Zc3h12atm1c(EUCOMM)Hmgu Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: C57BL/6 * C57BL/6N * DBA | J:304105 | View | ||||
| steatotic liver disease | Adktm1Bois/Adktm1Bois | involves: 129P3/JEmsJ * C57BL/6 | J:81518 | View | ||||
| steatotic liver disease |
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa Tg(Alb1-cre)7Gsc/0 |
involves: C57BL/6 * FVB/N | J:118336 | View | ||||
| steatotic liver disease | Ldlrtm1Her/Ldlrtm1Her | involves: 129S7/SvEvBrd * C57BL/6 | J:175559 | View | ||||
| steatotic liver disease | Lepob/Lepob | B6.Cg-Lepob/JRj | J:220381 | View | ||||
| steatotic liver disease | Lgals3tm1Ftl/Lgals3tm1Ftl | involves: 129S2/SvPas * CD-1 | J:116073, J:221030 | View | ||||
| steatotic liver disease | Lrp6tm1Arma/Lrp6tm1Arma | C57BL/6-Lrp6tm1Arma | J:225450 | View | ||||
| steatotic liver disease | Mc4rtm1Lowl/Mc4rtm1Lowl | involves: 129S4/SvJae * C57BL/6J | J:177386 | View | ||||
| steatotic liver disease |
Ptentm1Hwu/Ptentm1Hwu Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129S4/SvJae * C57BL/6 * DBA | J:216841 | View | ||||
| steatotic liver disease |
Ptentm2Mak/Ptentm2Mak Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA | J:90905 | View | ||||
| steatotic liver disease |
Sirt1tm1.2Cxd/Sirt1tm1.2Cxd Tg(Alb1-cre)1Dlr/? |
involves: 129S6/SvEvTac * FVB/N | J:179193 | View | ||||
| steatotic liver disease | Tg(Mup3-Plau)350-2Eps/? | C57BL/6-Tg(Mup3-Plau)350-2Eps | J:233146 | View | ||||
| Transgenes and Other Mutations | hepatitis | Tg(KRT18*R89C)22Rgo/0 | involves: FVB/N | J:241700 | View | |||
| hepatitis | Tg(KRT18*R89C)30Rgo/0 | involves: FVB/N | J:241700 | View | ||||
| hepatitis | Tg(KRT18*R89C)50Rgo/0 | involves: FVB/N | J:241700 | View | ||||
| hepatocellular carcinoma |
Rb1tm3Tyj/Rb1tm3Tyj Tg(tetO-MYC)36aBop/0 Tg(Cebpb-tTA)5Bjd/0 |
involves: FVB/N * NMRI | J:172430 | View | ||||
| hepatocellular carcinoma | Tg(Alb1HBV)44Bri/0 | C57BL/6J-Tg(Alb1HBV)44Bri/J | J:223921 | View | ||||
| hepatocellular carcinoma | Tg(Alb-E2F1)8Sst/0 | involves: C57BL/6J * CBA/J | J:65354, J:101128, J:170790 | View | ||||
| hepatocellular carcinoma | Tg(Alb-HBx)A112Tfts/0 | involves: C57BL/6 | J:104728 | View | ||||
| hepatocellular carcinoma | Tg(Alb-HRAS*G12V)28Yu/0 | involves: C57BL/6J * CBA/J | J:107083, J:238319 | View | ||||
| hepatocellular carcinoma | Tg(Alb-PDGFC)#Jcam/0 | involves: C57BL/6 | J:211984 | View | ||||
| hepatocellular carcinoma | Tg(Alb-SND1)3aDsar/0 | involves: C57BL/6 * CBA | J:242582 | View | ||||
| hepatocellular carcinoma | Tg(Alb-TAg)1Gjh/0 | C3.Cg-Tg(Alb-TAg)1Gjh | J:105110 | View | ||||
| hepatocellular carcinoma | Tg(Alb-TAg)#Arnd/0 | C3Fe.Cg-Tg(Alb-TAg)#Arnd | J:171880 | View | ||||
| hepatocellular carcinoma |
Tg(Cebpb-tTA)5Bjd/0 Tg(tetO-MYC,-OVAL)#Gtgm/0 |
B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm | J:186226 | View | ||||
| hepatocellular carcinoma | Tg(HBV-HCV)Kko/0 | C57BL/6N-Tg(HBV-HCV)Kko | J:69727 | View | ||||
| hepatocellular carcinoma | Tg(HBx)3Yu/0 | involves: C57BL/6 * DBA | J:56196 | View | ||||
| hepatocellular carcinoma | Tg(Myl2-FGF19)1Dfre/? | involves: FVB | J:77160, J:187236 | View | ||||
| hepatocellular carcinoma | Tg(SERPINA1-TAg)1812Jtsb/0 | involves: C3H * C57BL/6 * ICR | J:101633 | View | ||||
| hepatocellular carcinoma | Tg(SERPINC1-SV40)A1Pbr/0 | involves: C57BL/6 * DBA/2 | J:101541 | View | ||||
| hepatocellular carcinoma | Tg(SERPINC1-SV40)A1Pbr/Tg(SERPINC1-SV40)A1Pbr | involves: C57BL/6 * DBA/2 | J:101541 | View | ||||
| hepatocellular carcinoma |
Tg(tetO-MET)23Rwng/0 Tg(Cebpb-tTA)5Bjd/0 |
involves: FVB/N * NMRI | J:69731 | View | ||||
| hepatocellular carcinoma |
Tg(tetO-MYC)36aBop/0 Tg(Cebpb-tTA)5Bjd/0 |
involves: FVB/N * NMRI | J:93899, J:186226, J:172430 | View | ||||
| hepatocellular carcinoma | X/Tg(SERPINC1-SV40)BPbr | involves: C57BL/6 * DBA/2 | J:101541, J:84204 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Tg(Alb-SREBF1_ic)#Jkot/0 | involves: C57BL/6 | J:249664 | View | ||||
| metabolic dysfunction-associated steatotic liver disease | Tg(aP2-SREBF1c)9884Reh/0 | involves: C57BL/6J * SJL | J:249664 | View | ||||
| steatotic liver disease | Tg(Alb-PDGFC)#Jcam/0 | involves: C57BL/6 | J:96979 | View | ||||
| Additional Complex Models | hepatocellular carcinoma |
Col1a1tm1(tetO-URI1)Ndj/Col1a1+ Tg(Cebpb-tTA)#Bjd/0 |
B6.Cg-Col1a1tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd | J:217463 | View | |||
| hepatocellular carcinoma |
Col1a1tm1(tetO-URI1)Ndj/Col1a1tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd/0 |
B6.Cg-Col1a1tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd | J:217463 | View | ||||
| hepatocellular carcinoma |
Rb1tm3Tyj/Rb1tm3Tyj Rbl1tm1Tyj/Rbl1tm1Tyj Rbl2tm2.1Tyj/Rbl2tm2.1Tyj |
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 | J:177573 | View | ||||
| hepatocellular carcinoma |
Stk3tm1Jav/Stk3tm1Jav Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ |
involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA | J:238319 | View | ||||
| hepatocellular carcinoma |
Tg(IRS1)1Mhep/0 Tg(SERPINA1-HBVX)1655Jtsb/0 |
involves: C3H * C57BL/6 * FVB * ICR | J:227278 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | Alagille syndrome | Jag1tm1Grid/Jag1+ | involves: 129S1/Sv * C57BL/6 * FVB | J:54907 | View | |||